Results 31 to 40 of about 3,381,535 (185)
Statin treatment increases lifespan and improves cardiac health in Drosophila by decreasing specific protein prenylation. [PDF]
PLoS ONE, 2012 Statins such as simvastatin are 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors and standard therapy for the prevention and treatment of cardiovascular diseases in mammals.
Stephen R Spindler +9 more
doaj +1 more source
Characterization, sub-cellular localization and expression profiling of the isoprenylcysteine methylesterase gene family in Arabidopsis thaliana [PDF]
, 2010 Background: Isoprenylcysteine methylesterases (ICME) demethylate prenylated protein in eukaryotic cell. Until now, knowledge about their molecular information, localization and expression pattern is largely unavailable in plant species.
Wang, H.Z. +7 more
core +1 more source
Prenylated Rab Acceptor Protein Is a Receptor for Prenylated Small GTPases [PDF]
Journal of Biological Chemistry, 2001 Localization of Ras and Ras-like proteins to the correct subcellular compartment is essential for these proteins to mediate their biological effects. Many members of the Ras superfamily (Ha-Ras, N-Ras, TC21, and RhoA) are prenylated in the cytoplasm and then transit through the endomembrane system on their way to the plasma membrane.
C, Figueroa, J, Taylor, A B, Vojtek
openaire +2 more sources
Rab GTPase prenylation hierarchy and its potential role in choroideremia disease. [PDF]
PLoS ONE, 2013 Protein prenylation is a widespread post-translational modification in eukaryotes that plays a crucial role in membrane targeting and signal transduction. RabGTPases is the largest group of post-translationally C-terminally geranylgeranylated.
Monika Köhnke +8 more
doaj +1 more source
Molecular Therapy: Methods & Clinical Development, 2018 Choroideremia (CHM) is a rare, X-linked recessive retinal dystrophy caused by mutations in the CHM gene. CHM is ubiquitously expressed in human cells and encodes Rab escort protein 1 (REP1).
Maria I. Patrício +4 more
doaj +1 more source
Platelets, 2023 Statins inhibit the mevalonate pathway by impairing protein prenylation via depletion of lipid geranylgeranyl diphosphate (GGPP). Rab27b and Rap1a are small GTPase proteins involved in dense granule secretion, platelet activation, and regulation.
Mohammed M Jalal +3 more
doaj +1 more source
Multiple domain insertions and losses in the evolution of the Rab prenylation complex
BMC Evolutionary Biology, 2007 Background Rab proteins are regulators of vesicular trafficking, requiring a lipid modification for proper function, prenylation of C-terminal cysteines.
Pereira-Leal Jose B, Rasteiro Rita
doaj +1 more source
Beyond the Mevalonate Pathway: Control of Post-Prenylation Processing by Mutant p53
Frontiers in Oncology, 2020 Missense mutations in the TP53 gene are among the most frequent alterations in human cancer. Consequently, many tumors show high expression of p53 point mutants, which may acquire novel activities that contribute to develop aggressive tumors.
Carla M Borini Etichetti +3 more
doaj +1 more source
Frontiers in Neuroscience, 2019 Thirty years after the first description and modeling of G protein coupled receptors (GPCRs), information about their mode of action is still limited. One of the questions that is hard to answer is: how do the allosteric changes in the GPCR induced by, e.
Arnold De Loof, Liliane Schoofs
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Towards complete sets of farnesylated and geranylgeranylated proteins. [PDF]
PLoS Computational Biology, 2007 Three different prenyltransferases attach isoprenyl anchors to C-terminal motifs in substrate proteins. These lipid anchors serve for membrane attachment or protein-protein interactions in many pathways.
Sebastian Maurer-Stroh +5 more
doaj +1 more source