Strategies for analyzing highly enriched IP-chip datasets [PDF]
BMC Bioinformatics, 2009 Background Chromatin immunoprecipitation on tiling arrays (ChIP-chip) has been employed to examine features such as protein binding and histone modifications on a genome-wide scale in a variety of cell types.
Tavaré Simon +3 more
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Novel computational analysis of protein binding array data identifies direct targets of
BMC Bioinformatics, 2011 Background The creation of a complete genome-wide map of transcription factor binding sites is essential for understanding gene regulatory networks in vivo.
Kaestner Klaus H +4 more
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BMC Cardiovascular DisordersBackground Expanding the number of biomarkers is imperative for studying the etiology and improving venous thromboembolism prediction. In this study, we aimed to identify promising biomarkers or targeted therapies to improve the detection accuracy of ...
Qitao Wang +6 more
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RPPanalyzer Toolbox: An improved R package for analysis of reverse phase protein array data
BioTechniques, 2014 Analysis of large-scale proteomic data sets requires specialized software tools, tailored toward the requirements of individual approaches. Here we introduce an extension of an open-source software solution for analyzing reverse phase protein array (RPPA)
Silvia von der Heyde +8 more
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A Liquid Array Platform for the Multiplexed Analysis of Synthetic Molecule–Protein Interactions [PDF]
ACS Chemical Biology, 2013 Synthetic molecule microarrays, consisting of many different compounds spotted onto a planar surface such as modified glass or cellulose, have proven to be useful tools for the multiplexed analysis of small molecule- and peptide-protein interactions. However, these arrays are technically difficult to manufacture and use with high reproducibility and ...
Todd M. Doran, Thomas Kodadek
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A Label-Free Fluorescent Array Sensor Utilizing Liposome Encapsulating Calcein for Discriminating Target Proteins by Principal Component Analysis [PDF]
Sensors, 2017 A new fluorescent arrayed biosensor has been developed to discriminate species and concentrations of target proteins by using plural different phospholipid liposome species encapsulating fluorescent molecules, utilizing differences in permeation of the ...
Ryota Imamura +5 more
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Proteomic applications of surface plasmon resonance biosensors: analysis of protein arrays [PDF]
Experimental & Molecular Medicine, 2005 Proteomics is one of the most important issues in the post-genomic area, because it can greatly contribute to identifying protein biomarkers for disease diagnosis and drug screening. Protein array is a key technology for proteome researches and has been analyzed by various methods including fluorescence, mass spectrometry, atomic force microscopy and ...
Jong Seol Yuk, Kwon‐Soo Ha
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A Network-based Analysis of Polyanion-binding Proteins Utilizing Human Protein Arrays [PDF]
Journal of Biological Chemistry, 2007 The existence of interactions between many cellular proteins and various polyanionic surfaces within a cell is now well established. The functional role of such interactions, however, remains to be clearly defined. The existence of protein arrays, with a large selection of different kinds of proteins, provides a way to better address a number of ...
Nazila Salamat‐Miller +5 more
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Antibody Array Analysis with Label-based Detection and Resolution of Protein Size [PDF]
Molecular & Cellular Proteomics, 2008 Elements from DNA microarray analysis, such as sample labeling and micro-spotting of capture reagents, have been successfully adapted to multiplex measurements of soluble cytokines. Application in cell biology is hampered by the lack of mono-specific antibodies and the fact that many proteins occur in complexes.
Weiwei Wu +8 more
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Induction of CCL8/MCP-2 by mycobacteria through the activation of TLR2/PI3K/Akt signaling pathway. [PDF]
, 2012 Pleural tuberculosis (TB), together with lymphatic TB, constitutes more than half of all extrapulmonary cases. Pleural effusions (PEs) in TB are representative of lymphocytic PEs which are dominated by T cells.
Chen, Jianxia +14 more
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