Identification of Novel Plasma Biomarkers for Abdominal Aortic Aneurysm by Protein Array Analysis [PDF]
Biomolecules, 2022 Abdominal aortic aneurysm (AAA) is a potentially life-threatening disease that is common in the aging population. Currently, there are no approved diagnostic biomarkers or therapeutic drugs for AAA.
Jianqiang Wu +13 more
doaj +5 more sources
Urinary Protein Array Analysis to Identify Key Inflammatory Markers in Children with IgA Vasculitis Nephritis [PDF]
Children, 2022 Chronic kidney disease is a recognised complication of immunoglobulin A vasculitis, (IgAV; formerly Henoch–Schonlein purpura—HSP). The pathophysiology of IgAV and why some patients develop significant renal involvement remains largely unknown ...
Julien Marro +4 more
doaj +3 more sources
Protein and Peptide Array Analysis of Autoimmune Disease [PDF]
BioTechniques, 2002 Molecular cloning, sequencing of the human genome, and other major advances in biomedical research have contributed substantially to our understanding of autoimmune disease.
William H. Robinson +2 more
doaj +4 more sources
Reverse-phase protein array analysis to identify biomarker proteins in human pancreatic cancer. [PDF]
Dig Dis Sci, 2014 Pancreatic cancer is the fourth leading cause of cancer death in the United States. The high mortality rate of patients with pancreatic cancer is primarily due to the difficulty of early diagnosis and a lack of effective therapies. There is an urgent need to discover novel molecular targets for early diagnosis and new therapeutic approaches to improve ...
Huang YJ +4 more
europepmc +5 more sources
Analysis of protein interaction and function with a 3-dimensional MALDI-MS protein array [PDF]
BioTechniques, 2005 Protein profiling and characterization of protein interactions in biological samples ultimately require indicator-free methods of signal detection, which likewise offer an opportunity to distinguish specific interactions from nonspecific protein binding.
Igor M. Gavin +4 more
doaj +4 more sources
Discovery of crucial cytokines associated with abdominal aortic aneurysm formation by protein array analysis. [PDF]
Exp Biol Med (Maywood), 2019 As a common disease, abdominal aortic aneurysm (AAA) features permanently progressively dilated abdominal aorta. Various cytokines are implicated in AAA pathogenesis.
Li Y +6 more
europepmc +2 more sources
Antibody Protein Array Analysis of the Tear Film Cytokines [PDF]
Optometry and Vision Science, 2008 Many bioactive proteins including cytokines are reported to increase in dry eye disease although the specific profile and concentration of inflammatory mediators varies considerably from study to study. In part, this variability results from inherent difficulties in quantifying low abundance proteins in a limited sample volume using relatively low ...
Shimin, Li +7 more
openaire +3 more sources
RPPanalyzer: Analysis of reverse-phase protein array data [PDF]
Bioinformatics, 2010 Abstract Summary: RPPanalyzer is a statistical tool developed to read reverse-phase protein array data, to perform the basic data analysis and to visualize the resulting biological information. The R-package provides different functions to compare protein expression levels of different samples and to normalize the data.
Mannsperger, Heiko A. +4 more
openaire +4 more sources
RPPanalyzer Toolbox: An improved R package for analysis of reverse phase protein array data
BioTechniques, 2014 Analysis of large-scale proteomic data sets requires specialized software tools, tailored toward the requirements of individual approaches. Here we introduce an extension of an open-source software solution for analyzing reverse phase protein array (RPPA)
Silvia von der Heyde +8 more
doaj +2 more sources
Discovery of crucial cytokines associated with deep vein thrombus formation by protein array analysis [PDF]
BMC Cardiovascular DisordersBackground Expanding the number of biomarkers is imperative for studying the etiology and improving venous thromboembolism prediction. In this study, we aimed to identify promising biomarkers or targeted therapies to improve the detection accuracy of ...
Qitao Wang +6 more
doaj +2 more sources