Results 91 to 100 of about 3,381,535 (185)

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Journal of Lipid Research, 2011
Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenylation.
Brian M. Wasko, Jacqueline P. Smits, Larry W. Shull, David F. Wiemer, Raymond J. Hohl   +4 more
doaj   +1 more source

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth

Cell Reports, 2016
Suboptimal axonal regeneration contributes to the consequences of nervous system trauma and neurodegenerative disease, but the intrinsic mechanisms that regulate axon growth remain unclear.
Hai Li, Takaaki Kuwajima, Derek Oakley, Elena Nikulina, Jianwei Hou, Wan Seok Yang, Emily Rhodes Lowry, Nuno Jorge Lamas, Mackenzie Weygandt Amoroso, Gist F. Croft, Raghavendra Hosur, Hynek Wichterle, Said Sebti, Marie T. Filbin, Brent Stockwell, Christopher E. Henderson   +15 more
doaj   +1 more source

CpG Methylation of Protein Prenyltransferase Genes FNTA, FNTB, PGGT1B and RABGGTA in Cancer Cell Lines

Epigenomes
Background: Protein prenylation is crucial for the function of hundreds of proteins. Aberrant protein prenylation can be caused by the aberrant expression of prenyltransferases (PTases), which has been reported for multiple cancer entities.
Dominik Jung, Daniel Diehl, Anna Hagemann, Hagen Sjard Bachmann   +3 more
doaj   +1 more source

Design and application of in vivo FRET biosensors to identify protein prenylation and nanoclustering inhibitors [PDF]

, 2012
Protein prenylation is required for membrane anchorage of small GTPases. Correct membrane targeting is essential for their biological activity. Signal output of the prenylated proto-oncogene Ras in addition critically depends on its organization into ...
Abankwa, Daniel, Kohnke, Monika, Piggott, Andrew, Lacey, Ernest, Parton, Robert G., Ariotti, Nicholas, Alexandrov, Kirill, Piggott, Andrew M., Capon, Robert, Schmitt, Steven, Capon, Robert J.   +10 more
core   +1 more source

β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage

, 2012
Accumulation of β-amyloid (Aβ) inside brain neurons is an early and crucial event in Alzheimer's disease (AD). Studies in brains of AD patients and mice models of AD suggested that cholesterol homeostasis is altered in neurons that accumulate Aβ. Here we
Saavedra, Maria Lucila, Posse de Chaves, Elena, Sipione, Simonetta, Mohamed, Amany, Di Pardo, Alba   +4 more
core   +1 more source

Enzymology and Biology of CaaX Protein Prenylation

, 2014
[[abstract]]Protein prenylation refers to a type of lipid modification in which tither a 15-carbon farnesyl or 20-carbon geranylgeranyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins.
Fu, HW;Casey, PJ
core  

Therapeutic intervention based on protein prenylation and associated modifications

, 2006
In eukaryotic cells, a specific set of proteins are modified by C-terminal attachment of 15-carbon farnesyl groups or 20-carbon geranylgeranyl groups that function both as anchors for fixing proteins to membranes and as molecular handles for facilitating
Michaelis, S, Brunsveld, L., Gelb, M.H., Tamanoi, F., Hrycyna, C.A., Michaelis, S., Brunsveld, L Luc, Gelb, MH, Tamanoi, F, Hrycyna, CA, Brunsveld, L.; id_orcid   +10 more
core   +1 more source

Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species. [PDF]

J Biol Chem, 2023
Sang Y, Yang Q, Guo Y, Liu X, Shen D, Jiang C, Wang X, Li K, Wang H, Yang C, Ding L, Sun H, Guo X, Li C.   +13 more
europepmc   +1 more source

Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4Summary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Metabolically unhealthy obesity (MUO) is characterized by hepatic steatosis and type 2 diabetes (T2D), distinct from metabolically healthy obesity (MHO). This study aimed to identify the key regulator responsible for MUO.
Yue Zhao, Hong-Yu Nie, Shan Jiang, Meng-Fei Zhao, Peng Sun, Jing-Zi Zhang, Xiao-Chen Wang, Yi-Ping Tang, Ming-jie Zou, Xian-Wen Yuan, Xi-Tai Sun, Xiao-Dong Shan, Jian He, Jiang-Huai Liu, Yan Bi, Lei Fang, Xiao Han, Chao-Jun Li   +17 more
doaj   +1 more source

Studies of protein prenylation in living systems: implications toward the better understanding of diseases

, 2012
University of Minnesota Ph.D. dissertation. August 2012. Major: Chemistry. Advisor: Dr. Mark D. Distefano. 1 computer file (PDF); xv, 199 pages, appendices A-B.Protein prenylation is a post-translational modification that is present in a large number of ...
Ochocki, Joshua Daniel
core