Soluble Prion Protein Inhibits Amyloid-β (Aβ) Fibrillization and Toxicity [PDF]
Journal of Biological Chemistry, 2012 The pathogenesis of Alzheimer disease appears to be strongly linked to the aggregation of amyloid-β (Aβ) peptide and, especially, formation of soluble Aβ1-42 oligomers. It was recently demonstrated that the cellular prion protein, PrP(C), binds with high affinity to these oligomers, acting as a putative receptor that mediates at least some of their ...
Krzysztof, Nieznanski +4 more
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Frontiers in Physiology, 2022 Left atrial appendage (LAA) thrombus detachment resulting in intracranial embolism is a major complication of atrial fibrillation (AF). Endocardial endothelial cell (EEC) injury leads to thrombosis, whereas autophagy protects against EEC dysfunction ...
Mengjia Sun +11 more
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RhoA Activation Sensitizes Cells to Proteotoxic Stimuli by Abrogating the HSF1-Dependent Heat Shock Response. [PDF]
PLoS ONE, 2015 The heat shock response (HSR) is an ancient and highly conserved program of stress-induced gene expression, aimed at reestablishing protein homeostasis to preserve cellular fitness.
Roelien A M Meijering +10 more
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Aminoquinolones and Their Benzoquinone Dimer Hybrids as Modulators of Prion Protein Conversion
Molecules, 2022 Prion Diseases or Transmissible Spongiform Encephalopathies are neurodegenerative conditions associated with a long incubation period and progressive clinical evolution, leading to death.
Amanda Rodrigues Pinto Costa +8 more
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Insights into a Protein-Nanoparticle System by Paramagnetic Perturbation NMR Spectroscopy
Molecules, 2020 Background: The interaction between proteins and nanoparticles is a very relevant subject because of the potential applications in medicine and material science in general.
Yamanappa Hunashal +5 more
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Epigallocatechin Gallate Remodelling of Hfq Amyloid-Like Region Affects Escherichia coli Survival
Pathogens, 2018 Hfq is a pleiotropic regulator that has key roles in the control of genetic expression. The protein noticeably regulates translation efficiency and RNA decay in Gram-negative bacteria, due to the Hfq-mediated interaction between small regulatory ...
David Partouche +7 more
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N-terminal Domain of Myelin Basic Protein Inhibits Amyloid β-Protein Fibril Assembly [PDF]
Journal of Biological Chemistry, 2010 Accumulation of amyloid β-protein (Aβ) into brain parenchymal plaques and the cerebral vasculature is a pathological feature of Alzheimer disease and related disorders. Aβ peptides readily form β-sheet-containing oligomers and fibrils. Previously, we reported a strong interaction between myelin basic protein (MBP) and Aβ peptides that resulted in ...
Mei-Chen, Liao +6 more
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In Situ Characterization of Hfq Bacterial Amyloid: A Fourier-Transform Infrared Spectroscopy Study
Pathogens, 2019 Hfq is a bacterial protein that regulates gene expression at the post-transcriptional level in Gram-negative bacteria. We have previously shown that Escherichia coli Hfq protein, and more precisely its C-terminal region (CTR), self-assembles into an ...
David Partouche +5 more
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AdipoR1/APPL1 potentiates the protective effects of globular adiponectin on angiotensin II-induced cardiac hypertrophy and fibrosis in neonatal rat atrial myocytes and fibroblasts. [PDF]
PLoS ONE, 2014 Atrial hypertrophy and fibrosis are essential pathological features of atrial fibrillation. Recently, adiponectin has become a protein of interest due to its beneficial effects on cardiovascular diseases.
Tengwei Cao +7 more
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Redox Biology, 2020 Atrial fibrillation (AF) occurs in up to 11% of cancer patients treated with ibrutinib. The pathophysiology of ibrutinib promoted AF is complicated, as there are multiple interactions involved; the detailed molecular mechanisms underlying this are still ...
Xinyu Yang +12 more
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