Results 11 to 20 of about 1,262,032 (310)
Journal of Biochemistry, 2002 The mammalian protein kinase C (PKC) superfamily plays regulatory roles in many different cellular processes. However, due to the many members that exist in cells, it is very complicated to present experimental evidence of the particular function of each member.
Pérez González, Pilar +1 more
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PLoS ONE, 2021 Mitogen activated protein kinase kinase kinase (MAPKKK) form the upstream component of MAPK cascade. It is well characterized in several plants such as Arabidopsis and rice however the knowledge about MAPKKKs in tea plant is largely unknown.
Abhirup Paul +4 more
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Protein Kinase C: Targets to Regenerate Brain Injuries?
Frontiers in Cell and Developmental Biology, 2019 Acute or chronic injury to the central nervous system (CNS), causes neuronal death and irreversible cognitive deficits or sensory-motor alteration. Despite the capacity of the adult CNS to generate new neurons from neural stem cells (NSC), neuronal ...
Noelia Geribaldi-Doldán +9 more
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Protein kinase C signaling and cell cycle regulation
Frontiers in Immunology, 2013 A link between T cell proliferation and the protein kinase C (PKC) family of serine/threonine kinases has been recognized for about thirty years. However, despite the wealth of information on PKC-mediated control of T cell activation, understanding of ...
Adrian R Black, Jennifer D Black
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Mediators of Inflammation, 1993 The selective enzyme inhibitors genistein and Ro 31-8220 were used to assess the importance of protein tyrosine kinase (PTK) and protein kinase C (PKC), respectively, in N-formyl-methionyl-leucyl-phenylalanine (FMLP) induced generation of superoxide ...
K. Pollock, M. T. Withnall
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Role of Protein Kinase C in Eosinophil Function
Allergology International, 2006 Protein kinase C (PKC) isoforms are being elucidated as an increasingly diverse family of enzymes involved in the downstream signal transduction and cell function in various types of cells.
Takafumi Yamaguchi +3 more
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Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia.
PLoS ONE, 2012 Pancreatic acinar-to-ductal metaplasia (ADM) is associated with an increased risk of pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma.
Michele L Scotti +7 more
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Diacylglycerol kinase control of protein kinase C
Biochemical Journal, 2019 Abstract The diacylglycerol kinases (DGK) are lipid kinases that transform diacylglycerol (DAG) into phosphatidic acid (PA) in a reaction that terminates DAG-based signals. DGK provide negative regulation to conventional and novel protein kinase C (PKC) enzymes, limiting local DAG availability in a tissue- and subcellular-restricted ...
Isabel Mérida +3 more
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Protein Kinases as Drug Development Targets for Heart Disease Therapy
Pharmaceuticals, 2010 Protein kinases are intimately integrated in different signal transduction pathways for the regulation of cardiac function in both health and disease.
Alison L. Müller, Naranjan S. Dhalla
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Journal of Pharmacological Sciences, 2007 Angiotensin II (AII) has been reported to induce leukocyte adhesion to endothelium through up-regulation of P-selectin surface expression. However, the underlying molecular and cellular mechanisms remain unknown.
Xiaona Ge, Brad Low, Mei Liang, Jian Fu
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