Results 21 to 30 of about 30,111 (219)

S-palmitoylation and depalmitoylation at the interface of animal virus-host interactions [PDF]

Frontiers in Cellular and Infection Microbiology
Reversible protein S-palmitoylation, mediated by protein acyl transferases (PATs) and depalmitoylases, is essential for regulating numerous biological processes, including subcellular localization, protein stability, enzymatic activity, and protein ...
Rui-Qin Xu, Rui-Qin Xu, Xi-Meng Chen, Chen-Rong Wang, Shi-Jie Ma, Shi-Jie Ma, Shi-Jie Ma, Ping-Li Wang, Ping-Li Wang, Ping-Li Wang, Hong-Ying Chen, Hong-Ying Chen, Hong-Ying Chen   +12 more
doaj   +2 more sources

Crosstalk of Synapsin1 palmitoylation and phosphorylation controls the dynamicity of synaptic vesicles in neurons

Cell Death and Disease, 2022
The dynamics of synaptic vesicles (SVs) within presynaptic domains are tightly controlled by synapsin1 phosphorylation; however, the mechanism underlying the anchoring of synapsin1 with F-actin or SVs is not yet fully understood. Here, we found that Syn1
Peipei Yan, Huicong Liu, Tao Zhou, Pu Sun, Yilin Wang, Xibin Wang, Lin Zhang, Tian Wang, Jing Dong, Jiangli Zhu, Luxian Lv, Wenqiang Li, Shiqian Qi, Yinming Liang, Eryan Kong   +14 more
doaj   +1 more source

Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis

Journal of Translational Medicine, 2023
Background Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape and dynamics of protein palmitoylation in human cancers are not well
Yue Kong, Yugeng Liu, Xianzhe Li, Menglan Rao, Dawei Li, Xiaolan Ruan, Shanglin Li, Zhenyou Jiang, Qiang Zhang   +8 more
doaj   +1 more source

Palmitoylation-dependent protein sorting [PDF]

The Journal of Cell Biology, 2007
S-palmitoylation is a posttranslational modification that regulates membrane–protein interactions. However, palmitate is more than just a hydrophobic membrane anchor, as many different types of protein are palmitoylated, including transmembrane proteins. Indeed, there is now compelling evidence that palmitoylation plays a key role in regulating various
Greaves, J., Chamberlain, L.H.
openaire   +3 more sources

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

S-Palmitoylation of Synaptic Proteins in Neuronal Plasticity in Normal and Pathological Brains

Cells, 2023
Protein lipidation is a common post-translational modification of proteins that plays an important role in human physiology and pathology. One form of protein lipidation, S-palmitoylation, involves the addition of a 16-carbon fatty acid (palmitate) onto ...
Anna Buszka, Agata Pytyś, Domnic Colvin, Jakub Włodarczyk, Tomasz Wójtowicz   +4 more
doaj   +1 more source

Posttranslational Protein Palmitoylation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2007
Posttranslational modification of proteins is the foundation of intracellular signaling. Without the ability to reversibly modify proteins and lipids, cells would be unable to react to signals received from their environment. Posttranslational modification of proteins usually, but not always, occurs after a protein has arrived at the appropriate ...
Adam D. Munday, José A. López
openaire   +1 more source

Palmitoylation of Hedgehog Proteins [PDF]

, 2012
Hedgehog (Hh) proteins are secreted signaling proteins that contain amide-linked palmitate at the N-terminus and cholesterol at the C-terminus. Palmitoylation of Hh proteins is critical for effective long- and short-range signaling. The palmitoylation reaction occurs during transit of Hh through the secretory pathway, most likely in the lumen of the ER.
John A, Buglino, Marilyn D, Resh
openaire   +2 more sources

Proteomic identification of palmitoylated proteins [PDF]

Methods, 2006
A proteomic method that purifies and identifies palmitoylated proteins from complex protein extracts is described. Using the fatty acid exchange labeling chemistry (described in the preceding report), palmitoyl modifications are exchanged for biotinylated compounds, allowing the subset of palmitoyl-proteins to be affinity-purified and then identified ...
Amy F, Roth, Junmei, Wan, William N, Green, John R, Yates, Nicholas G, Davis   +4 more
openaire   +2 more sources

Protein S -palmitoylation in immunity [PDF]

Open Biology, 2021
S -palmitoylation is a reversible posttranslational lipid modification of proteins. It controls protein activity, stability, trafficking and protein–protein interactions. Recent global profiling of immune cells and targeted analysis have identified many S -palmitoylated ...
Tandrila Das, Jacob S. Yount, Howard C. Hang   +2 more
openaire   +3 more sources