Systematic Evaluation of Electrophile Reactivity and Stability for Covalent DNA‐Encoded Libraries
Helvetica Chimica Acta, EarlyView.To facilitate the design and construction of covalent DNA‐encoded libraries, a set of 59 electrophilic compounds from six different classes was systematically investigated for DNA‐conjugatability, S‐ and N‐nucleophile reactivity, as well as on‐DNA stability.
Johanna Puff +11 more
wiley +1 more source
Comparison of Protein Acetyltransferase Action of CRTAase with the Prototypes of HAT
The Scientific World Journal, 2014 Our laboratory is credited for the discovery of enzymatic acetylation of protein, a phenomenon unknown till we identified an enzyme termed acetoxy drug: protein transacetylase (TAase), catalyzing the transfer of acetyl group from polyphenolic acetates to
Prija Ponnan +10 more
doaj +1 more source
Journal of Lipid Research, 2016 The covalent attachment of a 14-carbon aliphatic tail on a glycine residue of nascent translated peptide chains is catalyzed in human cells by two N-myristoyltransferase (NMT) enzymes using the rare myristoyl-CoA (C14-CoA) molecule as fatty acid donor ...
Eric Soupene +7 more
doaj +1 more source
The Brain Protein Acylation System Responds to Seizures in the Rat Model of PTZ-Induced Epilepsy. [PDF]
Int J Mol Sci, 2022 Zavileyskiy LG +7 more
europepmc +1 more source
Screening anticancer peptides performance in organotypic prostate tumor‐stroma 3D models
International Journal of Cancer, EarlyView.What's New? Peptide‐based drugs have emerged as promising anticancer therapies for their potential to disrupt protein–protein interactions. In this study, the authors developed a physiomimetic human 3D prostate cancer spheroid model to assess the efficacy of the CAVPENET peptide in inhibiting tumor growth. Upon incubation with CAVPENET, prostate cancer
Bárbara Matos +7 more
wiley +1 more source
Acylation – A New Means to Control Traffic Through the Golgi
Frontiers in Cell and Developmental Biology, 2019 The Golgi is well known to act as center for modification and sorting of proteins for secretion and delivery to other organelles. A key sorting step occurs at the trans-Golgi network and is mediated by protein adapters. However, recent data indicate that
Andreas M. Ernst +3 more
doaj +1 more source
A bioorthogonal chemical reporter for fatty acid synthase-dependent protein acylation. [PDF]
J Biol Chem, 2021 Karthigeyan KP +6 more
europepmc +1 more source
Gut microbiome‐derived metabolites show promise in cancer research and therapy
Interdisciplinary Medicine, EarlyView.The metabolites produced by the gut microbiome, which are subject to regulation by multiple factors, play a pivotal role in the progression of various types of cancer. These metabolites not only function as potential biomarkers for the early detection and monitoring of tumor development, but also actively participate in cancer therapeutic processes ...
Kangjie Yang +4 more
wiley +1 more source
Biochemical Mechanisms of Sirtuin-Directed Protein Acylation in Hepatic Pathologies of Mitochondrial Dysfunction. [PDF]
Cells, 2022 McGinnis CD +4 more
europepmc +1 more source
Data‐Driven Engineering of Thermostable Collagen‐Mimetic Peptoid Triple Helices
Macromolecular Rapid Communications, EarlyView.Data‐driven active learning discovery of collagen‐mimetic peptoids capable of forming a thermostable collagen‐like triple helix using computational screening followed by experimental validation. ABSTRACT Collagen‐mimetic peptides (CMPs) are engineered molecules designed to replicate the triple‐helical structure of natural collagen.
Alex Berlaga +6 more
wiley +1 more source