Results 11 to 20 of about 3,572,003 (397)

Protein Kinase C Family: Structures, Biological Functions, Diseases, and Pharmaceutical Interventions [PDF]

MedComm
The protein kinase C (PKC) family represents pivotal regulators in cellular signaling, whose dysregulation has been implicated in diverse human diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. PKCs transduce extracellular
Yongqi Li, Yuhan Jiang, Zhengxi Hu, Shenglan Yang, Longyin Li, Chaohu Xiong, Ya Gao, Weiguang Sun, Yonghui Zhang   +8 more
doaj   +2 more sources

Protein kinase C and endothelial dysfunction in select vascular diseases [PDF]

Frontiers in Cardiovascular Medicine
Protein kinases have crucial roles in intracellular signal transduction pathways that affect a wide range of biochemical processes, including apoptosis, metabolism, proliferation, and protein synthesis. Vascular endothelial cells are important regulators
Shawn Kant, Jun Feng
doaj   +2 more sources

c-Jun N-Terminal Kinase in Inflammation and Rheumatic Diseases. [PDF]

, 2012
The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase (MAPK) family and are activated by environmental stress. JNK is also activated by proinflammatory cytokines, such as TNF and IL-1, and Toll-like receptor ligands ...
Firestein, Gary S, Guma, Monica
core   +1 more source

Nuclear protein kinase C isoforms and apoptosis

European Journal of Histochemistry, 2009
The process of apoptosis is regulated at multiple levels through phosphorylation by several different protein kinases. The protein kinase C (PKC) family of isozymes have been shown to exert both inhibitory and stimulatory influences on apoptosis.
AM Martelli, G Mazzotti, S Capitani
doaj   +1 more source

Paired protein kinases PRKCI-RIPK2 promote pancreatic cancer growth and metastasis via enhancing NF-κB/JNK/ERK phosphorylation

Molecular Medicine, 2023
Background Protein kinases play a pivotal role in the malignant evolution of pancreatic cancer (PC) through mediating phosphorylation. Many kinase inhibitors have been developed and translated into clinical use, while the complex pathology of PC ...
Juying Jiao, Linjie Ruan, Chien-shan Cheng, Fengjiao Wang, Peiwen Yang, Zhen Chen   +5 more
doaj   +1 more source

Impact of PNKP mutations associated with microcephaly, seizures and developmental delay on enzyme activity and DNA strand break repair [PDF]

, 2012
Microcephaly with early-onset, intractable seizures and developmental delay (MCSZ) is a hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA strand break repair protein with DNA 5'-kinase and DNA 3'-phosphatase ...
Alexandra K. Walker, Beckman, Bernstein, Breslin, Breslin, Brodsky, Buck, Buck, Caldecott, Caldecott, Chappell, Christopher A. Walsh, Date, Dingwall, Dobson, Edward C. Gilmore, El-Khamisy, Evans, Garces, Hsiang, Interthal, John J. Reynolds, Karimi-Busheri, Keith W. Caldecott, Koch, Kouzminova, Kuzminov, Lee, Lindahl, Loizou, McCullough, Moreira, Riballo, Segal-Raz, Shen, Sprules, Takashima, Wang, Wang, Ward, Ward, Whitehouse   +41 more
core   +1 more source

Photoswitchable diacylglycerols enable optical control of protein kinase C. [PDF]

, 2016
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream signaling events including the translocation of C1-domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs,
A Betz, A Burgalossi, A Nadler, A Nadler, A Wuttke, AC Newton, Alexander Gottschalk, C Yang, Carsten Schultz, CI Bargmann, CJ Nolan, D Toullec, DA Jacobson, DA Jacobson, David J Hodson, DB Konrad, Dirk Trauner, Dmytro A Yushchenko, E Oancea, F Plenge-Tellechea, F Varoqueaux, FM Ashcroft, G Reither, GA Rutter, Guy A Rutter, H Fliegl, H Ishihara, J Basu, J Das, JA Frank, JA Lewis, James Allen Frank, Jatin Nagpal, JD Violin, JD Violin, JE Toettcher, Jeong-Seop Rhee, JM Herbert, JS Rhee, JT Fleming, KDB Wierda, L Coussens, M Almena, M Putyrski, MA Ravier, MA Ravier, MS Pessin, N Brose, N Brose, N Brose, Nils Brose, Noa Lipstein, P Bergsten, PA Marignani, PA Wender, PK Dadi, RJ Davis, S Brenner, S Corbalán-García, S Feng, T Hofmann, TR Mahoney, U Kikkawa, X Lou, Y Kurohane Kaneko, Y Zhao   +65 more
core   +3 more sources

TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]

, 2014
In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core   +2 more sources

Yeast Protein Kinase C

Journal of Biochemistry, 2002
The mammalian protein kinase C (PKC) superfamily plays regulatory roles in many different cellular processes. However, due to the many members that exist in cells, it is very complicated to present experimental evidence of the particular function of each member.
Pérez González, Pilar, Calonge, Teresa M.   +1 more
openaire   +3 more sources

Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognition [PDF]

, 2015
Two large phosphatidylinositol 3-kinase-related protein kinases (PIKKs), ATM and ATR, play a central role in the DNA damage response pathway. PIKKs contain a highly conserved extreme C-terminus called the FRAP-ATM-TRRAP-C-terminal (FATC) domain.
Ghosh, A., Goto, G.H., Henry, E., Ogi, H., Sugimoto, K., Zencir, Sevil   +5 more
core   +1 more source