Uncovering protein prenylation in Th1 cells: novel prenylation sites and insights into statin and farnesyltransferase inhibition [PDF]
BMC BiologyBackground T helper 1 (Th1) cell activation is an essential process for immune responses and is tightly regulated, including the prenylation of proteins critical for T cell function.
Jana Koch +9 more
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Chloroplastic protein prenylation: an internal or external affair? Reconciling biochemical data through a new hypothesis [PDF]
Frontiers in Plant ScienceProtein prenylation facilitates membrane association, protein interactions, and trafficking by attaching isoprenoid groups to C-terminal cysteine residues in the cytosol, with subsequent proteolysis and carboxymethylation occurring in the endoplasmic ...
Manfei Luo, Wei Chi
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Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions [PDF]
Nature Communications, 2019 Macrophage specific deletion of GGTase-I, a prenylation enzyme, in mice induces inflammatory response and rheumatoid arthritis. Here the authors show that GGTase-I deficiency and the resulting reduction of RAC1 prenylation increase RAC1 interaction with ...
Murali K. Akula +13 more
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Protein prenylation in spinach chloroplasts [PDF]
Proceedings of the National Academy of Sciences, 1999 Protein prenylation in plants was studied by in vivo metabolic 3 H-mevalonate labeling in combination with a range of protein synthesis inhibitors.
I, Parmryd, B, Andersson, G, Dallner
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Protein Prenylation and Hsp40 in Thermotolerance of Plasmodium falciparum Malaria Parasites [PDF]
mBio, 2021 During its complex life cycle, the malaria parasite survives dramatic environmental stresses, including large temperature shifts.
Emily S. Mathews +2 more
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Updates on protein-prenylation and associated inherited retinopathies [PDF]
Frontiers in OphthalmologyMembrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids ...
Sudhat Ashok +3 more
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Inhibition of Protein Prenylation of GTPases Alters Endothelial Barrier Function [PDF]
Int J Mol Sci, 2019 The members of Rho family of GTPases, RhoA and Rac1 regulate endothelial cytoskeleton dynamics and hence barrier integrity. The spatial activities of these GTPases are regulated by post-translational prenylation. In the present study, we investigated the
Christian Troidl +5 more
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Targeting Protein Prenylation in Progeria [PDF]
Science Translational Medicine, 2013 Results of a recent clinical trial in children with Hutchinson-Gilford progeria spur scientists to consider new therapeutic strategies.
Stephen G, Young +4 more
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Towards the systematic mapping and engineering of the protein prenylation machinery in Saccharomyces cerevisiae. [PDF]
PLoS ONE, 2015 Protein prenylation is a widespread and highly conserved eukaryotic post-translational modification that endows proteins with the ability to reversibly attach to intracellular membranes.
Viktor Stein +4 more
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Defective Protein Prenylation in a Spectrum of Patients With Mevalonate Kinase Deficiency [PDF]
Frontiers in Immunology, 2019 The rare autoinflammatory disease mevalonate kinase deficiency (MKD, which includes HIDS and mevalonic aciduria) is caused by recessive, pathogenic variants in the MVK gene encoding mevalonate kinase.
Marcia A. Munoz +10 more
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