Results 61 to 70 of about 32,987 (164)
Biology Open, 2016 RPGR (retinitis pigmentosa GTPase regulator) is a ciliary protein associated with several forms of inherited retinal degenerative diseases. PDE6D is a ubiquitously expressed prenyl-binding protein and involved in ciliary targeting of prenylated proteins.
Nirmal Dutta, Seongjin Seo
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Phytotherapy Research, EarlyView.Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández +5 more
wiley +1 more source
The tryptophan prenyltransferase ComQ from Bacillus subtilis 168 can prenylate daptomycin at Trp1
The FEBS Journal, EarlyView.ComQ168 from Bacillus subtilis 168 catalyzes C‐terminal tryptophan farnesylation of ComX to generate a competence‐inducing pheromone. Recombinant ComQ168 also modifies cyclic peptides, including Daptomycin, likely at the N‐terminal tryptophan. Structural modeling highlights a C‐terminal binding region, supporting substrate promiscuity and establishing ...
Yanli Xu +2 more
wiley +1 more source
Biotechnologie, Agronomie, Société et Environnement, 2014 Protein prenylation in insects: a potential target for the development of bio-rational insecticides targeting the Lepidoptera?. Short-chain prenyltransferases (farnesyl diphosphate synthase [FPPS] and geranylgeranyl diphosphate synthase [GGPPS]) and ...
Barbar, A., Cusson, M.
doaj
Plant, Cell &Environment, EarlyView.ABSTRACT Surface immune receptors such as flagellin‐sensitive 2 (FLS2) are critical for plant defence, and their accumulation at the plasma membrane is tightly controlled by the endomembrane system. Here, we identify the Arabidopsis thaliana prenylated Rab acceptor PRA1.F3 as a positive regulator required for efficient accumulation of FLS2 at the ...
Sung Hee Jo +4 more
wiley +1 more source
Refinement and prediction of protein prenylation motifs [PDF]
Genome Biology, 2005 AbstractWe refined the motifs for carboxy-terminal protein prenylation by analysis of known substrates for farnesyltransferase (FT), geranylgeranyltransferase I (GGT1) and geranylgeranyltransferase II (GGT2). In addition to the CaaX box for the first two enzymes, we identify a preceding linker region that appears constrained in physicochemical ...
Maurer-Stroh, Sebastian +1 more
openaire +2 more sources
RABGGTB plays a critical role in ALS pathogenesis
Brain Research BulletinAmyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with unknown causes, which mainly affects motor neurons in the anterior horn of the spinal cord, brain stem, and cerebral cortex, also known as motor neuron disease.
Haiyang Ma +7 more
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Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host
Reviews in Medical Virology, Volume 36, Issue 4, July 2026.ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini +4 more
wiley +1 more source
Communications Biology, 2021 Malhi et al. conduct a high-throughput screen to identify inhibitors of respiratory syncytial virus (RSV). They find that statins inhibit post-entry events in the replicative cycle of RSV through a combination of cholesterol and isoprenoid-mediated ...
Manpreet Malhi +4 more
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Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.This review provides an extensive and critical synthesis of current knowledge on umbelliprenin, integrating phytochemical, analytical, biological, ecological, and food science perspectives, and identifies priorities for future research. ABSTRACT Umbelliprenin (7‐farnesyloxycoumarin) is an oxyprenylated coumarin that has gained increasing attention in ...
Chiara Collevecchio +4 more
wiley +1 more source