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Recapitulating Endochondral Ossification for Bone Repair: From Development to Engineering Strategy
Advanced Healthcare Materials, EarlyView.This review summarizes the developmental basis of endochondral ossification (ECO) and its applications in bone tissue engineering (BTE). It first outlines the key biological processes and signaling pathways underlying ECO, then discusses biomaterial‐based engineering strategies derived from these principles, and finally highlights future directions for
Yiqi Su +8 more
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Biolayer Interferometry: Protein–RNA Interactions
2021RNA-binding proteins often contain multiple RNA-binding domains connected by short flexible linkers. This domain arrangement allows the protein to bind the RNA with greater affinity and specificity than would be possible with individual domains and sometimes to remodel its structure. It is therefore important to understand how multiple modules interact
Stephen R, Martin +2 more
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PROTEIN-RNA INTERACTIONS IN BACTERIAL RIBOSOMES
Acta Endocrinologica, 1973ABSTRACT There are several ribosomal proteins which can bind specifically to the three ribosomal RNA's of E. coli. Some structural properties of these proteins and of the RNA are described together with the optimal conditions for binding. Evidence for conformational changes occurring in some proteins, and in the RNA's during binding, is also ...
R A, Garrett, H G, Wittmann
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Small-molecule modulators of protein–RNA interactions
Current Opinion in Chemical Biology, 2022Protein-RNA interactions (PRIs) play crucial roles in diverse cellular pathways, from transcription to liquid-liquid phase separation, and its dysregulation is associated with a wide range of human disorders. Therefore, there is great emphasis on discovering small-molecule modulators that target unexplored PRIs by developing robust PRI assays.
Wan Gi Byun +2 more
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Chromodomains are protein–RNA interaction modules
Nature, 2000In Drosophila, compensation for the reduced dosage of genes located on the single male X chromosome involves doubling their expression in relation to their counterparts on female X chromosomes. Dosage compensation is an epigenetic process involving the specific acetylation of histone H4 at lysine 16 by the histone acetyltransferase MOF. Although MOF is
A, Akhtar, D, Zink, P B, Becker
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PRIdictor: Protein–RNA Interaction predictor
Biosystems, 2016Several computational methods have been developed to predict RNA-binding sites in protein, but its inverse problem (i.e., predicting protein-binding sites in RNA) has received much less attention. Furthermore, most methods that predict RNA-binding sites in protein do not consider interaction partners of a protein.
Narankhuu Tuvshinjargal +3 more
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Protein–RNA interactions: new genomic technologies and perspectives [PDF]
Nature Reviews Genetics, 2012 RNA-binding proteins are key players in the regulation of gene expression. In this Progress article, we discuss state-of-the-art technologies that can be used to study individual RNA-binding proteins or large complexes such as the ribosome. We also describe how these approaches can be used to study interactions with different types of RNAs, including ...
Julian KÖNIG +2 more
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NMR Studies of Protein–RNA Interactions
2011This chapter describes the preparation of NMR quantities of RNA purified to single-nucleotide resolution for protein-RNA interaction studies. The protocol is easily modified to make nucleotide-specific isotopically labeled RNAs or uniformly labeled RNA fragments for ligation to generate segmentally labeled RNAs.
Carla A, Theimer +2 more
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irCLIP platform for efficient characterization of protein–RNA interactions [PDF]
Nature Methods, 2016 The complexity of transcriptome-wide protein-RNA interaction networks is incompletely understood. While emerging studies are greatly expanding the known universe of RNA-binding proteins, methods for the discovery and characterization of protein-RNA interactions remain resource intensive and technically challenging. Here we introduce a UV-C crosslinking
Brian J Zarnegar +2 more
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Methods for Identification of Protein-RNA Interaction
2018The importance of RNA-protein interactions in regulation of mRNA and non-coding RNA function is increasingly appreciated. With the development of next generation high-throughput sequencing technologies, a variety of methods have been proposed to comprehensively identify RNA-protein interactions.
Juan, Xu +4 more
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