Results 21 to 30 of about 3,381,535 (185)

Increased core body temperature exacerbates defective protein prenylation in mouse models of mevalonate kinase deficiency [PDF]

The Journal of Clinical Investigation, 2022
Mevalonate kinase deficiency (MKD) is characterized by recurrent fevers and flares of systemic inflammation, caused by biallelic loss-of-function mutations in MVK.
Marcia A. Munoz, Oliver P. Skinner, Etienne Masle-Farquhar, Julie Jurczyluk, Ya Xiao, Emma K. Fletcher, Esther Kristianto, Mark P. Hodson, Seán I. O’Donoghue, Sandeep Kaur, Robert Brink, David G. Zahra, Elissa K. Deenick, Kristen A. Perry, Avril A.B. Robertson, Sam Mehr, Pravin Hissaria, Catharina M. Mulders-Manders, Anna Simon, Michael J. Rogers   +19 more
doaj   +2 more sources

Deciphering protein prenylation in endocytic trafficking in Toxoplasma gondii [PDF]

mBio
Toxoplasma gondii is a widespread intracellular protozoan pathogen infecting virtually all warm-blooded animals. This parasite acquires host-derived resources to support its replication inside a membrane-bound parasitophorous vacuole within infected host
Vern B. Carruthers, Zhicheng Dou
doaj   +2 more sources

Impact of protein prenylation inhibition on Mycobacterium leprae viability and IL-1β production in infected macrophages [PDF]

Journal of Bacteriology
Leprosy is a chronic infectious disease caused by Mycobacterium leprae and M. lepromatosis. Brazil consistently ranks among the countries with the highest number of leprosy cases. Data from our group showed that M.
Matheus da Silva Rocha, Antônio Marcos Rodrigues Pereira, Plínio Marcos Freire dos Santos, André Alves Dias, Melissa Pontes Pereira, Patrícia Sammarco Rosa, Daniele F. F. Bertoluci, John T. Belisle, Fabricio da Mota Ramalho Costa, Cristiana Santos de Macedo, Maria Cristina Vidal Pessolani, Marcia Berrêdo-Pinho   +11 more
doaj   +2 more sources

The role of protein prenylation inhibition through targeting FPPS by zoledronic acid in the prevention of renal fibrosis in rats [PDF]

Scientific Reports
Renal fibrosis (RF) represents the most widespread pathological condition in chronic kidney disease (CKD). Recently, protein prenylation has been implicated in the fibrosis’s progression. The research examined the renoprotective effect of zoledronic acid
Reham Hussein Mohamed, Dina S. Abdelrahim, Nesma Hussein Abdel Hay, Nesma Mohamed Fawzy, Doaa Karem M. M., Dalia Ahmed Yousef Yehia, Omnia M. AbdelMaksoud, Yomna M. Tamim   +7 more
doaj   +2 more sources

Protein farnesylation: from molecular mechanisms to therapeutic targeting in cancer, aging, and beyond [PDF]

Frontiers in Pharmacology
Protein farnesylation, catalyzed by farnesyltransferase (FTase), covalently attaches a 15-carbon farnesyl lipid to cysteine residues within C-terminal CaaX motifs.
Jiacheng Lou, Danlu Zhang, Yingjie Wang, Yingjie Wang   +3 more
doaj   +2 more sources

Protein Prenylation in the moss Physcomitrium patens [PDF]

, 2021
Protein prenylation is the addition of a 15 or 20 carbon lipid to a cysteine near carboxyl terminus of target proteins. Prenylation increases hydrophobicity, which facilitates membrane associations and protein-protein interaction.
Running, Mark P., Ahmed, Anam F., Qaissi, Zayna H., Running, Mark P, Qaissi, Zayna, Brown, Katherine Vo., Brown, Katherine V   +6 more
core   +2 more sources

The prenylated pUS2 protein of pseudorabies virus contributes to phosphorylation of connexin 43 and suppression of gap junctional intercellular communication [PDF]

Journal of Virology
Gap junctional intercellular communication (GJIC) enables the direct transfer of signaling molecules between neighboring cells and plays an important role in innate antiviral immunity by facilitating bystander defense responses. We previously showed that
Alexander Tishchenko, Benjamin De Boeck, Cliff Van Waesberghe, Fien van Raemdonck, Walter Fuchs, Barbara G. Klupp, Thomas C. Mettenleiter, Oliver Vickman, Gregory A. Smith, Herman W. Favoreel   +9 more
doaj   +2 more sources

Investigating the Regulation of Ras Protein Prenylation [PDF]

, 2019
Ras family small GTPases undergo prenylation for proper localization to the plasma membrane, where they carry out their signaling function. Prevalent mutations in these proteins that render them persistently active have attracted a lot of attention due ...
Garcia-Torres, Desiree
core   +7 more sources

Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters.

PLoS ONE, 2022
Protein prenylation by farnesyltransferase (FTase) is often described as the targeting of a cysteine-containing motif (CaaX) that is enriched for aliphatic amino acids at the a1 and a2 positions, while quite flexible at the X position.
Brittany M Berger, Wayland Yeung, Arnav Goyal, Zhongliang Zhou, Emily R Hildebrandt, Natarajan Kannan, Walter K Schmidt   +6 more
doaj   +1 more source

Cloning and Characterization of Protein Prenyltransferase Alpha Subunit in Rice

Rice Science, 2021
Protein prenylation plays a crucial role in plant development and stress response. We report the function of prenyltransferase α-subunit in rice. Protein-protein interactions showed that the farnesyl- transferase (OsPFT)/geranylgeranyltransferase-I ...
Wang Tao, Lou Lijuan, Li Zeyu, Shang Lianguang, Wang Quan   +4 more
doaj   +1 more source