Results 191 to 200 of about 618,514 (262)

Synergistic Remodeling of Tumor Immune Microenvironment via a DNA Nanodevice Integrating STING Activation and Lysosome‐Targeted PD‐L1 Degradation

Advanced Science, EarlyView.
A rational design DNA nanoplatform not only achieves efficient PD‐L1 degradation but also triggers robust STING signaling. The nanodevice effectively reprograms “cold” tumors, leading to potent inhibition of tumor growth and metastasis in vivo. ABSTRACT The cGAS‐STING pathway is a cornerstone of innate antitumor immunity; however, its therapeutic ...
Haoxiang Li, Min Hou, Shasha Sun, Jun Cao, Jian‐Hui Jiang, Jianjun He   +5 more
wiley   +1 more source

Carboxy-Methylation of the Catalytic Subunit of Protein Phosphatase 2A (PP2Ac) Integrates Methionine Availability with Methionine Addicted Cancer Cell Proliferation. [PDF]

Biomolecules
Andronicos A, Yoneda KC, Lin DW, Law FV, Bae H, Basirattalab A, Graham NA, Jang C, Kaiser P.   +8 more
europepmc   +1 more source

PhosSight: A Unified Deep Learning Framework Boosting and Accelerating Phosphoproteome Identification to Enable Biological Discoveries

Advanced Science, EarlyView.
PhosSight is a unified deep‐learning framework for phosphoproteome identification, featured by a phosphorylation‐aware detectability predictor. It improves identification sensitivity in DDA through deep re‐localization and rescoring, accelerates DIA searches by detectability‐guided spectral library pruning, and expands phosphoproteome coverage to ...
Ben Wang, Zhiyuan Cheng, Chengying She, Hongwei Zhao, Jiahui Zhang, Lin Lv, Zhihao Yan, Hongwen Zhu, Lizhuang Liu, Yan Fu, Xinpei Yi   +10 more
wiley   +1 more source

Substrate recognition principles for the PP2A-B55 protein phosphatase. [PDF]

Sci Adv
Kruse T, Garvanska DH, Varga JK, Garland W, McEwan BC, Hein JB, Weisser MB, Benavides-Puy I, Chan CB, Sotelo-Parrilla P, Mendez BL, Jeyaprakash AA, Schueler-Furman O, Jensen TH, Kettenbach AN, Nilsson J.   +15 more
europepmc   +1 more source

Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice

Advanced Science, EarlyView.
This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang, Zhengting Chen, Pengxiang Bai, Biao Liu, Lingling Meng, Jian Zhang, Xu Li, Dao‐Xiu Zhou, Xuan Ma, Yu Zhao   +9 more
wiley   +1 more source

PROTEIN PHOSPHATASE 2A B'η drives spliceosome subunit dephosphorylation to mediate alternative splicing following heat stress. [PDF]

Plant Cell
Jo SH, Park HJ, Jung H, Lee GS, Moon JH, Kim HS, Lee HJ, Jung C, Cho HS.   +8 more
europepmc   +1 more source

Protein phosphatase EYA1 regulates the dephosphorylation and turnover of BCL2L12 to promote glioma development. [PDF]

Int J Biol Sci
Wei T, Lin R, Lu Y, Jin DY, Zhang J, Sham MH.   +5 more
europepmc   +1 more source

Loss of serine/threonine protein phosphatase 6 severely impairs sexual stage development in malaria parasite Plasmodium berghei. [PDF]

PLoS Pathog
Feng Y, Gao W, Wang C, Shi S, Zhou D, Sun L, Zhu L, Cui L, Cao Y, Zhu X.   +9 more
europepmc   +1 more source

Asymmetry of centrosomes in <i>Drosophila</i> neural stem cells requires protein phosphatase 4. [PDF]

Mol Biol Cell
Segura RC, Gallaud E, Sythoff AVB, Aavula K, Taylor JA, Vahdat D, Otte F, Pielage J, Cabernard C.   +8 more
europepmc   +1 more source

Expression of Concern: Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer. [PDF]

Mol Oncol
europepmc   +1 more source