Results 41 to 50 of about 40,533 (205)

Multiple domain insertions and losses in the evolution of the Rab prenylation complex

BMC Evolutionary Biology, 2007
Background Rab proteins are regulators of vesicular trafficking, requiring a lipid modification for proper function, prenylation of C-terminal cysteines.
Pereira-Leal Jose B, Rasteiro Rita
doaj   +1 more source

Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure

Platelets, 2023
Statins inhibit the mevalonate pathway by impairing protein prenylation via depletion of lipid geranylgeranyl diphosphate (GGPP). Rab27b and Rap1a are small GTPase proteins involved in dense granule secretion, platelet activation, and regulation.
Mohammed M Jalal, Claire S Whyte, Fraser P Coxon, Nicola J Mutch   +3 more
doaj   +1 more source

Site of Prenylation Reaction in Synthesis of Phylloquinone (Vitamin K1) by Spinach Chloroplasts [PDF]

, 1981
In spinach chloroplasts, 1,4-dihydroxy-2-naphthoate is prenylated by phytyldiphosphate and subsequently methylated by S-adenosylmethionine to form phylloquinol.
Baldwin, Block, Bryant, Dialameh, Douce, Haas, Hutson, Jensen, Joo, Lee, Lichtenthaler, Lichtenthaler, Martius, Mayer, Rüdiger, Shineberg, Soil, Soll, Soll, Suttie, Thomas, Young, Zenk   +22 more
core   +1 more source

Flip-Flopping Retinal in Microbial Rhodopsins as a Template for a Farnesyl/Prenyl Flip-Flop Model in Eukaryote GPCRs

Frontiers in Neuroscience, 2019
Thirty years after the first description and modeling of G protein coupled receptors (GPCRs), information about their mode of action is still limited. One of the questions that is hard to answer is: how do the allosteric changes in the GPCR induced by, e.
Arnold De Loof, Liliane Schoofs
doaj   +1 more source

Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53

Frontiers in Oncology, 2020
Missense mutations in the TP53 gene are among the most frequent alterations in human cancer. Consequently, many tumors show high expression of p53 point mutants, which may acquire novel activities that contribute to develop aggressive tumors.
Carla M Borini Etichetti, Evelyn Arel Zalazar, Nabila Cocordano, Javier Girardini   +3 more
doaj   +1 more source

Towards complete sets of farnesylated and geranylgeranylated proteins. [PDF]

PLoS Computational Biology, 2007
Three different prenyltransferases attach isoprenyl anchors to C-terminal motifs in substrate proteins. These lipid anchors serve for membrane attachment or protein-protein interactions in many pathways.
Sebastian Maurer-Stroh, Manfred Koranda, Wolfgang Benetka, Georg Schneider, Fernanda L Sirota, Frank Eisenhaber   +5 more
doaj   +1 more source

Biosynthesis of α-Tocopherol and Plastoquinone-9 in spinach chloroplasts [PDF]

, 1980
Prenylation and methylation reaction in al biosynthesis is localized in the envelope membranes of the chloroplasts, while PQ-9 biosynthesis takes place in the envelope membranes and also in the thylakoid membranes.
Mazliak, P., Schultz, Gernot, Soll, Jürgen   +2 more
core   +1 more source

Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra) [PDF]

, 2011
The roots of licorice (Glycyrrhiza glabra) are a rich source of flavonoids, in particular, prenylated flavonoids, such as the isoflavan glabridin and the isoflavene glabrene.
Bovee, T.F.H., Gruppen, H., Luijendijk, T.J.C., Mol, L.A.M., Simons, R., The, S.A.M., Verbruggen, M.A., Vincken, J.P.   +7 more
core   +2 more sources

Bisphosphonate inhibits the expression of cyclin A2 at the transcriptional level in normal human oral keratinocytes. [PDF]

, 2017
Nitrogen-containing bisphosphonates (N-BPs) are the most widely used anti-resorptive agents in the treatment of bone-related diseases. N-BPs inhibit bone resorption by specifically targeting osteoclasts, bone-resorbing cells.
Kang, Mo K, Kim, Reuben H, Lee, Rachel S, Park, No-Hee, Shin, Ki-Hyuk, Sohn, Suhjin   +5 more
core   +1 more source

Localization and synthesis of prenylquinones in isolated outer and inner envelope membranes from spinach chloroplasts [PDF]

, 1985
The prenylquinone content and biosynthetic capabilities of membrane fractions enriched in outer and inner envelope membranes from spinach chloroplasts were analyzed.
Bligh, Block, Block, Block, Block, Block, Carde, Douce, Douce, Douce, Douce, Grumbach, Hutson, Jeffrey, Joo, Lichtenthaler, Lowry, Mayer, Pennock, Schultz, Soll, Soll, Soll, Threlfall   +23 more
core   +1 more source