Results 171 to 180 of about 3,813 (208)
Enzymatic Formation of Protectin Dx and Its Production by Whole-Cell Reaction Using Recombinant Lipoxygenases [PDF]
Catalysts, 2022 In the human body, docosahexaenoic acid (DHA) contained in fish oil is converted to trace amounts of specialized pro-resolving mediators (SPMs) as the principal bioactive metabolites for their pharmacological effects.
Kyung-Chul Shin +2 more
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The Lipid Mediator Protectin D1 Inhibits Influenza Virus Replication and Improves Severe Influenza [PDF]
Cell, 2013 SummaryInfluenza A viruses are a major cause of mortality. Given the potential for future lethal pandemics, effective drugs are needed for the treatment of severe influenza such as that caused by H5N1 viruses.
Jun Katahira, , Shota Nakamura
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Protectin D1 reduces imiquimod-induced psoriasiform skin inflammation
International Immunopharmacology, 2021Specialized proresolving mediators are enzymatically oxygenated natural molecules derived from polyunsaturated fatty acids and are considered novel. These novel mediators include lipoxins from arachidonic acid, resolvins and protectins from omega-3 essential fatty acids, and new maresins.
Weon Ju Lee, Jinjoo Kang, Jun Young Kim
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Total synthesis of the antiinflammatory and proresolving protectin D1
Tetrahedron Letters, 2011Stereoselective total synthesis of protectin D1 was completed through construction of the Z,E,E-triene structure by using the Suzuki coupling between the vinyl borane (C13–C22) and the vinyl iodide (C1–C12). The Z-enyne, the acetylene precursor of the vinyl borane was synthesized from optically active γ-TMS allylic alcohol in a straightforward way.
Narihito Ogawa, Yuichi Kobayashi
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Resolvins and protectins in the termination program of acute inflammation
Trends in Immunology, 2007The physiological resolution of a well-orchestrated inflammatory response is essential to maintain homeostasis. Therefore, gaining a comprehensive understanding in molecular terms of the events that direct the termination of acute inflammation is imperative.
Amiram, Ariel, Charles N, Serhan
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Immunolocalization of protectin (CD59) and macrophages in polymyositis and dermatomyositis
Journal of Neuroimmunology, 2004Immunohistochemical stainings for protectin (CD59) and for the macrophage/monocyte antigen were performed in muscle specimens of polymyositis (PM) and dermatomyositis (DM) patients. In control muscles, a granular immunostaining of CD59 at the surface of 10-15% from among muscle fibers and an intense reaction in endothelia of blood vessels were noted ...
Hanna, Gendek-Kubiak, Ewa G, Gendek
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Lipoxins, resolvins and protectins: new leads for the treatment of asthma
Expert Opinion on Drug Discovery, 2008The pathobiology of asthma is characterized by the production of pro-inflammatory eicosanoids that play important roles in regulating airway responses. Recognition of the biosynthetic pathways and sites of action for 5-lipoxygenase-derived leukotrienes has led to the successful development of two different classes of asthma therapeutics.In this review,
Oliver, Haworth, Bruce D, Levy
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Protectins in Argentine Mollusks: Immunological and Immunochemical Aspects
1975Protectins and agglutinins in several organs, fluids and spawn from Argentine terrestrial and fresh-water gastropod species were examined. Differences or analogies with vertebrate immunoglobulin serological behaviour are summarized. Individual or group variability and the evolutionary meaning of the reproductive system-linked and the Ca++ ion-linked ...
M, Palatnik +3 more
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Novel Chemical Mediators in the Resolution of Inflammation: Resolvins and Protectins
Anesthesiology Clinics of North America, 2006Resolvins and protectins are new families consisting of distinct chemical series of lipid-derived mediators, each with unique structures and apparent complementary anti-inflammatory actions. Both families of compounds, Rv and protectins, are also generated when aspirin is given in mammalian systems in their respective epimeric forms.
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Mediator Lipidomics: Search Algorithms for Eicosanoids, Resolvins, and Protectins
2007Within the domain of lipidomics, lipid mediator lipidomics and informatics is an exciting area because of the important roles of lipid-derived mediators in health and disease. It is well-appreciated that arachidonic acid is a precursor to potent bioactive mediators, such as prostaglandins, leukotrienes, and lipoxins.
Charles N, Serhan +3 more
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