Results 111 to 120 of about 2,270,992 (356)

Peptide array X-linking (PAX): a new peptide-protein identification approach. [PDF]

PLoS ONE, 2012
Many protein interaction domains bind short peptides based on canonical sequence consensus motifs. Here we report the development of a peptide array-based proteomics tool to identify proteins directly interacting with ligand peptides from cell lysates ...
Hirokazu Okada, Akiyoshi Uezu, Erik J Soderblom, M Arthur Moseley, Frank B Gertler, Scott H Soderling   +5 more
doaj   +1 more source

Protein array identification of protein markers for serodiagnosis of Mycobacterium tuberculosis infection

Scientific Reports, 2015
The lack of effective and accurate diagnostic tools contributes to the high prevalence of tuberculosis (TB) worldwide. The current serodiagnostics for TB are inadequate mainly due to lack of TB-specific antigens with highly accurate diagnosis.
Fangbin Zhou, Xin-dong Xu, Sijia Wu, Xiaobing Cui, L. Fan, Weiqing Pan   +5 more
semanticscholar   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Identification of long non-coding RNAs involved in neuronal development and intellectual disability [PDF]

, 2016
Recently, exome sequencing led to the identification of causal mutations in 16–31% of patients with intellectual disability (ID), leaving the underlying cause for many patients unidentified. In this context, the noncoding part of the human genome remains
D'haene, Eva, De Meyer, Tim, Jacobs, Eva, Menten, Björn, Vergult, Sarah, Volders, Pieter-Jan   +5 more
core   +1 more source

Rvisdiff: An R package for interactive visualization of differential expression

Frontiers in Bioinformatics
Rvisdiff is an R/Bioconductor package that generates an interactive interface for the interpretation of differential expression results. It creates a local web page that enables the exploration of statistical analysis results through the generation of ...
David Barrios, Carlos Prieto
doaj   +1 more source

Complementary DNA Expression Array Analysis Suggests a Lower Expression of Signal Transduction Proteins and Receptors in Cold and Hot Thyroid Nodules [PDF]

, 2001
Markus Eszlinger, Knut Krohn, Ralf Paschke   +2 more
openalex   +2 more sources

Early metastasis is characterized by Gr1+ cell dysregulation and is inhibited by immunomodulatory nanoparticles

Molecular Oncology, EarlyView.
Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma, Sophia M. Orbach, Kate V. Griffin, Kathryn Kang, Yining Zhang, Rebecca S. Pereles, Ian A. Schrack, Guillermo Escalona, Jacqueline S. Jeruss, Lonnie D. Shea   +9 more
wiley   +1 more source

Gene expression patterns in anterior pituitary associated with quantitative measure of oestrous behaviour in dairy cows [PDF]

, 2010
Intensive selection for high milk yield in dairy cows has raised production levels substantially but at the cost of reduced fertility, which manifests in different ways including reduced expression of oestrous behaviour.
Beerda, B., Frijters, A.C.J., Kommadath, A., Mulder, H.A., Pas, M.F.W., te, Smits, M.A., Veerkamp, R.F., Wit, A.A.C., de, Woelders, H.   +8 more
core   +2 more sources

Referencing cross-reactivity of detection antibodies for protein array experiments [version 2; referees: 1 approved, 2 approved with reservations]

F1000Research, 2017
Protein arrays are frequently used to profile antibody repertoires in humans and animals. High-throughput protein array characterisation of complex antibody repertoires necessitates the use of extensively validated secondary detection antibodies.
Darragh Lemass, Richard O'Kennedy, Gregor S. Kijanka   +2 more
doaj   +1 more source

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source