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Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer’s disease [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2018
Kiall Francis Suazo, Mark Distefano, Angela Jeong   +2 more
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The prenylation of proteins

BioEssays, 1992
AbstractThe prenylated proteins represent a newly discovered class of post‐translationally modified proteins. The known prenylated proteins include the oncogene product p21ras and other low molecular weight GTP‐binding proteins, the nuclear lamins, and the γ subunit of the heterotrimeric G proteins.
M, Sinensky, R J, Lutz
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Protein Prenylation and Synaptic Plasticity: Implications for Alzheimer’s Disease [PDF]

Molecular Neurobiology, 2014
Ling Li
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Prenylation of proteins in Trypanosoma brucei

Molecular and Biochemical Parasitology, 1997
Prenyl modification of proteins by farnesyl and geranylgeranyl isoprenoids occurs in a variety of eukaryotic cells. Culturing of Trypanosoma brucei in the presence of [3H]mevalonolactone (which is hydrolyzed in cells to give mevalonic acid, the precursor of protein prenyl groups) and an inhibitor of mevalonic acid biosynthesis leads to the ...
K, Yokoyama, Y, Lin, K D, Stuart, M H, Gelb   +3 more
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Prenylated proteins from kidney

Biochemical and Biophysical Research Communications, 1986
When [5-3H]mevalonate is injected into mice, it is incorporated into macromolecules in the kidney. The incorporated material is stable to treatment with RNase or DNase but not protease, indicating that the radioactivity is associated with protein. Electrophoresis in sodium dodecyl sulfate-containing polyacrylamide gels indicates a molecular weight of ...
E, Bruenger, H C, Rilling
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Prenylation and G Protein Signaling

1994
Publisher Summary This chapter presents recent studies in the field of protein prenylation, with particular emphasis on the enzymology of these processes and the influence of the modifications on specific G proteins involved in cellular signaling. The known prenylated proteins include a number of GTP-binding regulatory proteins (G proteins); these ...
P J, Casey, J F, Moomaw, F L, Zhang, Y B, Higgins, J A, Thissen   +4 more
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Antigenic Prenylated Peptide Conjugates and Polyclonal Antibodies To Detect Protein Prenylation

Bioconjugate Chemistry, 2004
Posttranslational modification of proteins with farnesyl and geranylgeranyl groups is a required modification for signaling proteins that includes the small GTPases in the Ras, Rho, and Rab families, heterotrimeric G proteins, and nuclear lamin proteins.
Xiao-hui, Liu, Dae-Yeon, Suh, Jeffrey, Call, Glenn D, Prestwich   +3 more
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Prenylated Proteins in Regenerating Rat Liver

Biochemical and Biophysical Research Communications, 1994
During rat liver regeneration, at the onset of S-phase of the first cell cycle, an enhanced mevalonate incorporation into prenylated proteins is observed. The analysis of the lipid moieties of such proteins shows a 20-fold increased content of geraniol and farnesol. The expected increase of farnesylated and geranylgeranylated proteins in pre-S phase is
G, Bruscalupi, F, Castellano, S, Sacco, A, Trentalance   +3 more
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Occurrence of Prenylated Proteins in Plant Cells

Biochemical and Biophysical Research Communications, 1993
In this paper evidence is presented for the occurrence of prenylated proteins in plants. When spinach leaves were incubated in the presence of [3H]mevalonate non-extractable lipids were found in the protein fraction after extraction with organic solvents.
E, Swiezewska, A, Thelin, G, Dallner, B, Andersson, L, Ernster   +4 more
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Analysis of the Stoichiometry of Rab Protein Prenylation

Analytical Biochemistry, 1995
Rab5 is a Ras-related GTP-binding protein that is post-translationally prenylated with the 20-carbon isoprenoid geranylgeranyl. We have developed a method to determine the stoichiometry of prenylation of Rab5, and Rab family members in general, based on the cell-free translation of these peptides in the presence or the absence of appropriate ...
J C, Sanford, L, Foster, Z, Kapadia, M, Wessling-Resnick   +3 more
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