Results 201 to 210 of about 42,092 (259)

Tumor‐Derived LAMB3 Drives Immunosuppressive LRRC15+ Fibroblast Formation During Pancreatic Ductal Adenocarcinoma Development

Advanced Science, EarlyView.
A single‐cell atlas of pancreatic ductal adenocarcinoma development reveals progressive ductal‐fibroblast‐immune crosstalk. Tumor‐derived LAMB3 drives the formation of immunosuppressive LRRC15+ fibroblasts through the ITGB1/FAK/MAPK/FOSL2 signaling. Glycolytic reprogramming upregulates LAMB3 and correlates with LRRC15+ fibroblast enrichment.
Xuqing Shi, Hangqi Liu, Jianru Sun, Xiaoding Liu, Xinping Jv, Longyun Chen, Yuhan Zhang, Hui Zhang, Xudong Xing, Ruiyu Li, Xinyi Ke, Jun Wang, Xianglin Yin, Bohan Liu, Qixian Liu, Yuan Wang, Junliang Lu, Shiyi Liu, Junyi Pang, Yumeng Cai, Menghua Dai, Fan Bai, Huanwen Wu, Zhiyong Liang   +23 more
wiley   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

Molecular forces driving protein complexation of lentil and whey proteins: Structure-function relationships of trehalose-conjugated protein complexes on protein digestibility and solubility. [PDF]

Curr Res Struct Biol
Alrosan M, Madi Almajwal A, Al-Qaisi A, Gammoh S, H Alu'datt M, R Al Qudsi F, Tan TC, A Razzak Mahmood A, Maghaydah S.   +8 more
europepmc   +1 more source

A novel multiple plant-based milk alternative containing various preprocessed grains achieves better performance in protein digestibility and free amino acid profile via in vitro gastrointestinal digestion analysis. [PDF]

Food Sci Nutr
Wang X, Zhang L, Wang M, Ma H, Liu S, Wang M, Yu Y, Liu G, Cao Q, Wang X, Ma X, Yuan P, Liu J, Zhang Y, Duan S.   +14 more
europepmc   +1 more source

Impact of Wooden Breast myopathy on in vitro protein digestibility, metabolomic profile, and cell cytotoxicity of cooked chicken breast meat. [PDF]

Poult Sci
Trithavisup T, Krobthong S, Yingchutrakul Y, Sanpinit P, Malila Y.   +4 more
europepmc   +1 more source

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Solution Protein Digest

Cold Spring Harbor Protocols, 2011
INTRODUCTIONThis protocol describes the trypsin digestion of proteins in solution. Proteolytic digestion is critical for mass spectrometric sequencing because it generates peptides that have molecular weights within the mass range of the mass spectrometer.
Andrew J, Link, Joshua, LaBaer
openaire   +2 more sources

Protein Digestion and Absorption

New England Journal of Medicine, 1979
ALTHOUGH protein accounts for only about 11 to 14 per cent of the total calories that Americans ingest each day, this food substance is essential for nutritional homeostasis.
Howard L. Bleich, Emily S. Boro, Marvin H. Sleisenger, Young S. Kim   +3 more
openaire   +2 more sources