Results 41 to 50 of about 3,381,535 (185)
Angewandte Chemie, EarlyView.A modular farnesyltransferase‐based chemoenzymatic platform enables fast, site‐specific labeling of nanobodies for PET imaging of inflammation. CD11b‐targeted PET agents selectively image myeloid‐driven inflammation, while CD45‐targeted PET agents provide sensitive whole‐body immune mapping.
Sneha Venkatachalapathy +7 more
wiley +2 more sources
Structure, regulation and cellular functions of Rab geranylgeranyl transferase and its cellular partner Rab Escort Protein [PDF]
, 2012 Rab geranylgeranyl transferase is an enzyme responsible for double geranylgeranylation of Rab proteins in all eukaryotic cells. In the present article we would like to focus on new findings concerning the holoenzyme structure and mechanism of catalytic ...
Swiezewska, Ewa, Gutkowska, Malgorzata
core +1 more source
, 2021 Protein prenylation is an important post-translational modification that regulates protein interactions, localizations, and signaling pathways in normal functioning of eukaryotic cells.
Saiful M. Chowdhury (1654066) +1 more
core +1 more source
Amyloid-beta Causes Autophagy Dysfunction by Inhibiting Protein Prenylation [PDF]
, 2016 There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear.
Smith, Kevan Thomas
core +1 more source
Combinatorial Modulation of Protein Prenylation [PDF]
ACS Chemical Biology, 2007 The cell has >60 different farnesylated proteins. Many critically important signal transduction proteins are post-translationally modified with attachment of a farnesyl isoprenoid catalyzed by protein farnesyltransferase (FTase). Recently, it has been shown that farnesyl diphosphate (FPP) analogues can alter the peptide substrate specificity of FTase ...
Amanda J, Krzysiak +7 more
openaire +2 more sources
Protein farnesyltransferase and protein prenylation in Plasmodium falciparum [PDF]
, 2002 Comparison of the malaria parasite and mammalian protein prenyltransferases and their cellular substrates is important for establishing this enzyme as a target for developing antimalarial agents.
Patel, Hetal +6 more
core +1 more source
Scientific Reports, 2021 Protein prenylation involves the attachment of one or two isoprenoid group(s) onto cysteine residues positioned near the C-terminus. This modification is essential for many signal transduction processes.
Kiall F. Suazo +6 more
doaj +1 more source
Protein prenylation in Schizosaccharomyces pombe [PDF]
FEBS Letters, 1992 S. pombe is shown to be a powerful system for studies concerning attachment or polyisoprenoid moieties to proteins, due to its ability to take up exogenous mevalonic acid efficiently. The fission yeast can take up about 5% of the exogenously added mevalonic acid and incorporate ∼10% of this into protein.
Giannakouros, Thomas +2 more
openaire +2 more sources
Studying protein-protein interactions using peptide arrays [PDF]
, 2010 Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T. +7 more
core +1 more source
mBio, 2023 In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process at the micropore/cytostome in these parasites.
Qiang-Qiang Wang +16 more
doaj +1 more source