Results 241 to 250 of about 5,755,949 (365)

Cold denaturation as a tool to measure protein stability

open access: yesBiophysical Chemistry, 2016
D. Sanfelice, P. Temussi
semanticscholar   +1 more source

The cumulative analgesic effect of repeated electroacupuncture is modulated by Adora3 in the SCDH of mice with neuropathic pain

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Neuropathic pain management via repeated electroacupuncture. Abstract Background Existing remedial approaches for relieving neuropathic pain (NPP) are challenging and open the way for alternative therapeutic measures such as electroacupuncture (EA). The mechanism underlying the antinociceptive effects of repeated EA sessions, particularly concerning ...
Faisal Ayub Kiani   +6 more
wiley   +1 more source

Deficiency of DEK proto‐oncogene alleviates allergic rhinitis by inhibiting RhoA/Ezrin‐mediated mitochondrial fission

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Schematic diagram of the mechanism of DEK regulating RhoA activation Ezrin. Upon house dust mite (HDM) stimulation, HDM‐specific immunoglobulin E (IgE) and inflammatory factors such as interleukin 4 (IL‐4), IL‐5, IL‐13, and eosinophils increased in the nasal mucosa.
Longzhu Dai   +8 more
wiley   +1 more source

Establishment of rat model for aspiration pneumonia and potential mechanisms

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Aspiration pneumonia was induced in Sprague Dawley rats by intratracheal instillation of hydrochloric acid (HCl, 1.5 μL/g.wt, pH = 1) followed by lipopolysaccharide (LPS, 20 μg/g.wt) after 1 h. The model reproduced hallmark features of acute lung injury, including histological lung damage, microvascular dysfunction, inflammation, hypoxemia, and ...
Hanbing Hu   +7 more
wiley   +1 more source

Reactive Cysteines in Proteins are the Dominant Reductants for Platinum(IV) Prodrug Activation in Live Cells

open access: yesAngewandte Chemie, EarlyView.
Pt‐Luc was developed as a pioneering bioluminescent reporter for real‐time monitoring of Pt(IV) reduction in live cells. Using this advanced reporter, we identified that reactive cysteines in proteins, rather than those in small molecules, predominantly mediate the reduction of Pt(IV) prodrugs.
Shu Chen   +10 more
wiley   +2 more sources

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