Results 101 to 110 of about 3,381,535 (185)

Depletion of substrates for protein prenylation increases apoptosis in human periovulatory granulosa cells

, 2006
Progesterone receptor (PR) stimulation promotes survival in human and rat periovulatory granulosa cells. PR antagonists, Org 31710 and RU 486, both increase apoptosis and decrease cholesterol synthesis in these cells.
Rung, Emilia,, Bergh, Christina,, Billig, Håkan,, Friberg, P. Anders,   +3 more
core   +1 more source

Probes for protein prenylation [PDF]

Nature Methods, 2019
openaire   +2 more sources

Role of inhibition of protein prenylation in the cholesterol-dependent and cholesterol-independent effects of simvastatin

, 2006
Statins are widely used to treat hypercholesterolemia. Statins inhibit cholesterol biosynthesis, thereby activating genes involved in cholesterol homeostasis, which are under the control of the Sterol Regulatory Element (SRE).
Volk, Catherine B.
core  

Tools for the modulation and identification of protein prenylation

, 2006
Protein prenylation is an essential posttranslational modification for many important signaling molecules. Prenyl addition anchors the protein to membranes by a large hydrophobic lipid handle.
Reigard, Sarah Annette
core   +1 more source

Structure Prediction and Genome Mining‐Aided Discovery of the Bacterial C‐Terminal Tryptophan Prenyltransferase PalQ

Advanced Science
Post‐translational prenylations, found in eukaryotic primary metabolites and bacterial secondary metabolites, play crucial roles in biomolecular interactions.
Azusa Miyata, Sohei Ito, Daisuke Fujinami   +2 more
doaj   +1 more source

Protein Prenylation and Their Applications

Prenylation is a universal covalent post-translational modification found in all eukaryotic cells, comprising attachment of either a farnesyl or a geranylgeranyl isoprenoid. Prenyl group is important for protein-protein binding through specialized prenyl-binding domains.
Khemchand R. Surana, Ritesh B. Pawar, Ritesh A. Khairnar, Sunil K. Mahajan   +3 more
openaire   +1 more source

Case Report: Clinical application of an in vitro prenylation assay in the diagnosis of an early-onset case of mevalonate kinase deficiency harbouring a novel MVK variant

Frontiers in Pediatrics
Mevalonate kinase deficiency (MKD) is a systemic autoinflammatory disease caused by biallelic mutations in MVK. Individuals with MKD present with a recurrent fever syndrome, often including a skin rash, gastrointestinal symptoms and lymphadenopathy.
Alice Burleigh, Ovgu Kul Cinar, Paul Torpiano, Marcia A. Munoz, Marcia A. Munoz, Charlotte Abell-King, Charlotte Abell-King, Michael J. Rogers, Michael J. Rogers, Despina Eleftheriou, Despina Eleftheriou, Paul A. Brogan, Paul A. Brogan   +12 more
doaj   +1 more source

Geranylgeranyl isoprenoids and hepatic Rap1a regulate basal and statin-induced expression of PCSK9

Journal of Lipid Research
LDL-C lowering is the main goal of atherosclerotic cardiovascular disease prevention, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is now a validated therapeutic strategy that lowers serum LDL-C and reduces coronary events ...
Yating Wang, Brea Tinsley, Stefano Spolitu, John A. Zadroga, Heena Agarwal, Amesh K. Sarecha, Lale Ozcan   +6 more
doaj   +1 more source

Protein Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T_reg Cells. [PDF]

Cell Metab, 2020
Su W, Chapman NM, Wei J, Zeng H, Dhungana Y, Shi H, Saravia J, Zhou P, Long L, Rankin S, Kc A, Vogel P, Chi H.   +12 more
europepmc   +1 more source

Inhibition of Protein Prenylation: a Novel Approach in Antifungal Therapy

, 2011
Many proteins that are required for eukaryotic cell growth, differentiation, and cellular signaling pathways, including the Ras superfamily of GTP-binding proteins, go through prenylation, a post-translational modification of isoprenoid lipid attachment.
Tseng, Quincy
core   +1 more source