Results 121 to 130 of about 287,910 (304)

Transmissibility versus Pathogenicity of Self-Propagating Protein Aggregates

, 2019
The prion-like spreading and accumulation of specific protein aggregates appear to be central to the pathogenesis of many human diseases, including Alzheimer’s and Parkinson’s.
Byron Caughey, Allison Kraus
core   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Formation, structure and properties of whey protein aggregates

, 2015
International audienceThe native whey proteins have been intensively used in a multitude of food applications due to their high nutritional, biological, and techno-functional properties.
Bouhallab, Said, Famelart, Marie-Hélène, Guyomarc'H, Fanny, Croguennec, Thomas   +3 more
core  

Proteotoxic stress induces phosphorylation of p62/SQSTM1 by ULK1 to regulate selective autophagic clearance of protein aggregates. [PDF]

, 2015
Disruption of proteostasis, or protein homeostasis, is often associated with aberrant accumulation of misfolded proteins or protein aggregates. Autophagy offers protection to cells by removing toxic protein aggregates and injured organelles in response ...
Mondira Kundu (696499), Zhenyu Yue, Lim, Junghyun, Wenchao Liu, Young J Oh, Liu, W, M Lenard Lachenmayer, Rong Wang, Wenchao Liu (330964), Yanxiang Zhao (638440), Masaaki Komatsu, Lim, J, Masaaki Komatsu (233763), Wu, Shuai, Komatsu, M, Zhao, Yanxiang, Kundu, M, Junghyun Lim, Wang, R, Zhao, Y, Wu, S, Mondira Kundu, Shuai Wu, Young J. Oh (696500), Oh, YJ, Yue, Z, Wang, Rong, M. Lenard Lachenmayer (696498), Yanxiang Zhao, Lachenmayer, ML, Zhenyu Yue (198875), Kundu, Mondira, Shuai Wu (401994), Junghyun Lim (696497), Rong Wang (59795), Komatsu, Masaaki, Yue, Zhenyu, Lachenmayer, Lenard, Liu, Wenchao, Oh, Young J   +39 more
core   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Protein oleogels from heat-set whey protein aggregates

, 2017
In this research we use heat-set whey protein aggregates (diameter ∼ 200 nm) as novel building blocks for structure formation in liquid oil to form oleogels.
de Vries, Auke, Vries, Auke, de, Linden, Erik, van der, Wesseling, Anne, Scholten, Elke, van der Linden, Erik   +5 more
core   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Protein aggregation: folding aggregates, inclusion bodies and amyloid

Folding and Design, 1998
Aggregation results in the formation of inclusion bodies, amyloid fibrils and folding aggregates. Substantial data support the hypothesis that partially folded intermediates are key precursors to aggregates, that aggregation involves specific intermolecular interactions and that most aggregates involve beta sheets.
openaire   +2 more sources