Results 51 to 60 of about 40,533 (205)

XDJ1, a gene encoding a novel non-essential DnaJ homologue from Saccharomyces cerevisiae [PDF]

, 1994
The gene encoding a novel DnaJ-like protein, termed Xdj1, has been identified by amplification of Saccharomyces cerevisiae genomic DNA. An open reading frame of 1380 bp was detected. Disruption of XDJ1 did not yield any detectable new phenotype. A double-
Caplan, Avrom J., Ludwig, Gabriele, Neupert, Walter, Schwarz, Elisabeth, Westermann, Benedikt   +4 more
core   +1 more source

Metabolic labeling with an alkyne probe reveals similarities and differences in the prenylomes of several brain-derived cell lines and primary cells

Scientific Reports, 2021
Protein prenylation involves the attachment of one or two isoprenoid group(s) onto cysteine residues positioned near the C-terminus. This modification is essential for many signal transduction processes.
Kiall F. Suazo, Angela Jeong, Mina Ahmadi, Caroline Brown, Wenhui Qu, Ling Li, Mark D. Distefano   +6 more
doaj   +1 more source

Cloning and characterisation of chlorophyll synthase from Avena sativa [PDF]

, 2001
The chlorophyll synthase gene from oat (Avena sativa) was cloned and expressed in Escherichia coli. The deduced amino acid sequence consists of 378 amino acids including a presequence, of 46 amino acids.
Kögel, Julia, Lenz, Stefan, Oster, Ulrike, Rüdiger, Wolfhart, Schmid, Heidi C.   +4 more
core   +1 more source

Functional screening reveals Toxoplasma prenylated proteins required for endocytic trafficking and rhoptry protein sorting

mBio, 2023
In the apicomplexans, endocytosed cargos (e.g., hemoglobin) are trafficked to a specialized organelle for digestion. This follows a unique endocytotic process at the micropore/cytostome in these parasites.
Qiang-Qiang Wang, Ming Sun, Tao Tang, De-Hua Lai, Jing Liu, Sanjay Maity, Kai He, Xi-Ting Wu, Jiong Yang, Yue-Bao Li, Xiao-Yan Tang, Hui-Yong Ding, Geoff Hide, Mark Distefano, Zhao-Rong Lun, Xing-Quan Zhu, Shaojun Long   +16 more
doaj   +1 more source

Biological evaluations of novel 2,3,3-Trisphosphonate in osteoclastic and osteoblastic activities [PDF]

, 2017
Bisphosphonates (BPs) are the first line treatment for many bone diseases including hypercalcimia associated with bone malignancies. In this paper, we introduce a new analogue of bisphosphonate called the 2,3,3-Trisphosphonate (2,3,3-TriPP) that was ...
Boccaccini, Aldo R., Cheong, Yuen Ki, Detsch, Rainer, Huang, Mei, Ren, Guogang   +4 more
core   +3 more sources

Phosphatase of regenerating liver-3 localizes to cyto-membrane and is required for B16F1 melanoma cell metastasis in vitro and in vivo. [PDF]

PLoS ONE, 2009
BACKGROUND: Phosphatase of regenerating liver-3 (PRL-3) is a member of the novel phosphatases of regenerating liver family, characterized by one protein tyrosine phosphatase active domain and a C-terminal prenylation (CCVM) motif.
Ran Song, Feng Qian, Yu-Pei Li, Xia Sheng, Shao-Xian Cao, Qiang Xu   +5 more
doaj   +1 more source

PTP4A1 promotes TGFβ signaling and fibrosis in systemic sclerosis. [PDF]

, 2017
Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis of skin and internal organs. Protein tyrosine phosphatases have received little attention in the study of SSc or fibrosis.
Bai, Yunpeng, Boin, Francesco, Bottini, Nunzio, Ceponis, Arnold, Chernitskiy, Vladimir, Cipriani, Paola, Di Benedetto, Paola, Giacomelli, Roberto, Jimenez, Sergio A, Kaestner, Klaus H, Kiosses, William B, Piera-Velazquez, Sonsoles, Sacchetti, Cristiano, Santelli, Eugenio, Stanford, Stephanie M, Zhang, Zhong-Yin   +15 more
core   +2 more sources

HDV can constrain HBV genetic evolution in hbsag: Implications for the identification of innovative pharmacological targets [PDF]

, 2018
Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection.
Andreoni, Massimo, Angelico, Mario, Barlattani, Angelo, Battisti, Arianna, Bertoli, Ada, Cappiello, Giuseppina, Carioti, Luca, Ceccherini-Silberstein, Francesca, Colagrossi, Luna, Coppola, Nicola, De Cristofaro, Maria, DE SANCTIS, Giuseppe Maria, Fabeni, Lavinia, Fleury, Hervé, Iapadre, Nerio, Lanza, Alfonso Galeota, Lenci, Ilaria, Lichtner, Miriam, Malagnino, Vincenzo, Mari, Terenzio, Marignani, Massimo, Mastroianni, Claudio, Minichini, Carmine, Nebuloso, Elena, Pasquazzi, Caterina, Perno, Carlo-Federico, Piermatteo, Lorenzo, Salpini, Romina, Sarmati, Loredana, Scutari, Rossana, Spanò, Alberto, Stanzione, Maria, Stornaiuolo, Gianfranca, Svicher, Valentina, Trimoulet, Pascale   +34 more
core   +2 more sources

A Comprehensive Analysis of Choroideremia: From Genetic Characterization to Clinical Practice. [PDF]

, 2016
Choroideremia (CHM) is a rare X-linked disease leading to progressive retinal degeneration resulting in blindness. The disorder is caused by mutations in the CHM gene encoding REP-1 protein, an essential component of the Rab geranylgeranyltransferase ...
Avila-Fernandez, A., Ayuso, C., Blanco-Kelly, F., Corton, M., Garcia-Hoyos, M., Garcia-Sandoval, B., Gimenez, A., Kalatzis, V., Lopez-Martinez, M.A., Lopez-Molina, M.I., Lorda, I., Perez-Carro, R., Riveiro-Alvarez, R., Rivolta, C., Rodrigues-Jacy da Silva, L., Sanchez-Alcudia, R., Sanchez-Bolivar, N., Torriano, S., Trujillo-Tiebas, M.J., Villaverde, C., Zurita, O.   +20 more
core   +7 more sources

Increased RhoA prenylation in the loechrig (loe) mutant leads to progressive neurodegeneration. [PDF]

PLoS ONE, 2012
The Drosophila mutant loechrig (loe) shows age-dependent degeneration of the nervous system and is caused by the loss of a neuronal isoform of the AMP-activated protein kinase (AMPK) γ-subunit (also known as SNF4Aγ).
Mandy Cook, Priya Mani, Jill S Wentzell, Doris Kretzschmar   +3 more
doaj   +1 more source