Results 61 to 70 of about 257,655 (321)
The future of protein secondary structure prediction accuracy
Folding and Design, 1997 The accuracy of secondary structure prediction for a protein from knowledge of its sequence has been significantly improved by about 7% to the 70-75% range by inclusion of information residing in sequences similar to the query sequence. The scientific literature has been inconsistent, if not negative, regarding chances for further improvement from the ...
Patrick Argos, Dmitrij Frishman
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A Simple Comparison between Specific Protein Secondary Structure Prediction Tools
Tropical Agricultural Research, 2012 A comparative evaluation of five widely used protein secondary structure prediction programs available in World Wide Web was carried out. Secondary structure data of ten proteins containing 190 secondary structure motifs were collected from Protein Data ...
TJ Koswatta +2 more
doaj +1 more source
Protein Secondary Structure Prediction
, 2008 {"references": ["Cuff, J. A. and Barton, G.J. \"Evaluation and improvement of multiple\nsequence methods for protein secondary structure prediction. Proteins,\n34, 1999, pp. 508-519.", "Cuff, J.A. and Barton G.J. \"Application of multiple sequence alignment\nprofiles to improve protein secondary structure prediction\" Proteins, 40,\n2000, pp. 502-511.",
Manpreet Singh +2 more
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A Next Step in Protein Secondary Structure Prediction [PDF]
Biophysical Journal, 2012 We report on a new methodology for protein secondary structure prediction based on: step 1) constructing a new scoring function by taking short and long distance triplet residues interactions into consideration, 2) generating reference states from protein database with high similarity, and 3) using a genetic algorithm to refine the predictions from the
Eric Jakobsson +3 more
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The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
PROTINFO: secondary and tertiary protein structure prediction [PDF]
Nucleic Acids Research, 2003 Information about the secondary and tertiary structure of a protein sequence can greatly assist biologists in the generation and testing of hypotheses, as well as design of experiments. The PROTINFO server enables users to submit a protein sequence and request a prediction of the three-dimensional (tertiary) structure based on comparative modeling ...
Ram Samudrala, Ling-Hong Hung
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FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
Coupled prediction of protein secondary and tertiary structure [PDF]
Proceedings of the National Academy of Sciences, 2003 The strong coupling between secondary and tertiary structure formation in protein folding is neglected in most structure prediction methods. In this work we investigate the extent to which nonlocal interactions in predicted tertiary structures can be used to improve secondary structure prediction.
Jens Meiler, David Baker
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Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source