Results 21 to 30 of about 559,282 (295)

Systematic identification of the interventional mechanism of Qingfei Xiaoyan Wan (QFXYW) in treatment of the cytokine storm in acute lung injury using transcriptomics-based system pharmacological analyses

open access: yesPharmaceutical Biology, 2022
Context Acute lung injury (ALI) is a complex, severe inflammation disease with high mortality, and there is no specific and effective treatment for ALI.
Jing-Yi Hou   +7 more
doaj   +1 more source

Sodium danshensu attenuates cerebral ischemia–reperfusion injury by targeting AKT1

open access: yesFrontiers in Pharmacology, 2022
The beneficial properties of Sodium Danshensu (SDSS) for controlling cerebral ischemia and reperfusion injury (CIRI) are elucidated here both in vivo and in vitro.
Qing Gao   +10 more
doaj   +1 more source

An Automated Approach to Assess Relative Galectin-Glycan Affinity Following Glycan Microarray Analysis

open access: yesFrontiers in Molecular Biosciences, 2022
Numerous studies have highlighted the utility of glycan microarray analysis for the elucidation of protein-glycan interactions. However, most current glycan microarray studies analyze glycan binding protein (GBP)-glycan interactions at a single protein ...
Alex D. Ho   +6 more
doaj   +1 more source

RPPanalyzer: Analysis of reverse-phase protein array data [PDF]

open access: yesBioinformatics, 2010
Abstract Summary: RPPanalyzer is a statistical tool developed to read reverse-phase protein array data, to perform the basic data analysis and to visualize the resulting biological information. The R-package provides different functions to compare protein expression levels of different samples and to normalize the data.
Mannsperger, Heiko A.   +4 more
openaire   +3 more sources

Smartphone-Based Quantitative Analysis of Protein Array Signals for Biomarker Detection in Lupus

open access: yesChemosensors, 2022
Fluorescence-based microarray offers great potential in clinical diagnostics due to its high-throughput capability, multiplex capabilities, and requirement for a minimal volume of precious clinical samples.
Guang Yang   +5 more
doaj   +1 more source

High-throughput analysis and protein engineering using microcapillary arrays [PDF]

open access: yesNature Chemical Biology, 2015
We describe a multipurpose technology platform, termed μSCALE (microcapillary single-cell analysis and laser extraction), that enables massively parallel, quantitative biochemical and biophysical measurements on millions of protein variants expressed from yeast or bacteria.
Bob Chen   +8 more
openaire   +2 more sources

Antibody Protein Array Analysis of the Tear Film Cytokines [PDF]

open access: yesOptometry and Vision Science, 2008
Many bioactive proteins including cytokines are reported to increase in dry eye disease although the specific profile and concentration of inflammatory mediators varies considerably from study to study. In part, this variability results from inherent difficulties in quantifying low abundance proteins in a limited sample volume using relatively low ...
Shimin, Li   +7 more
openaire   +2 more sources

In situ structural analysis of Golgi intracisternal protein arrays [PDF]

open access: yesProceedings of the National Academy of Sciences, 2015
Significance To our knowledge, this is the first detailed study of Golgi ultrastructure within unperturbed cells. Three intracisternal structures were identified, with implications for Golgi architecture and trafficking: ( i ) Bundles of filaments show how cargoes may ...
Engel, Benjamin D.   +5 more
openaire   +5 more sources

Pro-MAP: a robust pipeline for the pre-processing of single channel protein microarray data

open access: yesBMC Bioinformatics, 2022
Background The central role of proteins in diseases has made them increasingly attractive as therapeutic targets and indicators of cellular processes. Protein microarrays are emerging as an important means of characterising protein activity.
Metoboroghene Oluwaseyi Mowoe   +6 more
doaj   +1 more source

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