Results 31 to 40 of about 292,234 (239)

I2B is a Small Cytosolic Protein that Participates in Vacuole Fusion [PDF]

, 1997
Saccharomyces cerevisiae vacuole inheritance requires two low molecular weight activities, LMA1 and LMA2. LMA1 is a heterodimer of thioredoxin and protease B inhibitor 2 (IB2).
Albert Haas,, Kimberly Seefeld,, Slusarewicz, Paul, Wickner, William T, Zuoyu Xu,   +4 more
core   +5 more sources

Realtime, continuous assessment of complex-mixture protease and protease inhibitor activity

4 open, 2022
Recently the treatment PAXLOVID™ (nirmatrelvir co-packaged with ritonavir) was authorized for use as a treatment for COVID-19. The presumed mechanism of action of the treatment, an inhibitor of a Sars-Cov-2 “3CL” protease, continues decades-long interest
Leonard Sarah-Ellen, Kenis Paul J.A., Perkins Ray C.   +2 more
doaj   +1 more source

Effect of diets containing a purified soybean trypsin inhibitor on growth performance, digestive proteases and intestinal histology in juvenile sea bream (Sparus aurata L.) [PDF]

, 2010
Juvenile sea bream were fed on diets containing 0.0, 2.0 or 4.0 g/kg of a soybean trypsin inhibitor (SBTI) for 30 days. The growth performance, total protease activity and intestinal histology were studied after 0,15 and 30 days of dietary treatment.
Alarcón, Alarcón, Alarcón, Anderson, Bonaldo, Bonaldo, Boonyaratpalin, Choi, Dabrowski, El-Sayed, Francis, Gallagher, García-Carreño, Gomes, Grant, Green, Grisdale-Helland, Haard, Johnson, Kaushik, Kissil, Knudsen, Krogdahl, Krogdahl, Krogdahl, Laemmli, Liddle, Lilleeng, Lim, Makkar, Moyano, NRC, National Research Council, Oliva-Teles, Olli, Olsen, Ostaszewska, Pelissero, Peres, Psochiou, Refstie, Refstie, Richardson, Robaina, Santigosa, Sanz, Sveier, Temler, Van Den Ingh, Venou, Venou, Wang   +50 more
core   +2 more sources

Evolutionary Multi-Objective Design of SARS-CoV-2 Protease Inhibitor Candidates

, 2020
Computational drug design based on artificial intelligence is an emerging research area. At the time of writing this paper, the world suffers from an outbreak of the coronavirus SARS-CoV-2.
A Alhossary, CA Lipinski, CA Nicolaou, D Douguet, D Weininger, E van der Horst, E Zitzler, GR Bickerton, H Nguyen, HG Beyer, K Deb, L Zhang, N Brown, N Brown, O Trott, P Ertl, P Ertl, RF de Freitas, RV Devi, SCH Pegg, SS Kaplan, T Gaillard, T Krause, TT Wager, W Dai   +24 more
core   +1 more source

Next generation sequencing of HIV-1 protease in the PIVOT trial of protease inhibitor monotherapy [PDF]

, 2018
BACKGROUND: The PIVOT trial examined whether patients with suppressed viral load on combination antiretroviral therapy could be safely switched long-term to ritonavir-boosted protease inhibitor (PI) monotherapy.
Arenas-Pinto, A, Dunn, DT, Mbisa, JL, or the Protease Inhibitor Monotherapy Versus Ongoing Triple Ther, ., Paton, NI, Stöhr, W, Tostevin, A   +6 more
core   +1 more source

Role of Protease-Inhibitors in Ocular Diseases

Molecules, 2014
It has been demonstrated that the balance between proteases and protease-inhibitors system plays a key role in maintaining cellular and tissue homeostasis. Indeed, its alteration has been involved in many ocular and systemic diseases.
Nicola Pescosolido, Andrea Barbato, Antonia Pascarella, Rossella Giannotti, Martina Genzano, Marcella Nebbioso   +5 more
doaj   +1 more source

Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin

Toxins, 2021
Iota-toxin from Clostridium perfringens type E is a binary toxin composed of two independent proteins: actin-ADP-ribosylating enzyme component, iota-a (Ia), and binding component, iota-b (Ib).
Masahiro Nagahama, Keiko Kobayashi, Masaya Takehara   +2 more
doaj   +1 more source

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24. [PDF]

, 2016
Off-target binding of hydrophobic drugs can lead to unwanted side effects, either through specific or non-specific binding to unintended membrane protein targets.
Carpenter, Elisabeth P, Gault, Joseph, Marcoux, Julien, Mehmood, Shahid, Michaelis, Susan, Quigley, Andrew, Robinson, Carol V, Young, Stephen G   +7 more
core   +2 more sources

Hepatitis C virus drugs that inhibit SARS-CoV-2 papain-like protease synergize with remdesivir to suppress viral replication in cell culture

Cell Reports, 2021
Summary: Effective control of COVID-19 requires antivirals directed against SARS-CoV-2. We assessed 10 hepatitis C virus (HCV) protease-inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate binding
Khushboo Bafna, Kris White, Balasubramanian Harish, Romel Rosales, Theresa A. Ramelot, Thomas B. Acton, Elena Moreno, Thomas Kehrer, Lisa Miorin, Catherine A. Royer, Adolfo García-Sastre, Robert M. Krug, Gaetano T. Montelione   +12 more
doaj  

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source