Results 161 to 170 of about 40,533 (205)

Comparative study of palmitoleic acid, sea buckthorn oil, and lovastatin in hepatocellular steatosis model. [PDF]

Sci Rep
Szustak M, Pichlak M, Korkus E, Kamińska D, Koziołkiewicz M, Dąbrowski G, Czaplicki S, Konopka I, Gendaszewska-Darmach E.   +8 more
europepmc   +1 more source

Targeting ICMT: A promising strategy in cancer treatment (Review). [PDF]

Oncol Lett
Hu J, Xiao Y, Tang J.
europepmc   +1 more source

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PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS

Annual Review of Genetics, 1992
PROTEINS INVOLVED IN PRENYL-DEPENDENT PROCESSING 217 Protein Prenyltransferases 218 Proteases 221 Reversible Modifications 223 PRENYL-MEDIATED INTERACTIONS 225 Prenyl-protein Receptors 225 Lipid Interactions 227 Indirect Prenyl-dependent Targeting ...
W R, Schafer, J, Rine
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The prenylation of proteins

BioEssays, 1992
AbstractThe prenylated proteins represent a newly discovered class of post‐translationally modified proteins. The known prenylated proteins include the oncogene product p21ras and other low molecular weight GTP‐binding proteins, the nuclear lamins, and the γ subunit of the heterotrimeric G proteins.
M, Sinensky, R J, Lutz
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Prenylated proteins from kidney

Biochemical and Biophysical Research Communications, 1986
When [5-3H]mevalonate is injected into mice, it is incorporated into macromolecules in the kidney. The incorporated material is stable to treatment with RNase or DNase but not protease, indicating that the radioactivity is associated with protein. Electrophoresis in sodium dodecyl sulfate-containing polyacrylamide gels indicates a molecular weight of ...
E, Bruenger, H C, Rilling
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Antigenic Prenylated Peptide Conjugates and Polyclonal Antibodies To Detect Protein Prenylation

Bioconjugate Chemistry, 2004
Posttranslational modification of proteins with farnesyl and geranylgeranyl groups is a required modification for signaling proteins that includes the small GTPases in the Ras, Rho, and Rab families, heterotrimeric G proteins, and nuclear lamin proteins.
Xiao-hui, Liu, Dae-Yeon, Suh, Jeffrey, Call, Glenn D, Prestwich   +3 more
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Prenylation and G Protein Signaling

1994
Publisher Summary This chapter presents recent studies in the field of protein prenylation, with particular emphasis on the enzymology of these processes and the influence of the modifications on specific G proteins involved in cellular signaling. The known prenylated proteins include a number of GTP-binding regulatory proteins (G proteins); these ...
P J, Casey, J F, Moomaw, F L, Zhang, Y B, Higgins, J A, Thissen   +4 more
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Prenylation of proteins in Trypanosoma brucei

Molecular and Biochemical Parasitology, 1997
Prenyl modification of proteins by farnesyl and geranylgeranyl isoprenoids occurs in a variety of eukaryotic cells. Culturing of Trypanosoma brucei in the presence of [3H]mevalonolactone (which is hydrolyzed in cells to give mevalonic acid, the precursor of protein prenyl groups) and an inhibitor of mevalonic acid biosynthesis leads to the ...
K, Yokoyama, Y, Lin, K D, Stuart, M H, Gelb   +3 more
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Prenylated Proteins in Regenerating Rat Liver

Biochemical and Biophysical Research Communications, 1994
During rat liver regeneration, at the onset of S-phase of the first cell cycle, an enhanced mevalonate incorporation into prenylated proteins is observed. The analysis of the lipid moieties of such proteins shows a 20-fold increased content of geraniol and farnesol. The expected increase of farnesylated and geranylgeranylated proteins in pre-S phase is
G, Bruscalupi, F, Castellano, S, Sacco, A, Trentalance   +3 more
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Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1

Bioorganic & Medicinal Chemistry Letters, 2001
Several compounds designed as bisubstrate analogues of protein farnesyltransferase inhibited the prenyl protein-specific protease Rce1, qualifying them as lead structures for a novel class of non-peptidic, non-prenylic inhibitors of this protease.
M, Schlitzer, A, Winter-Vann, P J, Casey
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