Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases [PDF]
Medicina, 2023 New disease targets and medicinal chemistry approaches are urgently needed to develop novel therapeutic strategies for treating pulmonary diseases.
Howard Yu +8 more
doaj +2 more sources
Protein Phosphatase 2A: Role in T Cells and Diseases [PDF]
Journal of Immunology Research, 2023 Protein phosphatase 2A (PP2A) is a serine–threonine phosphatase that plays an important role in the regulation of cell proliferation and signal transduction.
Suyasha Roy, Lalit Batra
doaj +2 more sources
Protein phosphatase 2A anchoring disruptor gene therapy for familial dilated cardiomyopathy [PDF]
Molecular Therapy: Methods & Clinical DevelopmentFamilial dilated cardiomyopathy is a prevalent cause of heart failure that results from the mutation of genes encoding proteins of diverse function. Despite modern therapy, dilated cardiomyopathy typically has a poor outcome and is the leading cause of ...
Xueyi Li +4 more
doaj +2 more sources
PROTEIN PHOSPHATASE 2A (PP2A) AS A THERAPEUTIC TARGET IN ACUTE MYELOID LEUKEMIA [PDF]
Frontiers in Oncology, 2016 Acute myeloid leukemia (AML) is a heterogeneous malignant disorder of hematopoietic progenitor cells in which several genetic and epigenetic aberrations have been described.
Elena eArriazu +2 more
doaj +5 more sources
Circumventing embryonic lethality with Lcmt1 deficiency: generation of hypomorphic Lcmt1 mice with reduced protein phosphatase 2A methyltransferase expression and defects in insulin signaling. [PDF]
, 2013 Protein phosphatase 2A (PP2A), the major serine/threonine phosphatase in eukaryotic cells, is a heterotrimeric protein composed of structural, catalytic, and targeting subunits.
Clarke, Steven G +3 more
core +26 more sources
Serine/Threonine Protein Phosphatase 2A Regulates the Transport of Axonal Mitochondria
Frontiers in Cellular Neuroscience, 2022 Microtubule-based transport provides mitochondria to distant regions of neurons and is essential for neuronal health. To identify compounds that increase mitochondrial motility, we screened 1,641 small-molecules in a high-throughput screening platform ...
Keunjung Heo +11 more
doaj +1 more source
PPM1A Controls Diabetic Gene Programming through Directly Dephosphorylating PPAR?? at Ser273 [PDF]
, 2020 Peroxisome proliferator-activated receptor gamma (PPAR gamma) is a master regulator of adipose tissue biology. In obesity, phosphorylation of PPAR gamma at Ser273 (pSer273) by cyclin-dependent kinase 5 (CDK5)/extracellular signal-regulated kinase (ERK ...
Choi, Jang Hyun +11 more
core +1 more source
ULK1 phosphorylation of striatin activates protein phosphatase 2A and autophagy
Cell Reports, 2021 Summary: The evolutionarily conserved ULK1 kinase complex acts as gatekeeper of canonical autophagy and regulates induction of autophagosome biogenesis.
Zehan Hu +9 more
doaj +1 more source
The Cell-Cycle Regulatory Protein p21CIP1/WAF1 Is Required for Cytolethal Distending Toxin (Cdt)-Induced Apoptosis. [PDF]
, 2020 The Aggregatibacter actinomycetemcomitans cytolethal distending toxin (Cdt) induces lymphocytes to undergo cell-cycle arrest and apoptosis; toxicity is dependent upon the active Cdt subunit, CdtB.
Boesze-Battaglia, Kathleen +4 more
core +2 more sources
Haematologica, 2013 The multiple cellular targets affected by proteasome inhibition implicate a potential role for bortezomib, a first-in-class proteasome inhibitor, in enhancing antitumor activities in hematologic malignancies.
Chun-Yu Liu +6 more
doaj +1 more source