Results 1 to 10 of about 331,217 (249)

EPCAM and TROP2 share a role in claudin stabilization and development of intestinal and extraintestinal epithelia in mice

Biology Open, 2022
Epithelial cell adhesion molecule (EPCAM) is a transmembrane glycoprotein expressed on the surface of most epithelial and epithelium-derived tumor cells and reported to regulate stability of epithelial tight junction proteins, claudins.
Roman Szabo, Jerrold M. Ward, Ferruh Artunc, Thomas H. Bugge   +3 more
doaj   +1 more source

Peptidases: promising antifungal targets of the human fungal pathogen, Cryptococcus neoformans

FACETS, 2022
Cryptococcus neoformans is a globally important fungal pathogen, primarily inflicting disease on immunocompromised individuals. The widespread use of antifungal agents in medicine and agriculture supports the development of antifungal resistance through ...
Davier Gutierrez-Gongora, Jennifer Geddes-McAlister   +1 more
doaj   +1 more source

Platelet-activating factor and protease-activated receptor 2 cooperate to promote neutrophil recruitment and lung inflammation through nuclear factor-kappa B transactivation

Scientific Reports, 2023
Although it is well established that platelet-activated receptor (PAF) and protease-activated receptor 2 (PAR2) play a pivotal role in the pathophysiology of lung and airway inflammatory diseases, a role for a PAR2-PAFR cooperation in lung inflammation ...
Irismara Sousa Silva, Aline D. Almeida, Antônio C. M. Lima Filho, Weslley Fernandes-Braga, Ayslan Barra, Hortência M. C. Oliveira, Geovanni D. Cassali, Luciano S. A. Capettini, Gustavo B. Menezes, Jacqueline I. Alvarez-Leite, Maria F. Leite, André Klein   +11 more
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A Prototype Assay Multiplexing SARS-CoV-2 3CL-Protease and Angiotensin-Converting Enzyme 2 for Saliva-Based Diagnostics in COVID-19

Biosensors, 2023
With the current state of COVID-19 changing from a pandemic to being more endemic, the priorities of diagnostics will likely vary from rapid detection to stratification for the treatment of the most vulnerable patients. Such patient stratification can be
Vallabh Suresh, Daniel A. Sheik, Tyler C. Detomasi, Tianqi Zhao, Theresa Zepeda, Shyam Saladi, Ummadisetti Chinna Rajesh, Kaleb Byers, Charles S. Craik, Vincent Jo Davisson   +9 more
doaj   +1 more source

Toxoplasma Cathepsin Protease B and Aspartyl Protease 1 Are Dispensable for Endolysosomal Protein Digestion

mSphere, 2020
The lysosome-like vacuolar compartment (VAC) is a major site of proteolysis in the intracellular parasite Toxoplasma gondii. Previous studies have shown that genetic ablation of a VAC-residing cysteine protease, cathepsin protease L (CPL), resulted in ...
Christian McDonald, David Smith, Manlio Di Cristina, Geetha Kannan, Zhicheng Dou, Vern B. Carruthers   +5 more
doaj   +1 more source

Matriptase zymogen supports epithelial development, homeostasis and regeneration

BMC Biology, 2017
Background Matriptase is a membrane serine protease essential for epithelial development, homeostasis, and regeneration, as well as a central orchestrator of pathogenic pericellular signaling in the context of inflammatory and proliferative diseases ...
Stine Friis, Daniel Tadeo, Sylvain M. Le-Gall, Henrik Jessen Jürgensen, Katiuchia Uzzun Sales, Eric Camerer, Thomas H. Bugge   +6 more
doaj   +1 more source

Effect of accumulated resistance genes to Puccinia triticina on transfer of seed proteins [PDF]

Ratarstvo i Povrtarstvo, 2013
Eighteen wheat lines and varieties were classified in four groups according to different reactions to Puccinia triticina isolate of the race 77 at seedlings.
Jerković Zoran, Prijić Željana, Đurić Veselinka   +2 more
doaj   +1 more source

Structural basis of specific inhibition of tissue-type plasminogen activator by plasminogen activators inhibitor-1

Data in Brief, 2016
Thrombosis is a leading cause of death worldwide [1]. Recombinant tissue-type plasminogen activator (tPA) is the FDA-approved thrombolytic drug for ischemic strokes, myocardial infarction and pulmonary embolism.
Lihu Gong, Min Liu, Tu Zeng, Xiaoli Shi, Cai Yuan, Peter A. Andreasen, Mingdong Huang   +6 more
doaj   +1 more source

tPA promotes ADAMTS-4-induced CSPG degradation, thereby enhancing neuroplasticity following spinal cord injury

Neurobiology of Disease, 2014
Although tissue plasminogen activator (tPA) is known to promote neuronal remodeling in the CNS, no mechanism of how this plastic function takes place has been reported so far.
Sighild Lemarchant, Mathilde Pruvost, Marie Hébert, Maxime Gauberti, Yannick Hommet, Aurélien Briens, Eric Maubert, Yatma Gueye, François Féron, Didier Petite, Marcel Mersel, Jean-Claude do Rego, Hubert Vaudry, Jari Koistinaho, Carine Ali, Véronique Agin, Evelyne Emery, Denis Vivien   +17 more
doaj   +1 more source

Lipid-based nanocarriers for oral delivery of peptides☆

Oilseeds and fats, crops and lipids, 2022
Therapeutic peptides can treat a wide variety of diseases with selective and potent action. Their oral bioavailability is strongly limited by an important proteolytic activity in the intestinal lumen and poor permeation across the intestinal border.
Dumont Camille
doaj   +1 more source