Results 121 to 130 of about 32,987 (164)

Discovery of unprecedented prenylated indole piperazines and pyrazines through cryptic biosynthetic gene cluster heterologous expression. [PDF]

Nat Prod Bioprospect
Zha Z, He D, Song J, Guan Z, Han J, Liu C, Wang X, Zhu Y, Zhu H, Ye W, Li Q, Zhang Y, Zhou Y.   +12 more
europepmc   +1 more source

Tuning aromatic cage occupancy in prenyltransferases enables selective and efficient production of rare c-prenylated flavonoids. [PDF]

Nat Commun
Qiu R, Huang H, Chi J, Gao L, Gao Q, Li M, Cai M, Yu H, Wang S, Qian Z, Jiang M, Liu Y, Chen B, Zhou Y, Zhang ZM, Wang JB.   +15 more
europepmc   +1 more source

The antitumoral effect of statins in pancreatic ductal adenocarcinoma: a scoping review. [PDF]

Front Pharmacol
Pîntea AI, Croitoru AE, Dinu-Pîrvu CE, Dima SO.   +3 more
europepmc   +1 more source

With a little help from a friend - a new partner for acid-sensitive channels. [PDF]

Pflugers Arch
Roeper J.
europepmc   +1 more source

Prenylated apigenin derivatives from Cannabis sativa L.: isolation, biosynthesis, and anti-inflammatory properties. [PDF]

J Cannabis Res
Bodnar UKC, Villemaire-McCutcheon JJ, Boddington KF, Soubeyrand E, Al-Abdul-Wahid MS, Robeson HN, Lalonde J, Casaretto JA, Akhtar TA.   +8 more
europepmc   +1 more source

Lipopolysaccharide stimulates dynamic changes in B cell metabolism to promote proliferation. [PDF]

Elife
Cheung DMS, Razsolkov M, Bonacina F, Andrews S, Sumoreeah MC, Sinclair LV, Howden AJM, Arthur JSC.   +7 more
europepmc   +1 more source

Regulation of protein prenylation

Biomedicine and Pharmacotherapy, 2023
Prenyltransferases (PTases) are known to play a role in embryonic development, normal tissue homeostasis and cancer by posttranslationally modifying proteins involved in these processes. They are being discussed as potential drug targets in an increasing number of diseases, ranging from Alzheimer's disease to malaria.
Dominik Jung, Hagen S Bachmann
exaly   +3 more sources

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The prenylation of proteins

BioEssays, 1992
AbstractThe prenylated proteins represent a newly discovered class of post‐translationally modified proteins. The known prenylated proteins include the oncogene product p21ras and other low molecular weight GTP‐binding proteins, the nuclear lamins, and the γ subunit of the heterotrimeric G proteins.
M, Sinensky, R J, Lutz
openaire   +2 more sources

Targeting protein prenylation for cancer therapy [PDF]

Nature Reviews Cancer, 2011
Protein farnesylation and geranylgeranylation, together referred to as prenylation, are lipid post-translational modifications that are required for the transforming activity of many oncogenic proteins, including some RAS family members. This observation prompted the development of inhibitors of farnesyltransferase (FT) and geranylgeranyl-transferase 1
Norbert Berndt, Andrew D Hamilton, Said M Sebti   +2 more
exaly   +3 more sources

Prenylated proteins from kidney

Biochemical and Biophysical Research Communications, 1986
When [5-3H]mevalonate is injected into mice, it is incorporated into macromolecules in the kidney. The incorporated material is stable to treatment with RNase or DNase but not protease, indicating that the radioactivity is associated with protein. Electrophoresis in sodium dodecyl sulfate-containing polyacrylamide gels indicates a molecular weight of ...
E, Bruenger, H C, Rilling
openaire   +2 more sources