Marine Longilenes, Oxasqualenoids with Ser-Thr Protein Phosphatase 2A Inhibition Activity
Marine Drugs, 2018 The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide (1), longilene (2), and (+)-prelongilene (3) that were ...
Francisco Cen-Pacheco +5 more
doaj +1 more source
Protein phosphatase 2A is a specific protamine-kinase-inactivating phosphatase [PDF]
Biochemical Journal, 1992 Purified preparations of a protamine protein kinase from bovine kidney cytosol [Damuni, Amick & Sneed (1989) J. Biol. Chem. 264, 6412-6416] were inactivated after incubation with near-homogeneous preparations of protein phosphatase 2A1 and protein phosphatase 2A2.
G D, Amick, S A, Reddy, Z, Damuni
openaire +2 more sources
FEBS Open Bio, 2018 Reversible methyl‐esterification (methylation) of Leu309 in the protein phosphatase 2A catalytic subunit (PP2Ac) is essential for proper biogenesis of the PP2A holoenzyme.
Ryotaro Yabe +6 more
doaj +1 more source
Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A
Neurobiology of Disease, 2008 The down-regulation of protein phosphatase 2A (PP2A) activity is thought to play an important role in the formation of tau hyperphosphorylation in the Alzheimer's disease (AD) brain. Methylation of the PP2A catalytic subunit at the L309 site can potently
Xin-Wen Zhou +6 more
doaj +1 more source
Protein interactome of the Cancerous Inhibitor of protein phosphatase 2A (CIP2A) in Th17 cells
Current Research in Immunology, 2020 Cancerous inhibitor of protein phosphatase 2A (CIP2A) is involved in immune response, cancer progression, and Alzheimer's disease. However, an understanding of the mechanistic basis of its function in this wide spectrum of physiological and pathological ...
Mohd Moin Khan +11 more
doaj +1 more source
Free Fatty Acids Inhibit Protein Tyrosine Phosphatase 1B and Activate Akt
Cellular Physiology and Biochemistry, 2013 Background/Aims: Accumulating evidence has suggested that free fatty acids (FFAs) interact with protein kinases and protein phosphatases. The present study examined the effect of FFAs on protein phosphatases and Akt.
Eisuke Shibata +6 more
doaj +1 more source
Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation [PDF]
, 2020 Embryonic Stem Cell (ESC) differentiation requires complex cell signalling network dynamics, although the key molecular events remain poorly understood.
Budzyk, Manon +10 more
core +2 more sources
Generation of active protein phosphatase 2A is coupled to holoenzyme assembly. [PDF]
PLoS Biology, 2007 Protein phosphatase 2A (PP2A) is a prime example of the multisubunit architecture of protein serine/threonine phosphatases. Until substrate-specific PP2A holoenzymes assemble, a constitutively active, but nonspecific, catalytic C subunit would constitute
Hans Hombauer +6 more
doaj +1 more source
Therapeutic reactivation of protein phosphatase 2A in acute myeloid leukemia
Frontiers in Oncology, 2015 Protein phosphatase 2A (PP2A) is a serine/threonine phosphatase that is required for normal cell growth and development. PP2A is a potent tumor suppressor, which is inactivated in cancer cells as a result of genetic deletions and mutations.
Kavitha eRamaswamy +2 more
doaj +1 more source
Phosphorylation Promotes the Accumulation of PERIOD Protein Foci
Research, 2023 Circadian clock drives the 24-h rhythm in our behavior and physiology. The molecular clock consists of a series of transcriptional/translational feedback loops operated by a number of clock genes.
Mengna Li, Shujing Li, Luoying Zhang
doaj +1 more source