Results 21 to 30 of about 40,533 (205)
Chloroplastic prenylated proteins [PDF]
FEBS Letters, 1997 By in vivo [3H]mevalonate labelling of spinach combined with biochemical analysis, evidence is provided for the existence of protein prenylation in chloroplasts. Approximately 20 prenylated polypeptides were resolved by SDS‐PAGE followed by autoradiography.
Parmryd, Ingela +4 more
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Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease. [PDF]
Crit Rev Biochem Mol Biol, 2018 Jeong A +4 more
europepmc +2 more sources
Single prenyl-binding site on protein prenyl transferases [PDF]
Proceedings of the National Academy of Sciences, 1998 Three distinct protein prenyl transferases, one protein farnesyl transferase (FTase) and two protein geranylgeranyl transferases (GGTase), catalyze prenylation of many cellular proteins. One group of protein substrates contains a C-terminal C AAX motif (C is Cys, A is aliphatic, and
L, Desnoyers, M C, Seabra
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Specific Disruption of Ras2 CAAX Proteolysis Alters Its Localization and Function
Microbiology Spectrum, 2023 Many CAAX proteins, such as Ras GTPase, undergo a series of posttranslational modifications at their carboxyl terminus (i.e., cysteine prenylation, endoproteolysis of AAX, and carboxylmethylation).
Rajani Ravishankar +6 more
doaj +1 more source
PLoS Biology, 2023 The prenylated form of the human 2'-5'-oligoadenylate synthetase 1 (OAS1) protein has been shown to potently inhibit the replication of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the virus responsible for the Coronavirus Disease 2019 ...
Spyros Lytras +11 more
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PLoS ONE, 2022 Protein prenylation by farnesyltransferase (FTase) is often described as the targeting of a cysteine-containing motif (CaaX) that is enriched for aliphatic amino acids at the a1 and a2 positions, while quite flexible at the X position.
Brittany M Berger +6 more
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Cloning and Characterization of Protein Prenyltransferase Alpha Subunit in Rice
Rice Science, 2021 Protein prenylation plays a crucial role in plant development and stress response. We report the function of prenyltransferase α-subunit in rice. Protein-protein interactions showed that the farnesyl- transferase (OsPFT)/geranylgeranyltransferase-I ...
Wang Tao +4 more
doaj +1 more source
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. [PDF]
PLoS ONE, 2012 Statins such as simvastatin are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and standard therapy for the prevention and treatment of cardiovascular diseases in mammals.
Stephen R Spindler +9 more
doaj +1 more source
Protein prenylation in spinach chloroplasts [PDF]
Proceedings of the National Academy of Sciences, 1999 Protein prenylation in plants was studied by in vivo metabolic 3 H-mevalonate labeling in combination with a range of protein synthesis inhibitors. In spinach cotyledons, this posttranslational protein modification was found to be divided into two categories, one representing the conventional
I, Parmryd, B, Andersson, G, Dallner
openaire +2 more sources
Significance of KRAS/PAK1/Crk pathway in non-small cell lung cancer oncogenesis. [PDF]
, 2015 BackgroundKey effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).MethodsWe used NSCLC ...
Aljilani, Amir +7 more
core +2 more sources