Results 1 to 10 of about 2,014,238 (321)

Urinary Protein Array Analysis to Identify Key Inflammatory Markers in Children with IgA Vasculitis Nephritis [PDF]

Children, 2022
Chronic kidney disease is a recognised complication of immunoglobulin A vasculitis, (IgAV; formerly Henoch–Schonlein purpura—HSP). The pathophysiology of IgAV and why some patients develop significant renal involvement remains largely unknown ...
Julien Marro, Andrew J. Chetwynd, Rachael D. Wright, Silothabo Dliso, Louise Oni   +4 more
doaj   +5 more sources

Analysis of protein interaction and function with a 3-dimensional MALDI-MS protein array [PDF]

BioTechniques, 2005
Protein profiling and characterization of protein interactions in biological samples ultimately require indicator-free methods of signal detection, which likewise offer an opportunity to distinguish specific interactions from nonspecific protein binding.
Igor M. Gavin, Alexander Kukhtin, David Glesne, Daniel Schabacker, Darrell P. Chandler   +4 more
doaj   +5 more sources

Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis [PDF]

Biomolecules, 2022
Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA.
Jianqiang Wu, Wei Wang, Ting Xie, Zhaoran Chen, Lei Zhou, Xiaohong Song, Haoxuan Kan, Yanze Lv, Lianglin Wu, Fangda Li, Dan Yang, Yuexin Chen, Bao Liu, Yuehong Zheng   +13 more
doaj   +3 more sources

Discovery of crucial cytokines associated with abdominal aortic aneurysm formation by protein array analysis. [PDF]

Exp Biol Med (Maywood), 2019
As a common disease, abdominal aortic aneurysm (AAA) features permanently progressively dilated abdominal aorta. Various cytokines are implicated in AAA pathogenesis.
Li Y, Yang D, Sun B, Zhang X, Li F, Liu Z, Zheng Y.   +6 more
europepmc   +4 more sources

Protein and Peptide Array Analysis of Autoimmune Disease [PDF]

BioTechniques, 2002
Molecular cloning, sequencing of the human genome, and other major advances in biomedical research have contributed substantially to our understanding of autoimmune disease.
William H. Robinson, Lawrence Steinman, Paul J. Utz   +2 more
doaj   +4 more sources

Reverse-phase protein array analysis to identify biomarker proteins in human pancreatic cancer. [PDF]

Dig Dis Sci, 2014
Pancreatic cancer is the fourth leading cause of cancer death in the United States. The high mortality rate of patients with pancreatic cancer is primarily due to the difficulty of early diagnosis and a lack of effective therapies. There is an urgent need to discover novel molecular targets for early diagnosis and new therapeutic approaches to improve ...
Huang YJ, Frazier ML, Zhang N, Liu Q, Wei C.   +4 more
europepmc   +5 more sources

RPPanalyzer Toolbox: An improved R package for analysis of reverse phase protein array data

BioTechniques, 2014
Analysis of large-scale proteomic data sets requires specialized software tools, tailored toward the requirements of individual approaches. Here we introduce an extension of an open-source software solution for analyzing reverse phase protein array (RPPA)
Silvia von der Heyde, Johanna Sonntag, Daniel Kaschek, Christian Bender, Johannes Bues, Astrid Wachter, Jens Timmer, Ulrike Korf, Tim Beißbarth   +8 more
doaj   +3 more sources

Discovery of crucial cytokines associated with deep vein thrombus formation by protein array analysis [PDF]

BMC Cardiovascular Disorders
Background Expanding the number of biomarkers is imperative for studying the etiology and improving venous thromboembolism prediction. In this study, we aimed to identify promising biomarkers or targeted therapies to improve the detection accuracy of ...
Qitao Wang, Junyu Chi, Wenjie Zeng, Fang Xu, Xin Li, Zhen Wang, Ming Qu   +6 more
doaj   +3 more sources

Analysis of Autoantibody Profiles in Osteoarthritis Using Comprehensive Protein Array Concepts

Journal of Proteome Research, 2014
Osteoarthritis (OA) is the most common rheumatic disease and one of the most disabling pathologies worldwide. To date, the diagnostic methods of OA are very limited, and there are no available medications capable of halting its characteristic cartilage degeneration.
Frauke Henjes, L. Lourido, Cristina Ruíz‐Romero, Juan Fernández‐Tajes, Jochen M. Schwenk, María González‐González, Francisco J. Blanco, Peter Nilsson, Manuel Fuentes   +8 more
semanticscholar   +7 more sources

Protein Array Based Interactome Analysis of Amyloid-β Indicates an Inhibition of Protein Translation

Journal of Proteome Research, 2011
Oligomeric amyloid-β is currently of interest in amyloid-β mediated toxicity and the pathogenesis of Alzheimer's disease. Mapping the amyloid-β interaction partners could help to discover novel pathways in disease pathogenesis. To discover the amyloid-β interaction partners, we applied a protein array with more than 8100 unique recombinantly expressed ...
Dezső P. Virók, Dóra Simon, Zsolt Bozsó, Róbert Rajkó, Zsolt Datki, Éva Bálint, Viktor Szegedi, Tamás Janáky, Botond Penke, Lívia Fülöp   +9 more
semanticscholar   +5 more sources