Results 221 to 230 of about 798,140 (253)

Computational Modeling of Protein-RNA Interactions

Proceedings of the 8th ACM International Conference on Bioinformatics, Computational Biology,and Health Informatics, 2017
Protein-RNA interactions, mediated through both RNA sequence and structure, play vital role in all cellular processes. In recent years, technologies have been developed to measure these interactions in high-throughput manner. Researchers would like to infer accurate models from the experimental data in order to predict new interactions and better ...
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Characterization of hnRNP K Protein–RNA Interactions

Journal of Molecular Biology, 2004
The heterogeneous nuclear ribonucleoprotein K protein is an RNA-binding protein found in several subcellular compartments where it is thought to be involved in signaling multiple processes that compose gene expression. K protein contains three K homology (KH) domains that mediate RNA-binding.
Karolina, Klimek-Tomczak, Lucjan S, Wyrwicz, Sanjeev, Jain, Karol, Bomsztyk, Jerzy, Ostrowski   +4 more
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Protein-RNA interactions in 20S U5 snRNPs

Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1991
The interaction of the U5-specific polypeptides with U5 snRNA was investigated by comparison of the differential accessibility towards nucleases and dimethylsulfate of defined regions of U5 snRNA in purified 20S and 10S U5 snRNPs. While 20S U5 snRNPs contain eight U5-specific proteins in addition to the common proteins, the 10S U5 snRNPs contain only ...
M, Bach, R, Lührmann
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Transcriptome-Wide Mapping of Protein–RNA Interactions

2020
RNA and RNA-binding proteins (RBPs) control multiple biological processes. The spatial and temporal arrangement of RNAs and RBPs underlies the delicate regulation of these processes. The strategy called CLIP-seq (cross-linking and immunoprecipitation) has been developed to capture endogenous protein-RNA interactions with UV cross-linking followed by ...
Xianju, Bi, Xiaohua, Shen
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Computational methods for prediction of protein–RNA interactions

Journal of Structural Biology, 2012
Understanding the molecular mechanism of protein-RNA recognition and complex formation is a major challenge in structural biology. Unfortunately, the experimental determination of protein-RNA complexes by X-ray crystallography and nuclear magnetic resonance spectroscopy (NMR) is tedious and difficult.
Tomasz, Puton, Lukasz, Kozlowski, Irina, Tuszynska, Kristian, Rother, Janusz M, Bujnicki   +4 more
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Protein‐RNA interactions during TMV assembly

Journal of Supramolecular Structure, 1979
AbstractA review of the structural studies of tobacco mosaic virus (TMV) is given. TMV is essentially a flat helical microcrystal with 16 1/3 subunits per turn. A single strand of RNA runs along the helix and is deeply embedded in the protein. The virus particles form oriented gels from which high‐resolution X‐ray fiber diffraction data can be obtained.
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Protein–RNA interactions: Structural analysis and functional classes

Proteins: Structure, Function, and Bioinformatics, 2007
AbstractA data set of 89 protein–RNA complexes has been extracted from the Protein Data Bank, and the nucleic acid recognition sites characterized through direct contacts, accessible surface area, and secondary structure motifs. The differences between RNA recognition sites that bind to RNAs in functional classes has also been analyzed. Analysis of the
Ellis, Jonathan J., Broom, Mark, Jones, Susan   +2 more
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Mapping Protein-RNA Interactions by CLIP

Materials and Methods, 2011
One of the challenges of systems biology is to understand how the interplay of individual cellular components gives rise to cellular behaviors such as cell division, apoptosis and differentiation. Generally, the expression of genes encoding proteins that are part of the same pathway is regulated in a coordinated manner, either at the level of ...
Martin, Gorges, Gruber, Andreas R., Zavolan, Mihaela   +2 more
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Cyclic constraint on the protein-RNA/DNA interaction

Physical Biology
Abstract The engagement of protein and ribonucleic acid (RNA)/deoxyribonucleic acid (DNA) is examined in three varied conformations of protein molecules and two different configurations of RNA/DNA, namely finite and cyclic. This analysis emphasizes density of states (DOS) and band structures by making use of a tight-binding Hamiltonian ...
Hamze Mousavi, Ronak Emami
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Prediction and Dissection of Protein-RNA Interactions by Molecular Descriptors

Current Topics in Medicinal Chemistry, 2015
Protein-RNA interactions play crucial roles in numerous biological processes. However, detecting the interactions and binding sites between protein and RNA by traditional experiments is still time consuming and labor costing. Thus, it is of importance to develop bioinformatics methods for predicting protein-RNA interactions and binding sites.
Zhi-Ping, Liu, Luonan, Chen
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