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Inhibition of protein prenylation by metabolites of limonene
Biochemical Pharmacology, 1999The monoterpenes limonene and perillyl alcohol are undergoing clinical evaluation in cancer patients. In this paper, we report the chemical synthesis, characterisation, and quantitation in patients' plasma of a novel human metabolite of limonene, which is identified as an isomer of perillic acid.
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Protein Prenylation in Tetrahymena
Archiv für Protistenkunde, 1996Summary Tetrahymena vorax V 2S and Tetrahymena pyriformis GL were examined for the presence of proteins covalently modified with mevalonate-derived lipids. Radiolabeling of cells using [3H]mevalonolactone, [ 3 H]mevalonate, [ 3 H]farnesyl pyrophosphate or [ 3 H]geranylgeranyl pyrophosphate resulted in the appearance of protein-associated ...
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Acylation and prenylation of proteins
Current Opinion in Cell Biology, 1990R J, Deschenes, M D, Resh, J R, Broach
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Analysis of Protein Prenylation and Carboxyl‐Methylation
Current Protocols in Protein Science, 1996AbstractThis unit describes methods for analysis of prenylation and the carboxyl‐methylation that often accompanies it. The two prenoid groups that have been found attached to proteins‐‐farnesyl (C15) and geranylgeranyl (C20)‐‐are both derived from intermediates in the isoprenoid biosynthetic pathway that utilizes mevalonic acid.
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Development of hydrophobicity parameters for prenylated proteins
Biochemical and Biophysical Research Communications, 1992We have determined hydrophobicity parameters for the side-chains of the prenyl thioether protein modifications, farnesyl-cysteine and geranylgeranyl-cysteine. Farnesyl-Cys is somewhat more hydrophobic than palmitoyl-Cys, but geranylgeranyl-Cys is more than two log(P) units more non-polar.
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Recent advances in the study of prenylated proteins
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2000Post-translational modification of proteins with isoprenoids was first recognized as a general phenomenon in 1984. In recent years, our understanding, including mechanistic studies, of the enzymatic reactions associated with these modifications and their physiological functions has increased dramatically.
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