SwissPalm: Protein Palmitoylation database [v1; ref status: indexed, http://f1000r.es/5co] [PDF]
F1000Research, 2015 Protein S-palmitoylation is a reversible post-translational modification that regulates many key biological processes, although the full extent and functions of protein S-palmitoylation remain largely unexplored.
Mathieu Blanc +6 more
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Protein palmitoylation in hepatic diseases: Functional insights and therapeutic strategies [PDF]
Journal of Advanced ResearchBackground: Liver pathologies represent a spectrum of conditions ranging from fatty liver to the aggressive hepatocellular carcinoma (HCC), as well as parasitic infections, which collectively pose substantial global health challenges.
Ying Wang +12 more
doaj +2 more sources
Cell Labeling with 15-YNE Is Useful for Tracking Protein Palmitoylation and Metabolic Lipid Flux in the Same Sample [PDF]
MoleculesProtein S-palmitoylation is the process by which a palmitoyl fatty acid is attached to a cysteine residue of a protein via a thioester bond. A range of methodologies are available for the detection of protein S-palmitoylation.
Nadine Merz +4 more
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Protein Palmitoylation in Leukocyte Signaling and Function [PDF]
Frontiers in Cell and Developmental Biology, 2020 Palmitoylation is a post-translational modification (PTM) based on thioester-linkage between palmitic acid and the cysteine residue of a protein. This covalent attachment of palmitate is reversibly and dynamically regulated by two opposing sets of ...
Xiaoyuan Yang +5 more
doaj +2 more sources
Exploring the role of protein palmitoylation in cancer progression and therapy: a comprehensive bibliometric study (2004–2024) [PDF]
Discover OncologyObjective This study aims to qualitatively and quantitatively assess the research landscape of palmitoylation in oncology using bibliometric analysis, thereby providing insights into research hotspots and emerging trends.
Yu Chen, Yuxuan Dai, Xing Wang, Jian Liu
doaj +2 more sources
Protein Palmitoylation Plays an Important Role in Trichomonas vaginalis Adherence. [PDF]
Mol Cell Proteomics, 2018 The flagellated protozoan parasite Trichomonas vaginalis is the etiologic agent of trichomoniasis, the most common non-viral sexually transmitted infection worldwide.
Nievas YR +6 more
europepmc +4 more sources
Post-translational palmitoylation of metabolic proteins
Frontiers in Physiology, 2023 Numerous cellular proteins are post-translationally modified by addition of a lipid group to their structure, which dynamically influences the proteome by increasing hydrophobicity of proteins often impacting protein conformation, localization, stability,
Kaitlyn M. J. H. Dennis, Lisa C. Heather
doaj +3 more sources
Palmitoylation in Renal Physiology and Pathology [PDF]
BiomoleculesPalmitoylation is a critical post-translational modification that involves the covalent binding of palmitic acid to cysteine residues within proteins.
Jingru Ma +9 more
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Protein palmitoylation: Palmitoyltransferases and their specificity. [PDF]
Exp Biol Med (Maywood), 2017 A plethora of novel information has emerged over the past decade regarding protein lipidation. The reversible attachment of palmitic acid to cysteine residues, termed S-palmitoylation, has focused a special attention. This is mainly due to the unique role of this modification in the regulation of protein trafficking and function.
Tabaczar S +4 more
europepmc +4 more sources
The Roles of Protein S-Palmitoylation in Cancers: From Dynamic Modulation to Therapeutic Potential [PDF]
Cancer CommunicationsProtein S-palmitoylation is a highly conserved posttranslational lipid modification that occurs on cysteine residues and critically influences protein maturation, subcellular localization, trafficking, and stability. Owing to its unique reversibility and
Haonan Zheng +7 more
doaj +2 more sources