Results 1 to 10 of about 910,246 (265)
Autotransporter protein secretion [PDF]
Biomolecular Concepts, 2011 Autotransporter proteins are a large family of virulence factors secreted from Gram-negative bacteria by a unique mechanism. First described in the 1980s, these proteins have a C-terminal region that folds into a β-barrel in the bacterial outer membrane.
Tame Jeremy R.H.
doaj +3 more sources
Secreted protein kinases [PDF]
Trends in Biochemical Sciences, 2013 Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate.
Vincent S. Tagliabracci +2 more
openaire +6 more sources
Regulation of Protein Secretion by … Protein Secretion? [PDF]
Cell Host & Microbe, 2008 Mycobacterium tuberculosis (Mtb) requires an alternative protein secretion system, ESX1, for virulence. Recently, Raghavan et al. (2008) reported a new regulatory circuit that may explain how ESX1 activity is controlled during infection. Mtb appears to regulate ESX1 by modulating transcription of associated genes rather than structural components of ...
Atmakuri, Krishnamohan +1 more
openaire +2 more sources
mSystems, 2021 The type VI secretion system (T6SS) belongs to the evolutionarily related group of contractile injection systems that employ a contractile outer sheath to inject a rigid spear-like inner tube into target bacterial and eukaryotic cells.
Hao-Yu Zheng, Liang Yang, Tao Dong
doaj +1 more source
Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane
Redox Biology, 2020 Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with ‘peroxiporin’ activity (AQP3, AQP8, AQP9).
Stefano Bestetti +6 more
doaj +1 more source
Protein secretion and secreted proteins in pathogenicNeisseriaceae [PDF]
FEMS Microbiology Reviews, 2006 Secreted proteins of pathogenic bacteria are often essential virulence factors. They are involved, for example, in the adherence of the bacteria to host cells or required to suppress the host's defence mechanisms. Until recently, only IgA1 protease had been studied in detail in the NeisseriaceaeNeisseria meningitidis and Neisseria gonorrhoeae.
van Ulsen, J.P., Tommassen, J.P.M.
openaire +3 more sources
Regulated Secretion: Helper proteins for neuroendocrine secretion [PDF]
Current Biology, 1995 The granins, known to be general constituents of neuroendocrine secretory granules, are regulators of the proteolytic processing of peptide precursors and promote their aggregation-mediated sorting into secretory granules.
Huttner, Wieland B., Natori, Shoichi
openaire +2 more sources
EMBO Molecular Medicine, 2020 Cancer‐associated fibroblasts (CAFs) are considered the most abundant type of stromal cells in pancreatic ductal adenocarcinoma (PDAC), playing a critical role in tumour progression and chemoresistance; however, a druggable target on CAFs has not yet ...
Sonia Zaghdoudi +20 more
doaj +1 more source
Biomedicines, 2022 The NF-κB system is a key transcriptional pathway that regulates innate and adaptive immunity because it triggers the activation and differentiation processes of lymphocytes and myeloid cells during immune responses.
Jasmin Priester +3 more
doaj +1 more source
Structures of the Type IX Secretion/Gliding Motility Motor from across the Phylum Bacteroidetes
mBio, 2022 Gliding motility using cell surface adhesins, and export of proteins by the type IX secretion system (T9SS) are two phylum-specific features of the Bacteroidetes.
Rory Hennell James +4 more
doaj +1 more source