Results 31 to 40 of about 29,093 (266)

Human lysozyme inhibits the fibrillation of serum amyloid a protein from systemic AA amyloidosis

Amyloid, 2023
Systemic AA amyloidosis is a world-wide occurring protein misfolding disease in humans and animals that arises from the formation of amyloid fibrils from serum amyloid A (SAA) protein and their deposition in multiple organs. To identify new agents that prevent fibril formation from SAA protein and to determine their mode of action. We used a cell model
Tim, Moderer, Ioana, Puşcalău-Gîrţu, Christian, Haupt, Julian, Baur, Armando, Rodríguez-Alfonso, Sebastian, Wiese, Christoph Q, Schmidt, Miroslav, Malešević, Wolf-Georg, Forssmann, Ludger, Ständker, Marcus, Fändrich   +10 more
openaire   +2 more sources

Protein Disulfide Isomerase Inhibits and Reverses Alpha‐Synuclein Fibrillization

The FASEB Journal, 2019
Protein disulfide isomerase (PDI) is a ubiquitously expressed member of the thioredoxin family with related but independent oxidoreductase and chaperone properties. As a chaperone, PDI plays a crucial role in preventing the aggregation of misfolded proteins.
Joey Ragusa, Baggio Evangelista, Albert Serrano, Xin Qiao, Yoon‐Seong Kim, Bo Chen, Ken Teter   +6 more
openaire   +1 more source

Brazilin inhibits amyloid β-protein fibrillogenesis, remodels amyloid fibrils and reduces amyloid cytotoxicity [PDF]

Scientific Reports, 2015
Soluble amyloid β-protein (Aβ) oligomers, the main neurotoxic species, are predominantly formed from monomers through a fibril-catalyzed secondary nucleation. Herein, we virtually screened an in-house library of natural compounds and discovered brazilin as a dual functional compound in both Aβ42 fibrillogenesis inhibition and mature fibril remodeling ...
Du, WJ, Guo, JJ, Gao, MT, Hu, SQ, Dong, XY, Han, YF, Liu, FF, Jiang, S, Sun, Y   +8 more
openaire   +3 more sources

Factor Xa Inhibitor Suppresses the Release of Phosphorylated HSP27 from Collagen-Stimulated Human Platelets: Inhibition of HSP27 Phosphorylation via p44/p42 MAP Kinase. [PDF]

PLoS ONE, 2016
Selective inhibitors of factor Xa (FXa) are widely recognized as useful therapeutic tools for stroke prevention in non-valvular atrial fibrillation or venous thrombosis.
Masanori Tsujimoto, Gen Kuroyanagi, Rie Matsushima-Nishiwaki, Yuko Kito, Yukiko Enomoto, Hiroki Iida, Shinji Ogura, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Toru Iwama   +10 more
doaj   +1 more source

Abnormal Calcium Handling in Atrial Fibrillation Is Linked to Changes in Cyclic AMP Dependent Signaling

Cells, 2021
Both, the decreased L-type Ca2+ current (ICa,L) density and increased spontaneous Ca2+ release from the sarcoplasmic reticulum (SR), have been associated with atrial fibrillation (AF).
Franziska Reinhardt, Kira Beneke, Nefeli Grammatica Pavlidou, Lenard Conradi, Hermann Reichenspurner, Leif Hove-Madsen, Cristina E. Molina   +6 more
doaj   +1 more source

Comparative Analysis of BTK Inhibitors and Mechanisms Underlying Adverse Effects

Frontiers in Cell and Developmental Biology, 2021
The cytoplasmic protein-tyrosine kinase BTK plays an essential role for differentiation and survival of B-lineage cells and, hence, represents a suitable drug target.
H. Yesid Estupiñán, H. Yesid Estupiñán, Anna Berglöf, Rula Zain, Rula Zain, C. I. Edvard Smith   +5 more
doaj   +1 more source

Functional and pharmacological characteristics of permeability transition in isolated human heart mitochondria.

PLoS ONE, 2013
The objective of the present study was to validate the presence and explore the characteristics of mitochondrial permeability transition (mPT) in isolated mitochondria from human heart tissue in order to investigate if previous findings in animal models ...
Saori Morota, Theodor Manolopoulos, Atli Eyjolfsson, Per-Ola Kimblad, Per Wierup, Carsten Metzsch, Sten Blomquist, Magnus J Hansson   +7 more
doaj   +1 more source

The engineered peptide construct NCAM1-Aβ inhibits fibrillization of the human prion protein (PrP)

Acta Biochimica Polonica, 2022
In prion diseases, the prion protein (PrP) becomes misfolded and forms fibrillar aggregates that are responsible for prion infectivity and pathology. So far, no drug or treatment procedures have been approved for prion disease treatment. We have previously shown that engineered cell-penetrating peptide constructs can reduce the amount of prion ...
Maciej, Gielnik, Lilia, Zhukova, Igor, Zhukov, Astrid, Gräslund, Maciej, Kozak, Sebastian, Wärmländer   +5 more
openaire   +3 more sources

Extending the functional characteristics of naturally occurring autoantibodies against β-Amyloid, Prion Protein and α-Synuclein. [PDF]

PLoS ONE, 2018
BACKGROUND:Abnormal aggregation of proteins induces neuronal cell loss in neurodegenerative disorders such as Alzheimer's Disease, Creutzfeldt-Jakob Disease and Parkinson's Disease.
Alexandra Albus, Maike Gold, Jan-Philipp Bach, Monika Burg-Roderfeld, Marit Jördens, Yvonne Kirchhein, Yannick Kronimus, David Mengel, Inga Zerr, Richard Dodel   +9 more
doaj   +1 more source

A 73‐Year‐Old Man With Several Years of Difficulty Climbing Stairs and Frequent Tripping

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT A 73‐year‐old man presented with progressive weakness and atrophy predominantly affecting the distal finger flexors and quadriceps muscles. Electrophysiological studies demonstrated mixed myogenic and neurogenic features. Muscle MRI showed inflammatory changes, and muscle biopsy revealed granulomatous myositis with histologic features ...
Mehmet Can Sari, Arens Taga, Sonya Ulrike Steele, Ahmet Hoke   +3 more
wiley   +1 more source