Results 11 to 20 of about 5,231,311 (300)
The Specific Binding and Promotion Effect of Azoles on Human Aldo-Keto Reductase 7A2
Metabolites, 2023 Human AKR 7A2 broadly participates in the metabolism of a number of exogenous and endogenous compounds. Azoles are a class of clinically widely used antifungal drugs, which are usually metabolized by CYP 3A4, CYP2C19, and CYP1A1, etc. in vivo.
Wanying Wu +7 more
doaj +1 more source
Experimental and Molecular Medicine, 2018 Colorectal cancer: Potential treatment for drug-resistant cases A recently identified small molecule shows promise for tackling resistance to a leading colorectal cancer drug.
Sang-Kyu Lee +11 more
doaj +1 more source
Ion selectivity and rotor coupling of the Vibrio flagellar sodium-driven stator unit
Nature Communications, 2023 Bacteria swim using a flagellar motor that is powered by stator units. Vibrio spp. are highly motile bacteria responsible for various human diseases, the polar flagella of which are exclusively driven by sodium-dependent stator units (PomAB).
Haidai Hu +10 more
doaj +1 more source
Functional Residues in Proteins [PDF]
Journal of Amino Acids, 2011 We are delighted to present a special issue on the subject of functional residues of proteins. Finding focused articles within the time frame of a special issue is always challenging, which is further compounded by authors' reluctance in making their contributions to new journals. We have been fortunate enough that some leading researchers in the field
Ahmad, Shandar +3 more
openaire +2 more sources
Toxins, 2020 Deoxynivalenol (DON) is a highly abundant mycotoxin that exerts many adverse effects on humans and animals. Much effort has been made to control DON in the past, and bio-transformation has emerged as the most promising method.
Xiaojuan Gao +9 more
doaj +1 more source
, 2005 Background: With the increase in the number of genome sequencing projects, there is a concomitant exponential growth in the number of protein sequences whose function is still unknown.
MONTI, MARIA +3 more
core +1 more source
Functional Dynamics of Proteins [PDF]
Computational and Mathematical Methods in Medicine, 2012 X-ray crystallography captures protein conformational states that are stable enough to be captured. These observable states are simply part of the functional event in the context of protein dynamics. Life at the molecular level has a vibrant nature at physiological temperature, governed by physics laws. Molecular dynamics (MDs) simulations have been
Yang, Lee-Wei +4 more
openaire +2 more sources
WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation
Nature Communications, 2019 Overexpression of RAS proteins is frequently observed in patients with hepatocellular carcinoma. Here, the authors identify an HRAS binding protein, the E3 ubiquitin ligase WDR76, which promotes HRAS degradation, thus functioning as a tumour suppressor ...
Woo-Jeong Jeong +8 more
doaj +1 more source
Microorganisms, 2021 The GRAS (generally recognized as safe) status of Enterococcus has not yet been authenticated, but enterococci, as probiotics, have been increasingly applied in human healthcare and animal husbandry, for instance as a dietary supplement, feed additive ...
Fengru Deng +6 more
doaj +1 more source
Protein folds and functions [PDF]
Structure, 1998 The recent rapid increase in the number of available three-dimensional protein structures has further highlighted the necessity to understand the relationship between biological function and structure. Using structural classification schemes such as SCOP, CATH and DALI, it is now possible to explore global relationships between protein fold and ...
Martin, Andrew CR +8 more
openaire +2 more sources