Results 211 to 220 of about 1,399,144 (265)
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Protein Targeting in the Neuron
Annual Review of Neuroscience, 1993The morphology of the neuron is essential to its function. Each mor phological specialization of the neuron, the dendrite, the dendritic spines, the axon, the axon hillock, the nodes of Ranvier, the active zone, and the synaptic vesicle appears to have a unique protein composition.
R B, Kelly, E, Grote
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Protein targeting to peroxisomes
Biochemical Society Transactions, 1990Peroxisomes are single-membrane-bound organelles that have important functions in cell metabolism. They are almost ubiquitous in eukaryotic cells and biochemical findings over the past 10 years have shown that they are involved in cell respiration, and also play a significant role in lipid metabolism (for reviews, see [ l , 21).
G M, Small, A S, Lewin
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Targeting of lysosomal proteins
Seminars in Cell & Developmental Biology, 2000Proper cell homeostasis requires the efficient transport of a large variety of soluble acid hydrolases and transmembrane proteins from the trans-Golgi network (TGN) to lysosomes. While most of these molecules reach this degradative compartment, some transmembrane proteins, in particular, the acid hydrolase receptors are retrieved to the TGN.
Y, Rouillé, W, Rohn, B, Hoflack
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Science, 1996
Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules.
R B, Vallee, M P, Sheetz
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Microtubules are responsible for chromosome segregation and the movement and reorganization of membranous organelles. Many aspects of microtubule-based motility can be attributed to the action of motor proteins, producing force directed toward either end of microtubules.
R B, Vallee, M P, Sheetz
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Targeting of proteins into chloroplasts
BioEssays, 1988AbstractCytoplasmically synthesized proteins are directed into chloroplasts by amino terminal transit sequences of the precursor proteins. For proteins of the thylakoid lumen, transit sequences are also important in directing proteins to the lumen.
K, Keegstra, C, Bauerle
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Protein targeting and protein secretion
Genome, 1989The two scheduled workshops entitled Protein Secretion and Protein Targeting were combined into a single session on Monday, August 22, before a large audience. We record here the highlights of these talks, which supplement the information already available in the published abstracts.
M E, Dumont, F, Sherman, D Y, Thomas
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Proteolysis-targeting Chimeras for Targeting Protein for Degradation
Future Medicinal Chemistry, 2019Proteolysis-targeting chimeras (PROTACs) are an emerging tool for therapeutic intervention by reducing or eliminating disease-causing proteins. PROTACs are bifunctional molecules that consist of a target protein ligand, a linker and an E3 ligase ligand, which mediate the polyubiquitination of the target protein, ultimately leading to the target protein
Jianguo, Qi, Gang, Zhang
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Current Opinion in Chemical Biology, 2005
The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
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The ubiquitin-proteasome pathway plays a major role in cellular protein destruction and regulates fundamental cellular processes such as the cell cycle, cell signaling, and development. By altering the substrate recognition of ubiquitin-protein ligases, their robust proteolytic activity can be re-directed to recruit and accelerate the degradation of ...
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Protein–Protein Interactions as Drug Targets
Future Medicinal Chemistry, 2015Modulation of protein-protein interactions (PPIs) is becoming increasingly important in drug discovery and chemical biology. While a few years ago this 'target class' was deemed to be largely undruggable an impressing number of publications and success stories now show that targeting PPIs with small, drug-like molecules indeed is a feasible approach ...
Skwarczynska, Malgorzata +1 more
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On‐target ultrasonic digestion of proteins
PROTEOMICS, 2013In the present work, we report a novel on‐target protein cleavage method. The method utilizes ultrasonic energy and allows up to 20 samples to be cleaved in 5 min for protein identification and one sample in 30 s for on‐tissue digestion. The standard proteins were spotted on a conductive glass slide in a volume of 0.5 μL followed by 5 min of ...
Santos, Hugo M. +3 more
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