Results 81 to 90 of about 32,987 (164)

Phenolic Compounds: From Traditional Uses to Innovative Applications and Everything in Between

Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
This review deals with many aspects related to the study of phenolic compounds, starting with advances in extraction, detection, and quantification methods, going through bioavailability, bioactivity, and beneficial health properties, and discussing antioxidant and antimicrobial uses and mechanisms.
Marcela de Sá Barreto da Cunha, Cristina Maria Turim Santos Miguel, Emília Maria França Lima, Uelinton Manoel Pinto, Cláudia Vieira Prudêncio, Svetoslav Dimitrov Todorov   +5 more
wiley   +1 more source

Structure and Mechanism of PhdC, a Prenylated‐Flavin Maturase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 5, Page 1019-1029, May 2026.
ABSTRACT Prenylated flavin mononucleotide (prFMN) is a modified flavin cofactor required by the UbiD family of (de)carboxylase enzymes. While the reduced prFMNH2 form is produced by the flavin prenyltransferase UbiX, the corresponding two‐electron oxidized prFMNiminium form is required to support UbiD catalysis. Thus, oxidative maturation of prFMNH2 is
Dominic R. Whittall, Henry G. Box, Karl A. P. Payne, Stephen A. Marshall, David Leys   +4 more
wiley   +1 more source

Thematic review series: Lipid Posttranslational Modifications. Geranylgeranylation of Rab GTPases

Journal of Lipid Research, 2006
Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT.
Ka Fai Leung, Rudi Baron, Miguel C. Seabra   +2 more
doaj   +1 more source

A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro[S]

Journal of Lipid Research, 2011
Statins and nitrogenous bisphosphonates (NBP) inhibit 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR) and farnesyl diphosphate synthase (FDPS), respectively, leading to depletion of farnesyl diphosphate (FPP) and disruption of protein prenylation.
Brian M. Wasko, Jacqueline P. Smits, Larry W. Shull, David F. Wiemer, Raymond J. Hohl   +4 more
doaj   +1 more source

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth

Cell Reports, 2016
Suboptimal axonal regeneration contributes to the consequences of nervous system trauma and neurodegenerative disease, but the intrinsic mechanisms that regulate axon growth remain unclear.
Hai Li, Takaaki Kuwajima, Derek Oakley, Elena Nikulina, Jianwei Hou, Wan Seok Yang, Emily Rhodes Lowry, Nuno Jorge Lamas, Mackenzie Weygandt Amoroso, Gist F. Croft, Raghavendra Hosur, Hynek Wichterle, Said Sebti, Marie T. Filbin, Brent Stockwell, Christopher E. Henderson   +15 more
doaj   +1 more source

Chemical site-selective prenylation of proteins

Molecular BioSystems, 2008
Abstract A direct thionation procedure allows conversion of allylic alcohols into the corresponding thiols, the products of which are immediately compatible with one-pot site-selective selenenyl sulfide mediated proteinconjugation.
Gamblin, D, van Kasteren, S, Bernardes, G, Chalker, J, Oldham, N, Fairbanks, A, Davis, B   +6 more
openaire   +2 more sources

Inhibition of Prenylation Promotes Caspase 3 Activation, Lamin B Degradation and Loss in Metabolic Cell Viability in Pancreatic β-Cells

Cellular Physiology and Biochemistry, 2017
Background/Aims: Lamins are intermediate filament proteins that constitute the main components of the lamina underlying the inner-nuclear membrane and serve to organize chromatin.
Khadija G. Syeda, Anjan Kowluru
doaj   +1 more source

Oocytes orchestrate protein prenylation for mitochondrial function through selective inactivation of cholesterol biosynthesis in murine species. [PDF]

J Biol Chem, 2023
Sang Y, Yang Q, Guo Y, Liu X, Shen D, Jiang C, Wang X, Li K, Wang H, Yang C, Ding L, Sun H, Guo X, Li C.   +13 more
europepmc   +1 more source

Geranylgeranyl Pyrophosphate Promotes Hepatic Lipid Accumulation by Prenylation of Perilipin4Summary

Cellular and Molecular Gastroenterology and Hepatology
Background & Aims: Metabolically unhealthy obesity (MUO) is characterized by hepatic steatosis and type 2 diabetes (T2D), distinct from metabolically healthy obesity (MHO). This study aimed to identify the key regulator responsible for MUO.
Yue Zhao, Hong-Yu Nie, Shan Jiang, Meng-Fei Zhao, Peng Sun, Jing-Zi Zhang, Xiao-Chen Wang, Yi-Ping Tang, Ming-jie Zou, Xian-Wen Yuan, Xi-Tai Sun, Xiao-Dong Shan, Jian He, Jiang-Huai Liu, Yan Bi, Lei Fang, Xiao Han, Chao-Jun Li   +17 more
doaj   +1 more source

Mevalonate metabolism governs cancer immune surveillance

OncoImmunology, 2017
The metabolic reprogramming that drives immunity engages the mevalonate pathway for cholesterol biosynthesis and protein prenylation. The importance of tight regulation of this metabolic route is reflected by the fact that too low activity impairs ...
Georg Gruenbacher, Martin Thurnher
doaj   +1 more source