Results 61 to 70 of about 250,840 (309)

Gelsolin-mediated actin filament severing, mechanics, and conformational changes at neutral and acidic pH

Frontiers in Soft Matter
Gelsolin is a calcium (Ca2+) dependent, pH sensitive actin-binding protein that regulates actin filament dynamics to remodel the actin cytoskeleton. It is known that gelsolin binding induces conformational changes of actin filaments, leading to filament ...
Taylor V. Douglas, Taylor V. Douglas, Claire A. Toland, Sydney A. Paulin, Nicholas Castaneda, Nicholas Castaneda, Laurene Tetard, Laurene Tetard, Ellen H. Kang, Ellen H. Kang, Ellen H. Kang   +10 more
doaj   +1 more source

Actin, α-actinin, and tropomyosin interaction in the structural organization of actin filaments in nonmuscle cells [PDF]

, 1975
During the spreading of a population of rat embryo cells, approximately 40% of the cells develop a strikingly regular network which precedes the formation of the straight actin filament bundles seen in the fully spread out cells.
Lazarides, Elias
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

FcpB Is a Surface Filament Protein of the Endoflagellum Required for the Motility of the Spirochete Leptospira

Frontiers in Cellular and Infection Microbiology, 2018
The spirochete endoflagellum is a unique motility apparatus among bacteria. Despite its critical importance for pathogenesis, the full composition of the flagellum remains to be determined. We have recently reported that FcpA is a novel flagellar protein
Elsio A. Wunder, Elsio A. Wunder, Leyla Slamti, David N. Suwondo, Kimberley H. Gibson, Zhiguo Shang, Charles V. Sindelar, Felipe Trajtenberg, Alejandro Buschiazzo, Alejandro Buschiazzo, Albert I. Ko, Albert I. Ko, Mathieu Picardeau   +12 more
doaj   +1 more source

Identification of an interchromosomal compartment by polymerization of nuclear-targeted vimentin [PDF]

, 1998
A number of structural and functional subnuclear compartments have been described, including regions exclusive of chromosomes previously hypothesized to form a reactive nuclear space.
Bridger, JM, Herrmann, H, Lichter, P, Muenkel, C   +3 more
core  

A continuous isotropic-nematic liquid crystalline transition of F-actin solutions

, 2002
The phase transition from the isotropic (I) to nematic (N) liquid crystalline suspension of F-actin of average length $3~\mu$m or above was studied by local measurements of optical birefringence and protein concentration. Both parameters were detected to
A. Kerst, A. Suzuki, C. Coppin, F. Gittes, G.L. Vroege, J. Buitenhuis, J. Kas, J.X. Tang, J.X. Tang, Jay X. Tang, Jorge Viamontes, L. Onsager, P.E. Lammert, P.E. Lammert, R. Furukawa, R. Oldenbourg, R.E. Buxbaum, S. Chandrasekhar, S.D. Lee, T. Sato   +19 more
core   +1 more source

Spire stimulates nucleation by Cappuccino and binds both ends of actin filaments. [PDF]

, 2020
The actin nucleators Spire and Cappuccino synergize to promote actin assembly, but the mechanism of their synergy is controversial. Together these proteins promote the formation of actin meshes, which are conserved structures that regulate the ...
Bailey, Hannah M, Bradley, Alexander O, Quinlan, Margot E, Vizcarra, Christina L   +3 more
core  

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies [PDF]

, 2016
Acknowledgments This work was supported by The Croatian Science Foundation grant No. IP-2014-09-9730 (“Tau protein hyperphosphorylation, aggregation, and trans-synaptic transfer in Alzheimer’s disease: cerebrospinal fluid analysis and assessment of ...
Babić Leko, Mirjana, Bažadona, Danira, Buée, Luc, de Silva, Rohan, Delalle, Ivana, Giovanni, Giuseppe Di, Harrington, Charles, Hof, Patrick R., Jovanov-Milošević, Nataša, Wischik, Claude, Wray, Selina, Šimić, Goran   +11 more
core   +3 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source