Results 11 to 20 of about 771,571 (414)
In silico prediction of mutant HIV-1 proteases cleaving a target sequence [PDF]
PLOS ONE Volume:9 Issue: 5 Page: e95833 (2014), 2014 HIV-1 protease represents an appealing system for directed enzyme re-design, since it has various different endogenous targets, a relatively simple structure and it is well studied. Recently Chaudhury and Gray (Structure (2009) 17: 1636 -- 1648) published a computational algorithm to discern the specificity determining residues of HIV-1 protease.
De Vico, Luca +3 more
arxiv +4 more sources
Convergent dynamics in the protease enzymatic superfamily [PDF]
J. Am. Chem. Soc. 128, 9766-9772 (2006), 2006 Proteases regulate various aspects of the life cycle in all organisms by cleaving specific peptide bonds. Their action is so central for biochemical processes that at least 2% of any known genome encodes for proteolytic enzymes. Here we show that selected proteases pairs, despite differences in oligomeric state, catalytic residues and fold, share a ...
Carloni, Paolo +3 more
arxiv +3 more sources
Protease inhibitors targeting the main protease and papain-like protease of coronaviruses [PDF]
Expert Opinion on Therapeutic Patents, 2020 The two cysteine proteases from the coronaviruses, which produced deadly outbreaks in the last two decades, SARS CoV-1/2, and MERS, the main protease (Mpro) and the papain-like protease (PLP) are conserved among the three pathogens and started to be considered as exciting drug targets for developing antivirals.We review the drug design landscape in the
Capasso, Clemente +2 more
openaire +4 more sources
Cysteine Cathepsins and Their Prognostic and Therapeutic Relevance in Leukemia
Annals of the National Academy of Medical Sciences (India), 2021 Cysteine cathepsins are lysosomal proteases that require Cys-His ion pair in their catalytic site for enzymatic activity. While their aberrant expression and oncogenic functions have been widely reported in solid tumors, recent findings suggest that ...
Mohit Arora +2 more
doaj +1 more source
mSphere, 2020 The lysosome-like vacuolar compartment (VAC) is a major site of proteolysis in the intracellular parasite Toxoplasma gondii. Previous studies have shown that genetic ablation of a VAC-residing cysteine protease, cathepsin protease L (CPL), resulted in ...
Christian McDonald +5 more
doaj +1 more source
Pharmacology Research & Perspectives, 2021 As the death toll of Coronavirus disease 19 (COVID‐19) continues to rise worldwide, it is imperative to explore novel molecular mechanisms for targeting SARS‐CoV‐2.
Ismail A. El‐Shimy +3 more
doaj +1 more source
FIBRINOGEN-SPECIFIC PROTEASE IN THE Vipera renardi SNAKE VENOM [PDF]
Biotechnologia Acta, 2023 Aim. To search fibrinogenolytic enzymes among protein components of Vipera renardi snake venom. Methods. Venom of V. renardi as the lyophilized powder was supplied by Trypillia serpentarium.
K.V. BAIDAKOVA +2 more
doaj +1 more source
Lipid-based nanocarriers for oral delivery of peptides☆
Oilseeds and fats, crops and lipids, 2022 Therapeutic peptides can treat a wide variety of diseases with selective and potent action. Their oral bioavailability is strongly limited by an important proteolytic activity in the intestinal lumen and poor permeation across the intestinal border.
Dumont Camille
doaj +1 more source
Bioconversion of poultry residues for the production of proteases by Aspergillus sp. isolated from Amazonian forest soil [PDF]
Ciência Rural, 2023 : Feathers are by-products that are generated in significant quantities by the poultry industry. Microbial bioconversion has been investigated as a promising strategy for the processing of feathers, since, along with the degradation of these keratinous ...
Thaylanna Cavalcante Correia +3 more
doaj +1 more source
Matriptase zymogen supports epithelial development, homeostasis and regeneration
BMC Biology, 2017 Background Matriptase is a membrane serine protease essential for epithelial development, homeostasis, and regeneration, as well as a central orchestrator of pathogenic pericellular signaling in the context of inflammatory and proliferative diseases ...
Stine Friis +6 more
doaj +1 more source