Results 21 to 30 of about 251,250 (306)
A Yeast BiFC-seq Method for Genome-wide Interactome Mapping
Genomics, Proteomics & Bioinformatics, 2022 Genome-wide physical protein–protein interaction (PPI) mapping remains a major challenge for current technologies. Here, we reported a high-efficiency BiFC-seq method, yeast-enhanced green fluorescent protein-based bimolecular fluorescence ...
Limin Shang +11 more
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AIMS Molecular Science, 2021 Objective: The aim of the current study was to explore the gene enrichment and dysregulated pathways on the basis of interaction network analysis of SLC30A8 in type 1 diabetes mellitus (T1DM).
Afreen Bhatty +3 more
doaj +1 more source
A Rice Kinase-Protein Interaction Map [PDF]
Plant Physiology, 2008 AbstractPlants uniquely contain large numbers of protein kinases, and for the vast majority of the 1,429 kinases predicted in the rice (Oryza sativa) genome, little is known of their functions. Genetic approaches often fail to produce observable phenotypes; thus, new strategies are needed to delineate kinase function.
Ding, Xiaodong +24 more
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eLife, 2016 To improve chemical cross-linking of proteins coupled with mass spectrometry (CXMS), we developed a lysine-targeted enrichable cross-linker containing a biotin tag for affinity purification, a chemical cleavage site to separate cross-linked peptides away
Dan Tan +20 more
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Duchenne Muscular Dystrophy (DMD) Protein-Protein Interaction Mapping. [PDF]
Iran J Child Neurol, 2017 Duchenne muscular dystrophy (DMD) is one of the mortal diseases, subjected to study in terms of molecular investigation. In this study, the protein interaction map of this muscle-wasting condition was generated to gain a better knowledge of interactome profile of DMD.Applying Cytoscape and String Database, the protein-protein interaction network was ...
Rezaei Tavirani M +3 more
europepmc +3 more sources
MAP-ping Unconventional Protein-DNA Interactions [PDF]
Cell, 2009 Control of gene expression depends on a myriad of protein-DNA interactions, and the number of proteins involved just got larger. In this issue, Hu et al. (2009) identify hundreds of human proteins that bind to DNA, including many surprises such as the protein kinase ERK2 (MAPK1) that now appears to control gene expression directly.
Dioum, Elhadji M. +2 more
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Protein-protein interaction map inference using interacting domain profile pairs [PDF]
Bioinformatics, 2001 Abstract A number of predictive methods have been designed to predict protein interaction from sequence or expression data. On the experimental front, however, high-throughput proteomics technologies are starting to yield large volumes of protein-protein interaction data.
J, Wojcik, V, Schächter
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Drosophila Protein interaction Map (DPiM) [PDF]
Fly, 2012 Proteins perform essential cellular functions as part of protein complexes, often in conjunction with RNA, DNA, metabolites and other small molecules. The genome encodes thousands of proteins but not all of them are expressed in every cell type; and expressed proteins are not active at all times.
Guruharsha, K.G. +6 more
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iRefIndex: A consolidated protein interaction database with provenance
BMC Bioinformatics, 2008 Background Interaction data for a given protein may be spread across multiple databases. We set out to create a unifying index that would facilitate searching for these data and that would group together redundant interaction data while recording the ...
Magklaras George +2 more
doaj +1 more source
Mass spectrometry‐based protein–protein interaction networks for the study of human diseases
Molecular Systems Biology, 2021 A better understanding of the molecular mechanisms underlying disease is key for expediting the development of novel therapeutic interventions. Disease mechanisms are often mediated by interactions between proteins. Insights into the physical rewiring of
Alicia L Richards +2 more
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