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Microbial proteases and their applications

open access: yesFrontiers in Microbiology, 2023
Proteases (proteinases or peptidases) are a class of hydrolases that cleave peptide chains in proteins. Endopeptidases are a type of protease that hydrolyze the internal peptide bonds of proteins, forming shorter peptides; exopeptidases hydrolyze the ...
Peng Song   +6 more
semanticscholar   +1 more source

Proteases [PDF]

open access: yesCurrent Protocols in Protein Science, 2000
AbstractThe processes of growth and remodeling of cells and tissues in multicellular organisms require the breakdown of old protein molecules, in concert with the synthesis of new ones. For example, many newly‐synthesized molecules require proteolytic processing to convert them to biologically active forms.
Jennifer L. Harris, Charles S. Craik
openaire   +5 more sources

EPCAM and TROP2 share a role in claudin stabilization and development of intestinal and extraintestinal epithelia in mice

open access: yesBiology Open, 2022
Epithelial cell adhesion molecule (EPCAM) is a transmembrane glycoprotein expressed on the surface of most epithelial and epithelium-derived tumor cells and reported to regulate stability of epithelial tight junction proteins, claudins.
Roman Szabo   +3 more
doaj   +1 more source

Multi-omics analyses of the Ulcerative Colitis gut microbiome link Bacteroides vulgatus proteases with disease severity

open access: yesNature Microbiology, 2021
Ulcerative colitis (UC) is driven by disruptions in host–microbiota homoeostasis, but current treatments exclusively target host inflammatory pathways. To understand how host–microbiota interactions become disrupted in UC, we collected and analysed six ...
R. Mills   +22 more
semanticscholar   +1 more source

Peptidases: promising antifungal targets of the human fungal pathogen, Cryptococcus neoformans

open access: yesFACETS, 2022
Cryptococcus neoformans is a globally important fungal pathogen, primarily inflicting disease on immunocompromised individuals. The widespread use of antifungal agents in medicine and agriculture supports the development of antifungal resistance through ...
Davier Gutierrez-Gongora   +1 more
doaj   +1 more source

Microbial proteases: ubiquitous enzymes with innumerable uses

open access: yes3 Biotech, 2021
Proteases are ubiquitous enzymes, having significant physiological roles in both synthesis and degradation. The use of microbial proteases in food fermentation is an age-old process, which is today being successfully employed in other industries with the
Preeti Solanki   +4 more
semanticscholar   +1 more source

Platelet-activating factor and protease-activated receptor 2 cooperate to promote neutrophil recruitment and lung inflammation through nuclear factor-kappa B transactivation

open access: yesScientific Reports, 2023
Although it is well established that platelet-activated receptor (PAF) and protease-activated receptor 2 (PAR2) play a pivotal role in the pathophysiology of lung and airway inflammatory diseases, a role for a PAR2-PAFR cooperation in lung inflammation ...
Irismara Sousa Silva   +11 more
doaj   +1 more source

Genetic detection to Aeromonas hydrophila proteolytic activity in milk samples (cows, buffaloes and goats) in Basra governorate [PDF]

open access: yesIraqi Journal of Veterinary Sciences, 2020
This study aim is to determine the incidence and the virulence of Aeromonas hydrophila in raw milk, randomly collected from Basra governorate by using of polymerase chain reaction (PCR) technique.
Rawa B Banay
doaj   +1 more source

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