Results 171 to 180 of about 40,533 (205)
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Protein Prenylation in Tetrahymena
Archiv für Protistenkunde, 1996Summary Tetrahymena vorax V 2S and Tetrahymena pyriformis GL were examined for the presence of proteins covalently modified with mevalonate-derived lipids. Radiolabeling of cells using [3H]mevalonolactone, [ 3 H]mevalonate, [ 3 H]farnesyl pyrophosphate or [ 3 H]geranylgeranyl pyrophosphate resulted in the appearance of protein-associated ...
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REP-Mediated Protein Prenylation
1998Addition of isoprenoids to polypeptides is a common post-translational modification occurring in yeast, animal and plant cells. Isoprenoid precursors are derived from the mevalonate pathway and are incorporated into many cellular products such as sterols, heme A, ubiquinone, dolichols, carotenoids and prenylated proteins (Goldstein and Brown, 1990).
U. Bialek +5 more
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Archives of Biochemistry and Biophysics, 1992
It has been established that vertebrates and yeasts modified a unique subset of polypeptides with farnesyl and geranylgeranyl residues. This observation has been extended to Drosophila Kc cells. [3H]Mevalonate was incorporated into 54 Kc cell peptides (18-92 kDa).
C M, Havel, P, Fisher, J A, Watson
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It has been established that vertebrates and yeasts modified a unique subset of polypeptides with farnesyl and geranylgeranyl residues. This observation has been extended to Drosophila Kc cells. [3H]Mevalonate was incorporated into 54 Kc cell peptides (18-92 kDa).
C M, Havel, P, Fisher, J A, Watson
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Inhibitors of protein prenylation 1999
Expert Opinion on Therapeutic Patents, 1999Interest in farnesyltransferase inhibitors (FTIs) as a potential cancer therapy continues, judging from the approximately eighty patent applications published in the fourteen month period from January 1998. This review summarises progress in the field since the previous update [1] and includes a description of the first clinical trials in man.
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Inhibitors of protein prenylation 2000
Expert Opinion on Therapeutic Patents, 2000The development of farnesyltransferase inhibitors (FTIs) was conceived of as a rational approach to the design of new cancer chemotherapeutics and the first examples of this class are currently being evaluated in Phase II and Phase III clinical trials.
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Structural analysis of prenylated proteins
1992Abstract The post-translational attachment of prenyl groups to proteins in eukaryotic cells has been recently reported (1-4). To date, two isoprenoid products derived from mevalonic acid (MVA), 15-carbon farnesyl groups or 20-carbon geranylgeranyl groups, have been detected.
Michael H Gelb +2 more
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Puzzling Promise Of Protein Prenylation
Chemical & Engineering News Archive, 1998From the ACS meeting Sometimes, you just get lucky, says Patrick J. Casey, associate professor of pharmacology and cancer biology at Duke University Medical Center. A case in point is the class of compounds that inhibits the enzyme farnesyltransferase. Designed to be anticancer drugs, the first of these compounds are entering trials in cancer patients.
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Prenylated Proteins in Peroxisome Biogenesis
2011Publisher Summary This chapter discusses the role of prenylated proteins in peroxisome biogenesis. Peroxisomes or microbodies are a family of functionally and structurally related organelles of eukaryotic cells. They are surrounded by a single lipid bilayer membrane and have a diameter of 0.1–1 μm.
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