Results 141 to 150 of about 32,987 (164)
Some of the next articles are maybe not open access.
Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1
Bioorganic & Medicinal Chemistry Letters, 2001Several compounds designed as bisubstrate analogues of protein farnesyltransferase inhibited the prenyl protein-specific protease Rce1, qualifying them as lead structures for a novel class of non-peptidic, non-prenylic inhibitors of this protease.
M, Schlitzer, A, Winter-Vann, P J, Casey
openaire +2 more sources
Development of hydrophobicity parameters for prenylated proteins
Biochemical and Biophysical Research Communications, 1992We have determined hydrophobicity parameters for the side-chains of the prenyl thioether protein modifications, farnesyl-cysteine and geranylgeranyl-cysteine. Farnesyl-Cys is somewhat more hydrophobic than palmitoyl-Cys, but geranylgeranyl-Cys is more than two log(P) units more non-polar.
openaire +2 more sources
Recent advances in the study of prenylated proteins
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000Post-translational modification of proteins with isoprenoids was first recognized as a general phenomenon in 1984. In recent years, our understanding, including mechanistic studies, of the enzymatic reactions associated with these modifications and their physiological functions has increased dramatically.
openaire +3 more sources
Analysis of Protein Prenylation and Carboxyl‐Methylation
Current Protocols in Protein Science, 1996AbstractThis unit describes methods for analysis of prenylation and the carboxyl‐methylation that often accompanies it. The two prenoid groups that have been found attached to proteins‐‐farnesyl (C15) and geranylgeranyl (C20)‐‐are both derived from intermediates in the isoprenoid biosynthetic pathway that utilizes mevalonic acid.
openaire +2 more sources
Acylation and prenylation of proteins
Current Opinion in Cell Biology, 1990R J, Deschenes, M D, Resh, J R, Broach
openaire +2 more sources