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Autotransporter protein secretion [PDF]
Biomolecular Concepts, 2011 Autotransporter proteins are a large family of virulence factors secreted from Gram-negative bacteria by a unique mechanism. First described in the 1980s, these proteins have a C-terminal region that folds into a β-barrel in the bacterial outer membrane.
Tame Jeremy R.H.
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Diverse C-Terminal Sequences Involved in Flavobacterium johnsoniae Protein Secretion [PDF]
Journal of Bacteriology, 2017 Surashree S. Kulkarni +3 more
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B. subtilis Sec and Srp Systems Show Dynamic Adaptations to Different Conditions of Protein Secretion [PDF]
CellsSecA is a widely conserved ATPase that drives the secretion of proteins across the cell membrane via the SecYEG translocon, while the SRP system is a key player in the insertion of membrane proteins via SecYEG. How SecA gains access to substrate proteins
Svenja M. Fiedler, Peter L. Graumann
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Secreted protein kinases [PDF]
Trends in Biochemical Sciences, 2013 Protein kinases constitute one of the largest gene families and control many aspects of cellular life. In retrospect, the first indication for their existence was reported 130 years ago when the secreted protein, casein, was shown to contain phosphate.
Vincent S. Tagliabracci +2 more
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Unconventional Pathways of Protein Secretion: Mammals vs. Plants
Frontiers in Cell and Developmental Biology, 2022 In eukaryotes, many proteins contain an N-terminal signal peptide that allows their translocation into the endoplasmic reticulum followed by secretion outside the cell according to the classical secretory system. However, an increasing number of secreted
Elisa Maricchiolo +5 more
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Nature Communications, 2021 Secreted proteins, such as hormones or cytokines, are key mediators in multicellular organisms. Response of protein secretion based on transcriptional control is rather slow, as it requires transcription, translation and transport from the endoplasmic ...
Arne Praznik +8 more
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Regulation of Protein Secretion by … Protein Secretion? [PDF]
Cell Host & Microbe, 2008 Mycobacterium tuberculosis (Mtb) requires an alternative protein secretion system, ESX1, for virulence. Recently, Raghavan et al. (2008) reported a new regulatory circuit that may explain how ESX1 activity is controlled during infection. Mtb appears to regulate ESX1 by modulating transcription of associated genes rather than structural components of ...
Atmakuri, Krishnamohan +1 more
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mSystems, 2021 The type VI secretion system (T6SS) belongs to the evolutionarily related group of contractile injection systems that employ a contractile outer sheath to inject a rigid spear-like inner tube into target bacterial and eukaryotic cells.
Hao-Yu Zheng, Liang Yang, Tao Dong
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Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane
Redox Biology, 2020 Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with ‘peroxiporin’ activity (AQP3, AQP8, AQP9).
Stefano Bestetti +6 more
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