Results 11 to 20 of about 446,560 (302)

Protein phosphatase 2A dysfunction in Alzheimer’s disease [PDF]

Frontiers in Molecular Neuroscience, 2014
Protein Phosphatase 2A (PP2A) is a large family of enzymes that account for the majority of brain Ser/Thr phosphatase activity. While PP2A enzymes collectively modulate most cellular processes, sophisticated regulatory mechanisms are ultimately ...
Jean-Marie eSontag, Estelle eSontag
doaj   +3 more sources

Bioengineered protein phosphatase 2A [PDF]

Bioengineered, 2013
Harmful algal blooms caused by phytoplankton can occur in all aquatic environments. Some of the algae present in these blooms are capable of producing extremely potent toxins. Due to climate change and eutrophication, harmful algal blooms are increasing on a global scale.
Juan A, Rubiolo, Henar, López-Alonso, Amparo, Alfonso, Félix V, Vega, Mercedes Rodríguez, Vieytes, Luis M, Botana   +5 more
openaire   +2 more sources

Hyperglycemia triggers HIPK2 protein degradation [PDF]

, 2016
Homeodomain interacting protein kinase-2 (HIPK2) is an evolutionary conserved kinase that modulates several key molecular pathways to restrain tumor growth and induce p53-depending apoptotic cell-death in response to anticancer therapies. HIPK2 silencing
Baldari, Silvia, Cirone, Mara, Cuomo, Laura, D'Orazi, Gabriella, Garufi, Alessia, Granato, Marisa, Pistritto, Giuseppa   +6 more
core   +2 more sources

Protein Phosphatase Methyl-Esterase PME-1 Protects Protein Phosphatase 2A from Ubiquitin/Proteasome Degradation.

PLoS ONE, 2015
Protein phosphatase 2A (PP2A) is a conserved essential enzyme that is implicated as a tumor suppressor based on its central role in phosphorylation-dependent signaling pathways.
Ryotaro Yabe, Akane Miura, Tatsuya Usui, Ingrid Mudrak, Egon Ogris, Takashi Ohama, Koichi Sato   +6 more
doaj   +1 more source

Protein phosphatase beta, a putative type-2A protein phosphatase from the human malaria parasite Plasmodium falciparum. [PDF]

, 1997
Protein phosphatases play a critical role in the regulation of the eukaryotic cell cycle and signal transduction. A putative protein serine/threonine phosphatase gene has been isolated from the human malaria parasite Plasmodium falciparum.
Arndt K. T., Barton G. J., Bruce M. C., Chen J., Chen J., Day K. P., Favre B., Kamibayashi C., Kennelly P. I., Lee J., Li I. L., Lin F. C., Lorca T., Nussenzweig R. S., Pallas D. C., Posas F., Rangachari K., Read L. K., Ronne H., Ross-MacDonald P. B., Shima H., Snaith H. A., Sneddon A. A., Stone S. R., Sutton A., Wera S., Xie H., Zhang Z., Zhang Z., Zhao Y., Zhao Y., Zhuo S., Zolnierowicz S.   +32 more
core   +1 more source

The structural requirements for ceramide activation of serine-threonine protein phosphatases

Journal of Lipid Research, 2004
The protein phosphatases1 (PP1) and 2A (PP2A) serve as ceramide-activated protein phosphatases (CAPP). In this study, the structural requirements for interaction between ceramide and CAPP were determined.
Charles E. Chalfant, Zdzislaw Szulc, Patrick Roddy, Alicja Bielawska, Yusuf A. Hannun   +4 more
doaj   +1 more source

MicroRNA exporter HuR clears the internalized pathogens by promoting pro‐inflammatory response in infected macrophages

EMBO Molecular Medicine, 2020
HuR is a miRNA derepressor protein that can act as miRNA sponge for specific miRNAs to negate their action on target mRNAs. Here we have identified how HuR, by inducing extracellular vesicles‐mediated export of miRNAs, ensures robust derepression of ...
Avijit Goswami, Kamalika Mukherjee, Anup Mazumder, Satarupa Ganguly, Ishita Mukherjee, Saikat Chakrabarti, Syamal Roy, Shyam Sundar, Krishnananda Chattopadhyay, Suvendra N Bhattacharyya   +9 more
doaj   +1 more source

Novel prokaryotic expression of thioredoxin-fused insulinoma associated protein tyrosine phosphatase 2 (IA-2), its characterization and immunodiagnostic application [PDF]

, 2016
Background The insulinoma associated protein tyrosine phosphatase 2 (IA-2) is one of the immunodominant autoantigens involved in the autoimmune attack to the beta-cell in Type 1 Diabetes Mellitus.
A Trabucchi, A Trabucchi, A Trabucchi, A Villalba, A Villalba, A Westerlund-Karlsson, Adriana Victoria Sabljic, AG Krochik, AL Notkins, Aldana Trabucchi, BD Spangler, Bruno David Rovitto, C Levy-Marchal, C Tiberti, C Torn, CA Baer, CC Richardson, CF Verge, D Barford, DU Rabin, DU Rabin, E Bonifacio, E Bonifacio, E Kawasaki, EA Gale, Edgardo Poskus, ELD Harlow, ER LaVallie, ER LaVallie, ET Mambetisaeva, Expert Committee on the Diagnosis and Classification of Diabetes Mellitus, F Baneyx, F Sodoyez-Goffaux, G Hannig, GS Eisenbarth, H Goetz, H Mziaut, H Mziaut, H Shägger, H Xie, I Kikkas, J Sambrook, J Seissler, J Suckale, JA Berzofsky, JA Berzofsky, JA Dromey, JC Sodoyez, JM Gonzalez-Buitrago, JM Wenzlau, JP Palmer, K Lobner, KT Elvers, L Castano, LL Guerra, Luciano Lucas Guerra, M Hawa, M Knip, M Masuda, M Solimena, M Trajkovski, M Trajkovski, MA Payton, ML Papouchado, ML Papouchado, MP Sica, MS Lan, MS Lan, Natalia Inés Faccinetti, NG Morgenthaler, O Pines, P Tompa, PD Burbelo, PJ Bingley, PZ Zimmet, R Gianani, R Turner, RD Hoffman, RR Stumpo, Ruben Francisco Iacono, S Chen, S Krause, S Schubert, S Torii, Silvina Noemí Valdez, SJ Kim, SLBP Thrower, SN Valdez, SN Valdez, T Ort, T Tuomi, VN Uversky, WA Hagopian, X Jia, X Palomer, Z Zhao   +95 more
core   +5 more sources

Memantine Attenuates Alzheimer's Disease-Like Pathology and Cognitive Impairment.

PLoS ONE, 2015
Deficiency of protein phosphatase-2A is a key event in Alzheimer's disease. An endogenous inhibitor of protein phosphatase-2A, inhibitor-1, I1PP2A, which inhibits the phosphatase activity by interacting with its catalytic subunit protein phosphatase-2Ac,
Xiaochuan Wang, Julie Blanchard, Inge Grundke-Iqbal, Khalid Iqbal   +3 more
doaj   +1 more source

Autoregulation of Protein Phosphatase Type 2A Expression [PDF]

Journal of Biological Chemistry, 1998
Protein phosphatases are involved in many cellular processes. One of the most abundant of these enzymes, the serine/threonine-specific protein phosphatase type 2A (PP2A), is present in most eukaryotic cells and serves a variety of functions. However, the detailed study of its regulation and function has been hampered by the difficulty of manipulating ...
Z, Baharians, A H, Schönthal
openaire   +2 more sources