Results 71 to 80 of about 3,381,535 (185)

RABGGTB plays a critical role in ALS pathogenesis

Brain Research Bulletin
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with unknown causes, which mainly affects motor neurons in the anterior horn of the spinal cord, brain stem, and cerebral cortex, also known as motor neuron disease.
Haiyang Ma, Jia Huo, Cheng Xin, Jing Yang, Qi Liu, Hui Dong, Rui Li, Yaling Liu   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, Volume 600, Issue 17, Page 2564-2578, September 2026.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Metabolic Labeling and Visualization of Isoprenoids Using Alkyne‐Modified DMAPP Analogs in Bacillus subtilis

Angewandte Chemie, Volume 138, Issue 35, 24 August 2026.
Fluorescence‐based visualization and targeted mass–spectrometric enrichment of membrane‐embedded isoprenoids in Bacillus subtilis via cell‐permeant, alkynylated DMAPP analogs. ABSTRACT Isoprenoids are a chemically and functionally diverse class of metabolites that underlie essential bacterial physiology including respiration and cell envelope ...
Zackary N. Hulsey, Dillon P. McBee, Claudia L. Dolan, Francis M. Rossi, Neil A. Truslow, Allyson R. Taylor, Thomas N. Trybala, Joshua A. Baccile   +7 more
wiley   +2 more sources

Statin-mediated disruption of Rho GTPase prenylation and activity inhibits respiratory syncytial virus infection

Communications Biology, 2021
Malhi et al. conduct a high-throughput screen to identify inhibitors of respiratory syncytial virus (RSV). They find that statins inhibit post-entry events in the replicative cycle of RSV through a combination of cholesterol and isoprenoid-mediated ...
Manpreet Malhi, Michael J. Norris, Wenming Duan, Theo J. Moraes, Jason T. Maynes   +4 more
doaj   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Characterization Of Protein Prenyltransferases And Protein Prenylation In Plasmodium Falciparum [PDF]

, 2004
Malaria kills at least one million people each year, mostly children - a death every 30 seconds. Almost one half of the world population is at risk from malaria.
DaSilva, Thiago Gaspar
core  

Metabolic Reprogramming of Cancer Stem Cells: Targeting Lipid Flux and Mitochondrial Plasticity to Overcome Therapeutic Resistance

Cancer Medicine, Volume 15, Issue 9, September 2026.
Metabolic reprogramming in cancer stem cells: lipid flux, mitochondrial plasticity, and therapeutic resistance. Lipid metabolism in CSCs: de novo lipogenesis, CD36 uptake, FAO, lipid droplets, and membrane remodeling. Mitochondrial dynamics in CSC survival: fusion, fission, mitophagy, OXPHOS switching, and ROS regulation.
Daniel Ejim Uti, Esther Ugo Alum, Josephine E. Egbung, Zuhair M. Mohammedsaleh, Manpreet Kaur, Kranti Kiran Reddy Ealla   +5 more
wiley   +1 more source

Endophytic Fungi Natural Factories of Novel Bioactive Compounds

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
This review provides a systematic analysis of 242 natural products isolated from 42 genera of endophytic fungi, highlighting their remarkable structural diversity and broad spectrum of biological activities . ABSTRACT Endophytic fungi represent a prolific and chemically diverse source of novel specialized metabolites with significant pharmacological ...
Dilmurod Murodullayev, Jakhongir Movlanov, Liu Wei, Wei Liu, Maksud Isokov, Santosh Kumar Bose, Fazliddin Kobilov, Zamira Djumayeva, Buston Islamov, Jamila Sherkulova, Zafar Matyakubov, Muniskhon Meylieva, Munisa Ergasheva, Diyor Abduraxmanov, Guozheng Huang, Hongchen Jiang, Kakhramon Davranov, Guohui Pan, Nigora Rustamova   +18 more
wiley   +1 more source

Geranylgeraniol (GGOH) as a Mevalonate Pathway Activator in the Rescue of Bone Cells Treated with Zoledronic Acid: An In Vitro Study

Stem Cells International, 2019
Bisphosphonates (BPs) are the keystone to treat bone disorders. Despite the great benefits of BPs, medication-related osteonecrosis of the jaw (MRONJ) arouse as a potential side effect.
Riham M. Fliefel, Saleh A. Entekhabi, Michael Ehrenfeld, Sven Otto   +3 more
doaj   +1 more source

Farnesylation of the Transducin G Protein Gamma Subunit Is a Prerequisite for Its Ciliary Targeting in Rod Photoreceptors

Frontiers in Molecular Neuroscience, 2018
Primary cilia are microtubule-based organelles, which protrude from the plasma membrane and receive a wide range of extracellular signals. Various cilia use G protein-coupled receptors (GPCRs) for the detection of these signals.
Celine Brooks, Joseph Murphy, Marycharmain Belcastro, Daniel Heller, Saravanan Kolandaivelu, Oleg Kisselev, Maxim Sokolov, Maxim Sokolov   +7 more
doaj   +1 more source