Results 21 to 30 of about 29,093 (266)
Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles: Functional Similarities with Proteins [PDF]
Angewandte Chemie, 2011 Aggregation of amyloid-β peptides (Aβ) into fibrils is the key pathological feature of many neurodegenerative disorders. Typical drugs inhibit Aβ fibrillation by binding to monomers in 1:1 ratio and display low efficacy. Here, we report that model CdTe nanoparticles (NPs) can efficiently prevent fibrillation of Aβ associating with 100–330 monomers at ...
Yoo, Seong Il +8 more
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Frontiers in Physiology, 2020 Untreated chronic hypertension causes left ventricular hypertrophy, which is related to the occurrence of atrial fibrillation. Dronedarone is an antiarrhythmic agent recently approved for atrial fibrillation.
Laia Pazó-Sayós +3 more
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Amyloid Fibrils of Pisum sativum L. Vicilin Inhibit Pathological Aggregation of Mammalian Proteins
International Journal of Molecular Sciences, 2023 Although incurable pathologies associated with the formation of highly ordered fibrillar protein aggregates called amyloids have been known for about two centuries, functional roles of amyloids have been studied for only two decades. Recently, we identified functional amyloids in plants. These amyloids formed using garden pea Pisum sativum L.
Maksim I. Sulatsky +9 more
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Protein Disulfide Isomerase Interacts with Tau Protein and Inhibits Its Fibrillization
PLoS ONE, 2013 Tau protein is implicated in the pathogenesis of neurodegenerative disorders such as tauopathies including Alzheimer disease, and Tau fibrillization is thought to be related to neuronal toxicity. Physiological inhibitors of Tau fibrillization hold promise for developing new strategies for treatment of Alzheimer disease.
Li-Rong Xu +3 more
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Heterologous Stacking of Prion Protein Peptides Reveals Structural Details of Fibrils and Facilitates Complete Inhibition of Fibril Growth [PDF]
Journal of Biological Chemistry, 2009 Fibrils play an important role in the pathogenesis of amyloidosis; however, the underlying mechanisms of the growth process and the structural details of fibrils are poorly understood. Crucial in the fibril formation of prion proteins is the stacking of PrP monomers.
Ronald S, Boshuizen +5 more
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Curcumin Reduces Amyloid Fibrillation of Prion Protein and Decreases Reactive Oxidative Stress
Pathogens, 2013 Misfolding and aggregation into amyloids of the prion protein (PrP) is responsible for the development of fatal transmissible neurodegenerative diseases.
Raymond Chung +4 more
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Biomimetics, 2023 Surface engineering of nanoparticles has been widely used in biosensing and assays, where sensitivity was mainly limited by plasmonic colour change or electrochemical responses.
Changxin Wang +4 more
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Understanding Inhibition of Protein Amyloid Fibril Formation
, 2023 Dažniausiai pasitaikantys neurodegeneraciniai sutrikimai yra Alzheimerio ir Parkinsono ligos. Nepaisant skirtumų tarp kognityvinių simptomų, pasireiškimo vietos organizme, bei progresavimo greičio, šių ligų patologiniai požymiai yra panašūs ir siejami su baltymų agregacija į netirpius ir neuronams toksiškus darinius.
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Physiological Reports, 2022 Chronic kidney disease (CKD) is an increasing and life‐threatening disease worldwide. Recent evidence indicates that blood coagulation factors promote renal dysfunction in CKD patients.
Lixin Fang +11 more
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Biomolecules, 2019 Self-assembly of proteins to β-sheet rich amyloid fibrils is commonly observed in various neurodegenerative diseases. However, amyloid also occurs in the extracellular matrix of bacterial biofilm, which protects bacteria from environmental stress ...
Zahra Najarzadeh +11 more
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