Results 41 to 50 of about 6,367,317 (393)
Synaptic Vesicle Protein 2 (SV2) Isoforms
Asian Pacific Journal of Cancer Prevention, 2012 New molecular markers of cancer had emerged with novel applications in cancer prevention and therapeutics, including for breast cancer of unknown causes, which has a high impact on the health of women worldwide. The purpose of this research was to determine protein and mRNA expression of synaptic vesicle 2 (SV2) isoforms A, B and C in breast cancer ...
Cindy, Bandala +8 more
openaire +3 more sources
Discovering human protein diversity
Macedonian Journal of Chemistry and Chemical Engineering, 2008 Current emphasis on discovering and correlating human genetic variations lays the foundation for future studies of human protein diversity. Protein posttranslational processing, along with the translation of genetic variations, results in a complex ...
Dobrin Nedelkov
doaj +1 more source
GFAP Alternative Splicing and the Relevance for Disease – A Focus on Diffuse Gliomas
ASN Neuro, 2022 Glial fibrillary acidic protein (GFAP) is an intermediate filament protein that is characteristic for astrocytes and neural stem cells, and their malignant analogues in glioma.
Jessy V. van Asperen +2 more
doaj +1 more source
Functional Study of Carboxylesterase 1 Protein Isoforms. [PDF]
Proteomics, 2019 Abstract Carboxylesterase 1 (CES1) is a primary human hepatic hydrolase involved in hydrolytic biotransformation of numerous medications. Considerable interindividual variability in CES1 expression and activity has been consistently reported. Four isoforms of the CES1 protein are produced by alternative splicing (AS).
Wang X, Shi J, Zhu HJ.
europepmc +4 more sources
Rat Monoclonal Antibodies Specific for LST1 Proteins [PDF]
, 2009 The LST1 gene is located in the human MHC class III region and encodes transmembrane and soluble isoforms that have been suggested to play a role in the regulation of the immune response and are associated with inflammatory diseases such as rheumatoid ...
Kremmer, Elisabeth +4 more
core +1 more source
5-lipoxygenase mRNA and protein isoforms.
Basic & Clinical Pharmacology & Toxicology, 2014 Abstract5‐Lipoxygenase (5‐LO) catalyses the two initial steps in the biosynthesis of leukotrienes, a group of inflammatory lipid mediators derived from arachidonic acid. An increased level of leukotrienes is associated with chronic inflammatory diseases such as asthma or atherosclerosis.
Meike J. Ochs, B. Suess, D. Steinhilber
semanticscholar +3 more sources
PLoS ONE, 2023 Advancements in deep plasma proteomics are enabling high-resolution measurement of plasma proteoforms, which may reveal a rich source of novel biomarkers previously concealed by aggregated protein methods.
Margaret K. R. Donovan +14 more
doaj +2 more sources
A novel protein isoform of the RON tyrosine kinase receptor transforms human pancreatic duct epithelial cells. [PDF]
, 2016 The MST1R gene is overexpressed in pancreatic cancer producing elevated levels of the RON tyrosine kinase receptor protein. While mutations in MST1R are rare, alternative splice variants have been previously reported in epithelial cancers.
Babicky, M +10 more
core +5 more sources
Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo [PDF]
, 2006 The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus.
Callan, Margaret F C +5 more
core +1 more source
BMC Genomics, 2008 Background It is often the case that mammalian genes are alternatively spliced; the resulting alternate transcripts often encode protein isoforms that differ in amino acid sequences. Changes among the protein isoforms can alter the cellular properties of
Thanaraj Thangavel +2 more
doaj +1 more source