Deciphering protein prenylation in endocytic trafficking in Toxoplasma gondii [PDF]
mBioToxoplasma gondii is a widespread intracellular protozoan pathogen infecting virtually all warm-blooded animals. This parasite acquires host-derived resources to support its replication inside a membrane-bound parasitophorous vacuole within infected host
Vern B. Carruthers, Zhicheng Dou
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Impact of protein prenylation inhibition on Mycobacterium leprae viability and IL-1β production in infected macrophages [PDF]
Journal of BacteriologyLeprosy is a chronic infectious disease caused by Mycobacterium leprae and M. lepromatosis. Brazil consistently ranks among the countries with the highest number of leprosy cases. Data from our group showed that M.
Matheus da Silva Rocha +11 more
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The role of protein prenylation inhibition through targeting FPPS by zoledronic acid in the prevention of renal fibrosis in rats [PDF]
Scientific ReportsRenal fibrosis (RF) represents the most widespread pathological condition in chronic kidney disease (CKD). Recently, protein prenylation has been implicated in the fibrosis’s progression. The research examined the renoprotective effect of zoledronic acid
Reham Hussein Mohamed +7 more
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CpG Methylation of Protein Prenyltransferase Genes FNTA, FNTB, PGGT1B and RABGGTA in Cancer Cell Lines [PDF]
EpigenomesBackground: Protein prenylation is crucial for the function of hundreds of proteins. Aberrant protein prenylation can be caused by the aberrant expression of prenyltransferases (PTases), which has been reported for multiple cancer entities.
Dominik Jung +3 more
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Case Report: Clinical application of an in vitro prenylation assay in the diagnosis of an early-onset case of mevalonate kinase deficiency harbouring a novel MVK variant [PDF]
Frontiers in PediatricsMevalonate kinase deficiency (MKD) is a systemic autoinflammatory disease caused by biallelic mutations in MVK. Individuals with MKD present with a recurrent fever syndrome, often including a skin rash, gastrointestinal symptoms and lymphadenopathy.
Alice Burleigh +12 more
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Biochemistry of protein prenylation.
Journal of Lipid Research, 1992 Covalent modification by isoprenoid lipids (prenylation) is now recognized as a mechanism to promote membrane interactions and biological activities of a variety of cellular proteins. Both the 15-carbon farnesyl and 20-carbon geranylgeranyl isoprenoids are involved in these modifications, which occur on carboxyl-terminal cysteine residues of proteins ...
PJ Casey
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Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2018 Angela Jeong +2 more
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Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease [PDF]
Molecular Neurobiology, 2014 Ling Li
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Chloroplastic prenylated proteins [PDF]
FEBS Letters, 1997 By in vivo [3H]mevalonate labelling of spinach combined with biochemical analysis, evidence is provided for the existence of protein prenylation in chloroplasts. Approximately 20 prenylated polypeptides were resolved by SDS‐PAGE followed by autoradiography.
Parmryd, Ingela +4 more
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Targeting protein prenylation in progeria. [PDF]
Sci Transl Med, 2013 Results of a recent clinical trial in children with Hutchinson-Gilford progeria spur scientists to consider new therapeutic strategies.
Young SG +4 more
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