Results 1 to 10 of about 927,101 (310)
Protein and Peptide Array Analysis of Autoimmune Disease [PDF]
BioTechniques, 2002 Molecular cloning, sequencing of the human genome, and other major advances in biomedical research have contributed substantially to our understanding of autoimmune disease.
William H. Robinson +2 more
doaj +5 more sources
Analysis of protein interaction and function with a 3-dimensional MALDI-MS protein array [PDF]
BioTechniques, 2005 Protein profiling and characterization of protein interactions in biological samples ultimately require indicator-free methods of signal detection, which likewise offer an opportunity to distinguish specific interactions from nonspecific protein binding.
Igor M. Gavin +4 more
doaj +5 more sources
A lectin array-based methodology for the analysis of protein glycosylation [PDF]
Journal of Biochemical and Biophysical Methods, 2006 Glycosylation is the most versatile and one of the most abundant protein modifications. It has a structural role as well as diverse functional roles in many specific biological functions, including cancer development, viral and bacterial infections, and autoimmunity.
Rakefet Rosenfeld +9 more
openalex +5 more sources
Doubly stochastic continuous-time hidden Markov approach for analyzing genome tiling arrays [PDF]
Annals of Applied Statistics 2009, Vol. 3, No. 3, 1183-1203, 2008 Microarrays have been developed that tile the entire nonrepetitive genomes of many different organisms, allowing for the unbiased mapping of active transcription regions or protein binding sites across the entire genome.
Johnson, W. Evan +2 more
core +2 more sources
Protein expression profiling arrays: tools for the multiplexed high-throughput analysis of proteins. [PDF]
Proteome science, 2003 The completion of the human genome sequence has led to a rapid increase in genetic information. The invention of DNA microarrays, which allow for the parallel measurement of thousands of genes on the level of mRNA, has enabled scientists to take a more global view of biological systems.
Jens Sydor, Steffen Nock
openalex +4 more sources
Protein western array analysis in human pituitary tumours: insights and limitations [PDF]
Endocrine Related Cancer, 2008 The molecular analysis of pituitary tumours has received a great deal of attention, although the majority of studies have concentrated on the genome and the transcriptome. We aimed to study the proteome of human pituitary adenomas. A protein array using 1005 monoclonal antibodies was used to study GH-, corticotrophin- and prolactin-secreting as well as
Antônio Ribeiro‐Oliveira +13 more
openalex +5 more sources
Smartphone-Based Quantitative Analysis of Protein Array Signals for Biomarker Detection in Lupus [PDF]
Chemosensors, 2022 Fluorescence-based microarray offers great potential in clinical diagnostics due to its high-throughput capability, multiplex capabilities, and requirement for a minimal volume of precious clinical samples.
Guang Yang +5 more
doaj +2 more sources
Antibody Protein Array Analysis of the Tear Film Cytokines [PDF]
Optometry and Vision Science, 2008 Many bioactive proteins including cytokines are reported to increase in dry eye disease although the specific profile and concentration of inflammatory mediators varies considerably from study to study. In part, this variability results from inherent difficulties in quantifying low abundance proteins in a limited sample volume using relatively low ...
Shimin Li +7 more
openalex +3 more sources
Cluster analysis of protein array results via similarity of Gene Ontology annotation [PDF]
BMC Bioinformatics, 2006 Background With the advent of high-throughput proteomic experiments such as arrays of purified proteins comes the need to analyse sets of proteins as an ensemble, as opposed to the traditional one-protein-at-a-time approach.
Wolting Cheryl +2 more
doaj +2 more sources
In situ structural analysis of Golgi intracisternal protein arrays [PDF]
Proceedings of the National Academy of Sciences, 2015 Significance To our knowledge, this is the first detailed study of Golgi ultrastructure within unperturbed cells. Three intracisternal structures were identified, with implications for Golgi architecture and trafficking: ( i ) Bundles of filaments show how cargoes may oligomerize to increase their local ...
Benjamin D. Engel +5 more
openalex +7 more sources