Results 11 to 20 of about 1,861,293 (359)
Protein kinase C and endothelial dysfunction in select vascular diseases [PDF]
Frontiers in Cardiovascular MedicineProtein kinases have crucial roles in intracellular signal transduction pathways that affect a wide range of biochemical processes, including apoptosis, metabolism, proliferation, and protein synthesis. Vascular endothelial cells are important regulators
Shawn Kant, Jun Feng
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Protein Kinase C: Targets to Regenerate Brain Injuries? [PDF]
Frontiers in Cell and Developmental Biology, 2019 Acute or chronic injury to the central nervous system (CNS), causes neuronal death and irreversible cognitive deficits or sensory-motor alteration. Despite the capacity of the adult CNS to generate new neurons from neural stem cells (NSC), neuronal ...
Noelia Geribaldi-Doldán +9 more
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Targeting Protein Kinase C in Glioblastoma Treatment
Biomedicines, 2021 Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or 15 months after diagnosis
Noelia Geribaldi-Doldán +11 more
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The Kinase Specificity of Protein Kinase Inhibitor Peptide
Frontiers in Pharmacology, 2021 G-protein-coupled-receptor (GPCR) signaling is exquisitely controlled to achieve spatial and temporal specificity. The endogenous protein kinase inhibitor peptide (PKI) confines the spatial and temporal spread of the activity of protein kinase A (PKA ...
Yao Chen, Yao Chen, Bernardo L. Sabatini
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Protein kinase C iota regulates pancreatic acinar-to-ductal metaplasia. [PDF]
PLoS ONE, 2012 Pancreatic acinar-to-ductal metaplasia (ADM) is associated with an increased risk of pancreatic cancer and is considered a precursor of pancreatic ductal adenocarcinoma.
Michele L Scotti +7 more
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Frontiers in Pharmacology, 2021 Background: Hypertrophy of cardiomyocytes (CMs) is initially a compensatory mechanism to cardiac overload, but when prolonged, it leads to maladaptive myocardial remodeling, impairing cardiac function and causing heart failure.
Lotta Pohjolainen +4 more
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Journal of Lipid Research, 2015 Pathogenesis of insulin resistance in leptin-deficient ob/ob mice is obscure. In another form of diet-dependent obesity, high-fat-fed mice, hepatic insulin resistance involves ceramide-induced activation of atypical protein kinase C (aPKC), which ...
Mini P. Sajan +3 more
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IUBMB Life, 2000 Phosphorylation is a universal language used by cells to relay information between and within cells. One family of kinases that plays a key role in transducing information is the protein kinase C family. Members of this family interpret information from signals that result in phospholipid hydrolysis; they communicate to substrates throughout the cell ...
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BMC Cancer, 2019 Background Protein kinase C iota (PKCι) and protein kinase C zeta (PKCζ) are two atypical protein kinase (aPKC) enzymes that contribute to cell proliferation and cancer development.
Kyung-Hee Kim +7 more
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Mechanisms for redox-regulation of protein kinase C
Frontiers in Pharmacology, 2015 Protein kinase C (PKC) is comprised of a family of signal-regulated enzymes that play pleiotropic roles in the control of many physiological and pathological responses.
Susan F. Steinberg
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