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Protein Prenylation and Their Applications

Prenylation is a universal covalent post-translational modification found in all eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. Prenyl group is important for protein-protein binding through specialized prenyl-binding domains.
Khemchand R. Surana, Ritesh B. Pawar, Ritesh A. Khairnar, Sunil K. Mahajan   +3 more
openaire   +1 more source

Structure Prediction and Genome Mining‐Aided Discovery of the Bacterial C‐Terminal Tryptophan Prenyltransferase PalQ

Advanced Science
Post‐translational prenylations, found in eukaryotic primary metabolites and bacterial secondary metabolites, play crucial roles in biomolecular interactions.
Azusa Miyata, Sohei Ito, Daisuke Fujinami   +2 more
doaj   +1 more source

Geranylgeranyl isoprenoids and hepatic Rap1a regulate basal and statin-induced expression of PCSK9

Journal of Lipid Research
LDL-C lowering is the main goal of atherosclerotic cardiovascular disease prevention, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is now a validated therapeutic strategy that lowers serum LDL-C and reduces coronary events ...
Yating Wang, Brea Tinsley, Stefano Spolitu, John A. Zadroga, Heena Agarwal, Amesh K. Sarecha, Lale Ozcan   +6 more
doaj   +1 more source

Methyl-Jasmonate Functions as a Molecular Switch Promoting Cross-Talk between Pathways for the Biosynthesis of Isoprenoid Backbones Used to Modify Proteins in Plants

Plants
In plants, the plastidial mevalonate (MVA)-independent pathway is required for the modification with geranylgeranyl groups of CaaL-motif proteins, which are substrates of protein geranylgeranyltransferase type-I (PGGT-I).
Quentin Chevalier, Alexandre Huchelmann, Pauline Debié, Pierre Mercier, Michael Hartmann, Catherine Vonthron-Sénécheau, Thomas J. Bach, Hubert Schaller, Andréa Hemmerlin   +8 more
doaj   +1 more source

Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T_reg Cells. [PDF]

Cell Metab, 2020
Su W, Chapman NM, Wei J, Zeng H, Dhungana Y, Shi H, Saravia J, Zhou P, Long L, Rankin S, Kc A, Vogel P, Chi H.   +12 more
europepmc   +1 more source

Metformin Suppresses Cancer Stem Cells through AMPK Activation and Inhibition of Protein Prenylation of the Mevalonate Pathway in Colorectal Cancer. [PDF]

Cancers (Basel), 2020
Seo Y, Kim J, Park SJ, Park JJ, Cheon JH, Kim WH, Kim TI.   +6 more
europepmc   +1 more source

Novel benzimidazole phosphonates as potential inhibitors of protein prenylation. [PDF]

Bioorg Med Chem Lett, 2019
Bhuiyan NH, Varney ML, Wiemer DF, Holstein SA.   +3 more
europepmc   +1 more source

Protein Prenylation Makeovers in Plants: Insights into Substrate Diversification. [PDF]

Int J Mol Sci
Chevalier Q, Debié P, Huchelmann A, Hemmerlin A.   +3 more
europepmc   +1 more source

Inhibition of Protein Prenylation of GTPases Alters Endothelial Barrier Function. [PDF]

Int J Mol Sci, 2019
Aslam M, Troidl C, Tanislav C, Rohrbach S, Gündüz D, Hamm CW.   +5 more
europepmc   +1 more source

Engineering protein prenylation: an emerging tool for selective protein modification. [PDF]

Biochem Soc Trans
Venkatachalapathy S, Lichtenfels C, Wagner CR, Distefano MD.   +3 more
europepmc   +1 more source