Motor proteins traffic regulation by supply-demand balance of resources
, 2014 In cells and in vitro assays the number of motor proteins involved in biological transport processes is far from being unlimited. The cytoskeletal binding sites are in contact with the same finite reservoir of motors (either the cytosol or the flow ...
Ciandrini, Luca +4 more
core +3 more sources
WH2 and proline-rich domains of WASP-family proteins collaborate to accelerate actin filament elongation. [PDF]
, 2017 WASP-family proteins are known to promote assembly of branched actin networks by stimulating the filament-nucleating activity of the Arp2/3 complex.
Akin, Orkun +6 more
core +1 more source
The Effects of Hsp90α1 Mutations on Myosin Thick Filament Organization. [PDF]
PLoS ONE, 2015 Heat shock protein 90α plays a key role in myosin folding and thick filament assembly in muscle cells. To assess the structure and function of Hsp90α and its potential regulation by post-translational modification, we developed a combined knockdown and ...
Qiuxia He +3 more
doaj +1 more source
Microscopic basis for pattern formation and anomalous transport in two-dimensional active gels
, 2010 Active gels are a class of biologically-relevant material containing embedded agents that spontaneously generate forces acting on a sparse filament network.
Briels, W. J. +2 more
core +1 more source
Steady-state MreB helices inside bacteria: dynamics without motors [PDF]
, 2007 Within individual bacteria, we combine force-dependent polymerization dynamics of individual MreB protofilaments with an elastic model of protofilament bundles buckled into helical configurations.
Andrew D. Rutenberg +6 more
core +2 more sources
Helical reconstruction of Salmonella and Shigella needle filaments attached to type 3 basal bodies
Biochemistry and Biophysics Reports, 2021 Gram-negative pathogens evolved a syringe-like nanomachine, termed type 3 secretion system, to deliver protein effectors into the cytoplasm of host cells.
Vadim Kotov +4 more
doaj +1 more source
Organized unidirectional waves of ATP hydrolysis within a RecA filament.
PLoS Biology, 2005 The RecA protein forms nucleoprotein filaments on DNA, and individual monomers within the filaments hydrolyze ATP. Assembly and disassembly of filaments are both unidirectional, occurring on opposite filament ends, with disassembly requiring ATP ...
Julia M Cox +2 more
doaj +1 more source
Structural basis for stabilisation of the RAD51 nucleoprotein filament by BRCA2
Nature Communications, 2023 The BRCA2 tumour suppressor protein preserves genomic integrity via interactions with the DNA-strand exchange RAD51 protein in homology-directed repair.
Robert Appleby +3 more
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Myosin II filament dynamics in actin networks revealed with interferometric scattering microscopy [PDF]
, 2020 The plasma membrane and the underlying cytoskeletal cortex constitute active platforms for a variety of cellular processes. Recent work has shown that the remodeling acto-myosin network modifies local membrane organization, but the molecular details are ...
Fineberg, A. +7 more
core +1 more source