Results 61 to 70 of about 257,652 (357)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Gelsolin-mediated actin filament severing, mechanics, and conformational changes at neutral and acidic pH

Frontiers in Soft Matter
Gelsolin is a calcium (Ca2+) dependent, pH sensitive actin-binding protein that regulates actin filament dynamics to remodel the actin cytoskeleton. It is known that gelsolin binding induces conformational changes of actin filaments, leading to filament ...
Taylor V. Douglas, Taylor V. Douglas, Claire A. Toland, Sydney A. Paulin, Nicholas Castaneda, Nicholas Castaneda, Laurene Tetard, Laurene Tetard, Ellen H. Kang, Ellen H. Kang, Ellen H. Kang   +10 more
doaj   +1 more source

Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin [PDF]

, 1998
A number of structural and functional subnuclear compartments have been described, including regions exclusive of chromosomes previously hypothesized to form a reactive nuclear space.
Bridger, JM, Herrmann, H, Lichter, P, Muenkel, C   +3 more
core  

Spire stimulates nucleation by Cappuccino and binds both ends of actin filaments. [PDF]

, 2020
The actin nucleators Spire and Cappuccino synergize to promote actin assembly, but the mechanism of their synergy is controversial. Together these proteins promote the formation of actin meshes, which are conserved structures that regulate the ...
Bailey, Hannah M, Bradley, Alexander O, Quinlan, Margot E, Vizcarra, Christina L   +3 more
core  

Rad54: the Swiss Army knife of homologous recombination? [PDF]

, 2006
Homologous recombination (HR) is a ubiquitous cellular pathway that mediates transfer of genetic information between homologous or near homologous (homeologous) DNA sequences. During meiosis it ensures proper chromosome segregation in the first division.
Heyer, Wolf-Dietrich, Li, Xuan, Rolfsmeier, Michael, Zhang, Xiao-Ping   +3 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete Leptospira

Frontiers in Cellular and Infection Microbiology, 2018
The spirochete endoflagellum is a unique motility apparatus among bacteria. Despite its critical importance for pathogenesis, the full composition of the flagellum remains to be determined. We have recently reported that FcpA is a novel flagellar protein
Elsio A. Wunder, Elsio A. Wunder, Leyla Slamti, David N. Suwondo, Kimberley H. Gibson, Zhiguo Shang, Charles V. Sindelar, Felipe Trajtenberg, Alejandro Buschiazzo, Alejandro Buschiazzo, Albert I. Ko, Albert I. Ko, Mathieu Picardeau   +12 more
doaj   +1 more source

A continuous isotropic-nematic liquid crystalline transition of F-actin solutions

, 2002
The phase transition from the isotropic (I) to nematic (N) liquid crystalline suspension of F-actin of average length $3~\mu$m or above was studied by local measurements of optical birefringence and protein concentration. Both parameters were detected to
A. Kerst, A. Suzuki, C. Coppin, F. Gittes, G.L. Vroege, J. Buitenhuis, J. Kas, J.X. Tang, J.X. Tang, Jay X. Tang, Jorge Viamontes, L. Onsager, P.E. Lammert, P.E. Lammert, R. Furukawa, R. Oldenbourg, R.E. Buxbaum, S. Chandrasekhar, S.D. Lee, T. Sato   +19 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Actin, α-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells [PDF]

, 1975
During the spreading of a population of rat embryo cells, approximately 40% of the cells develop a strikingly regular network which precedes the formation of the straight actin filament bundles seen in the fully spread out cells.
Lazarides, Elias
core   +1 more source