Results 111 to 120 of about 40,533 (205)

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Journal of Lipid Research, 2011
Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenylation.
Brian M. Wasko, Jacqueline P. Smits, Larry W. Shull, David F. Wiemer, Raymond J. Hohl   +4 more
doaj   +1 more source

Geranylgeranyltransferase I is essential for dendritic development of cerebellar Purkinje cells [PDF]

, 2010
Background During cerebellar development, Purkinje cells (PCs) form the most elaborate dendritic trees among neurons in the brain, but the mechanism regulating PC arborization remains largely unknown.
Kong-Yan Wu, Xiu-Ping Zhou, Zhen-Ge Luo
core   +2 more sources

Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency [PDF]

, 1871
Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase gene (MVK). MKD has heterogeneous clinical phenotypes: the correlation between MVK mutations and MKD clinical phenotype is still to be fully elucidated ...
Tricarico, Paola Maura, Romeo, Alessandra, Gratton, Rossella, Crovella, Sergio, Celsi, Fulvio   +4 more
core   +2 more sources

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth

Cell Reports, 2016
Suboptimal axonal regeneration contributes to the consequences of nervous system trauma and neurodegenerative disease, but the intrinsic mechanisms that regulate axon growth remain unclear.
Hai Li, Takaaki Kuwajima, Derek Oakley, Elena Nikulina, Jianwei Hou, Wan Seok Yang, Emily Rhodes Lowry, Nuno Jorge Lamas, Mackenzie Weygandt Amoroso, Gist F. Croft, Raghavendra Hosur, Hynek Wichterle, Said Sebti, Marie T. Filbin, Brent Stockwell, Christopher E. Henderson   +15 more
doaj   +1 more source

Nerve growth factor induces neurite outgrowth of PC12 cells by promoting Gβγ-microtubule interaction [PDF]

, 2014
Background: Assembly and disassembly of microtubules (MTs) is critical for neurite outgrowth and differentiation. Evidence suggests that nerve growth factor (NGF) induces neurite outgrowth from PC12 cells by activating the receptor tyrosine kinase, TrkA.
A Hall, A Patapoutian, AD Cash, AM Winter-Vann, Armando Varela-Ramirez, Arshad M Khan, B Aguilar, B Lotto, B Stoyanov, BS Reinoso, C Conde, C Lema, CG Dotti, CM Stern, D Cartelli, D Cartelli, D Purves, E,M Hur, EE Govek, EH Wu, EH Wu, EJ Yoon, Ellen M Walker, EMM Manders, F Goubaeva, FQ Zhou, G Banker, GA Buxton, H Okae, H Towbin, H Tummala, I Azpiazu, I Azpiazu, I Cushman, J Garcia-Olivares, JA Harrill, JC Bulinski, JC He, Jessica Martinez-Jurado, JH Kwon, Jorge A Sierra-Fonseca, JZ Yu, K Sanada, K Wang, KJ De Vos, LA Greene, LC Cantley, LL Gomez, LR Stephens, M Igarashi, M Koehl, MA Franker, Manuel Miranda, MH Gelb, MX Ibrahim, N Macrez, Nazarius S Lamango, NS Lamango, NS Lamango, NS Lamango, Omar Najera, P Sachdev, S Millecamps, S Roychowdhury, S Roychowdhury, S Roychowdhury, S Tahirovic, SK Powell, Sukla Roychowdhury, T Blackmer, T Mitchison, T Sarma, U Marklund, UK Laemmli, V Montoya, VC Dang, WJ Koch   +76 more
core   +2 more sources

Inhibition of Prenylation Promotes Caspase 3 Activation, Lamin B Degradation and Loss in Metabolic Cell Viability in Pancreatic β-Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Lamins are intermediate filament proteins that constitute the main components of the lamina underlying the inner-nuclear membrane and serve to organize chromatin.
Khadija G. Syeda, Anjan Kowluru
doaj   +1 more source

Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species. [PDF]

J Biol Chem, 2023
Sang Y, Yang Q, Guo Y, Liu X, Shen D, Jiang C, Wang X, Li K, Wang H, Yang C, Ding L, Sun H, Guo X, Li C.   +13 more
europepmc   +1 more source

Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4Summary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Metabolically unhealthy obesity (MUO) is characterized by hepatic steatosis and type 2 diabetes (T2D), distinct from metabolically healthy obesity (MHO). This study aimed to identify the key regulator responsible for MUO.
Yue Zhao, Hong-Yu Nie, Shan Jiang, Meng-Fei Zhao, Peng Sun, Jing-Zi Zhang, Xiao-Chen Wang, Yi-Ping Tang, Ming-jie Zou, Xian-Wen Yuan, Xi-Tai Sun, Xiao-Dong Shan, Jian He, Jiang-Huai Liu, Yan Bi, Lei Fang, Xiao Han, Chao-Jun Li   +17 more
doaj   +1 more source

Mevalonate metabolism governs cancer immune surveillance

OncoImmunology, 2017
The metabolic reprogramming that drives immunity engages the mevalonate pathway for cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this metabolic route is reflected by the fact that too low activity impairs ...
Georg Gruenbacher, Martin Thurnher
doaj   +1 more source

Structure Prediction and Genome Mining‐Aided Discovery of the Bacterial C‐Terminal Tryptophan Prenyltransferase PalQ

Advanced Science
Post‐translational prenylations, found in eukaryotic primary metabolites and bacterial secondary metabolites, play crucial roles in biomolecular interactions.
Azusa Miyata, Sohei Ito, Daisuke Fujinami   +2 more
doaj   +1 more source