Results 11 to 20 of about 798,140 (253)
Frontiers in Molecular Biosciences, 2020 In bacterial cells we find a variety of interacting macromolecules, among them RNAs and proteins. Not only small regulatory RNAs (sRNAs), but also small proteins have been increasingly recognized as regulators of bacterial gene expression.
Inam Ul Haq +2 more
doaj +1 more source
Protein-RNA interactions: a structural analysis [PDF]
Nucleic Acids Research, 2001 A detailed computational analysis of 32 protein-RNA complexes is presented. A number of physical and chemical properties of the intermolecular interfaces are calculated and compared with those observed in protein-double-stranded DNA and protein-single-stranded DNA complexes.
Jones, S +4 more
openaire +4 more sources
PRD: A protein–RNA interaction database [PDF]
Bioinformation, 2012 Although protein-RNA interactions (PRIs) are involved in various important cellular processes, compiled data on PRIs are still limited. This contrasts with protein-protein interactions, which have been intensively recorded in public databases and subjected to network level analysis.
Fujimori, Shigeo +4 more
openaire +2 more sources
Computational tools to study RNA-protein complexes
Frontiers in Molecular Biosciences, 2022 RNA is the key player in many cellular processes such as signal transduction, replication, transport, cell division, transcription, and translation. These diverse functions are accomplished through interactions of RNA with proteins.
Sneha Bheemireddy +5 more
doaj +1 more source
High-throughput characterization of protein-RNA interactions [PDF]
Briefings in Functional Genomics, 2014 RNA-binding proteins (RBPs) are important regulators of eukaryotic gene expression. Genomes typically encode dozens to hundreds of proteins containing RNA-binding domains, which collectively recognize diverse RNA sequences and structures. Recent advances in high-throughput methods for assaying the targets of RBPs in vitro and in vivo allow large-scale ...
Cook, Kate B. +2 more
openaire +2 more sources
RNA Proximity Labeling: A New Detection Tool for RNA–Protein Interactions
Molecules, 2021 Multiple cellular functions are controlled by the interaction of RNAs and proteins. Together with the RNAs they control, RNA interacting proteins form RNA protein complexes, which are considered to serve as the true regulatory units for post ...
Ronja Weissinger +4 more
doaj +1 more source
Predictions of protein–RNA interactions
WIREs Computational Molecular Science, 2012 AbstractRibonucleoprotein interactions play important roles in a wide variety of cellular processes, ranging from transcriptional and posttranscriptional regulation of gene expression to host defense against pathogens. High throughput experiments to identify RNA–protein interactions provide information about the complexity of interaction networks, but ...
Cirillo D., Agostini F., Tartaglia G. G.
openaire +1 more source
Essential Assembly Factor Rpf2 Forms Novel Interactions within the 5S RNP in
mSphere, 2017 Ribosome biogenesis is a highly complex and conserved cellular process that is responsible for making ribosomes. During this process, there are several assembly steps that function as regulators to ensure proper ribosome formation.
Anyango D. Kamina +3 more
doaj +1 more source
Zooming in on protein-RNA interactions: a multi-level workflow to identify interaction partners. [PDF]
Biochem Soc Trans, 2020 Interactions between proteins and RNA are at the base of numerous cellular regulatory and functional phenomena. The investigation of the biological relevance of non-coding RNAs has led to the identification of numerous novel RNA-binding proteins (RBPs). However, defining the RNA sequences and structures that are selectively recognised by an RBP remains
Colantoni A +4 more
europepmc +4 more sources
Protein-RNA interactions: structural characteristics and hotspot amino acids. [PDF]
RNA, 2018 Structural information about protein–RNA complexes supports the understanding of crucial recognition processes in the cell, and it can allow the development of high affinity ligands to interfere with these processes. In this respect, the identification of amino acid hotspots is particularly important.
Krüger DM, Neubacher S, Grossmann TN.
europepmc +7 more sources